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Page 1
Epidermal growth factor receptor-dependent DNA repair promotes murine and human hematopoietic regeneration.
Fang T, Zhang Y, Chang VY, Roos M, Termini CM, Signaevskaia L, Quarmyne M, Lin PK, Pang A, Kan J, Yan X, Javier A, Pohl K, Zhao L, Scott P, Himburg HA, Chute JP. Fang T, et al. Blood. 2020 Jul 23;136(4):441-454. doi: 10.1182/blood.2020005895. Blood. 2020. PMID: 32369572 Free PMC article.
EGF has therapeutic potential to promote human hematopoietic regeneration, and further studies are warranted to assess long-term hematopoietic effects....
EGF has therapeutic potential to promote human hematopoietic regeneration, and further studies are warranted to assess long-term hema …
The Aftermath of Surviving Acute Radiation Hematopoietic Syndrome and its Mitigation.
Micewicz ED, Iwamoto KS, Ratikan JA, Nguyen C, Xie MW, Cheng G, Boxx GM, Deriu E, Damoiseaux RD, Whitelegge JP, Ruchala PP, Avetisyan R, Jung ME, Lawson G, Nemeth E, Ganz T, Sayre JW, McBride WH, Schaue D. Micewicz ED, et al. Radiat Res. 2019 Apr;191(4):323-334. doi: 10.1667/RR15231.1. Epub 2019 Feb 7. Radiat Res. 2019. PMID: 30730284 Free PMC article.
Histopathological changes are largely of a chronic inflammatory nature and variable incidence, as are the clinical symptoms, including late diarrhea that correlates temporally with changes in the content of the microbiome. We also describe the acute and long-term consequen …
Histopathological changes are largely of a chronic inflammatory nature and variable incidence, as are the clinical symptoms, including late …
Direct quantification of gamma H2AX by cell-based high throughput screening for evaluation of genotoxicity of pesticides in a human thyroid cell lines.
Hershman JM, France B, Hon K, Damoiseaux R. Hershman JM, et al. Environ Mol Mutagen. 2017 Aug;58(7):522-528. doi: 10.1002/em.22103. Epub 2017 Jun 22. Environ Mol Mutagen. 2017. PMID: 28640454 Free PMC article.
We found that 19 pesticides induce DSB in vitro, highlighting a need to further assess these pesticides for their long-term oncogenic effects on the thyroid gland. Environ. Mol. Mutagen. 58:522-528, 2017. 2017 Wiley Periodicals, Inc....
We found that 19 pesticides induce DSB in vitro, highlighting a need to further assess these pesticides for their long-term oncogenic …
Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms.
Himburg HA, Doan PL, Quarmyne M, Yan X, Sasine J, Zhao L, Hancock GV, Kan J, Pohl KA, Tran E, Chao NJ, Harris JR, Chute JP. Himburg HA, et al. Nat Med. 2017 Jan;23(1):91-99. doi: 10.1038/nm.4251. Epub 2016 Dec 5. Nat Med. 2017. PMID: 27918563 Free PMC article.
Treatment of irradiated HSCs with Dkk1 in vitro increased the recovery of both long-term repopulating HSCs and progenitor cells, and systemic administration of Dkk1 to irradiated mice increased hematopoietic recovery and improved survival. ...
Treatment of irradiated HSCs with Dkk1 in vitro increased the recovery of both long-term repopulating HSCs and progenitor cells, and …
Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration.
Yan X, Himburg HA, Pohl K, Quarmyne M, Tran E, Zhang Y, Fang T, Kan J, Chao NJ, Zhao L, Doan PL, Chute JP. Yan X, et al. Cell Rep. 2016 Nov 1;17(6):1584-1594. doi: 10.1016/j.celrep.2016.10.025. Cell Rep. 2016. PMID: 27806297 Free PMC article.
Deletion of the maternal allele of Grb10 in mice (Grb10(m/+) mice) substantially increased HSC long-term repopulating capacity, as compared to that of Grb10(+/+) mice. ...
Deletion of the maternal allele of Grb10 in mice (Grb10(m/+) mice) substantially increased HSC long-term repopulating capacity, as co …
Changes in Imaging and Cognition in Juvenile Rats After Whole-Brain Irradiation.
Brown RJ, Jun BJ, Cushman JD, Nguyen C, Beighley AH, Blanchard J, Iwamoto K, Schaue D, Harris NG, Jentsch JD, Bluml S, McBride WH. Brown RJ, et al. Int J Radiat Oncol Biol Phys. 2016 Oct 1;96(2):470-478. doi: 10.1016/j.ijrobp.2016.06.013. Epub 2016 Jun 16. Int J Radiat Oncol Biol Phys. 2016. PMID: 27478168 Free PMC article.
PURPOSE: In pediatric cancer survivors treated with whole-brain irradiation (WBI), long-term cognitive deficits and morbidity develop that are poorly understood and for which there is no treatment. ...
PURPOSE: In pediatric cancer survivors treated with whole-brain irradiation (WBI), long-term cognitive deficits and morbidity develop …
A Molecular Profile of the Endothelial Cell Response to Ionizing Radiation.
Himburg HA, Sasine J, Yan X, Kan J, Dressman H, Chute JP. Himburg HA, et al. Radiat Res. 2016 Aug;186(2):141-52. doi: 10.1667/RR14444.1. Epub 2016 Jul 7. Radiat Res. 2016. PMID: 27387861 Free PMC article.
Radiation damages quiescent hematopoietic stem cells (HSCs) and proliferating hematopoietic cells, resulting in neutropenia, thrombocytopenia and increased risk for long-term hematopoietic dysfunction and myelodysplasia. While some aspects of the hematopoietic response to …
Radiation damages quiescent hematopoietic stem cells (HSCs) and proliferating hematopoietic cells, resulting in neutropenia, thrombocytopeni …
Genetic modification of mouse bone marrow by lentiviral vector-mediated delivery of hypoxanthine-Guanine phosphoribosyltransferase short hairpin RNA confers chemoprotection against 6-thioguanine cytotoxicity.
Hacke K, Treger JA, Bogan BT, Schiestl RH, Kasahara N. Hacke K, et al. Transplant Proc. 2013 Jun;45(5):2040-4. doi: 10.1016/j.transproceed.2013.01.020. Transplant Proc. 2013. PMID: 23769104 Free PMC article.
In a mouse BM transplantation model, combined 6TG preconditioning and in vivo chemoselection consistently achieved >95% engraftment of HPRT-deficient donor BM and long-term reconstitution of histologically and immunophenotypically normal hematopoiesis in both primary an …
In a mouse BM transplantation model, combined 6TG preconditioning and in vivo chemoselection consistently achieved >95% engraftment of HP …
Combined preconditioning and in vivo chemoselection with 6-thioguanine alone achieves highly efficient reconstitution of normal hematopoiesis with HPRT-deficient bone marrow.
Hacke K, Szakmary A, Cuddihy AR, Rozengurt N, Lemp NA, Aubrecht J, Lawson GW, Rao NP, Crooks GM, Schiestl RH, Kasahara N. Hacke K, et al. Exp Hematol. 2012 Jan;40(1):3-13.e3. doi: 10.1016/j.exphem.2011.09.009. Epub 2011 Oct 12. Exp Hematol. 2012. PMID: 22001673 Free PMC article.
Combined 6TG conditioning and post-transplantation chemoselection consistently achieved 95% engraftment of HPRT-deficient donor BM, with low overall toxicity. Long-term reconstitution of immunophenotypically normal BM was achieved in both primary and secondary recipients. …
Combined 6TG conditioning and post-transplantation chemoselection consistently achieved 95% engraftment of HPRT-deficient donor BM, with low …
Suppression of HLA expression by lentivirus-mediated gene transfer of siRNA cassettes and in vivo chemoselection to enhance hematopoietic stem cell transplantation.
Hacke K, Falahati R, Flebbe-Rehwaldt L, Kasahara N, Gaensler KM. Hacke K, et al. Immunol Res. 2009;44(1-3):112-26. doi: 10.1007/s12026-008-8088-z. Immunol Res. 2009. PMID: 19048410 Free PMC article.
We have been exploring two complementary approaches for genetically modifying donor cells that achieve long-term suppression of cellular proteins that elicit host immune responses to mismatched donor antigens, and provide a selective advantage to genetically engineered don …
We have been exploring two complementary approaches for genetically modifying donor cells that achieve long-term suppression of cellu …