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Association of Trauma Molecular Endotypes With Differential Response to Transfusion Resuscitation Strategies.
Thau MR, Liu T, Sathe NA, O'Keefe GE, Robinson BRH, Bulger E, Wade CE, Fox EE, Holcomb JB, Liles WC, Stanaway IB, Mikacenic C, Wurfel MM, Bhatraju PK, Morrell ED. Thau MR, et al. JAMA Surg. 2023 Jul 1;158(7):728-736. doi: 10.1001/jamasurg.2023.0819. JAMA Surg. 2023. PMID: 37099286 Free PMC article.
Differential treatment response to transfusion strategy was assessed using an RR regression model for 30-day mortality by incorporating an interaction term for the product of endotype and treatment group adjusting for age, sex, trauma center, mechanism of injury, and ISS. …
Differential treatment response to transfusion strategy was assessed using an RR regression model for 30-day mortality by incorporating an i …
CPR compression strategy 30:2 is difficult to adhere to, but has better survival than continuous chest compressions when done correctly.
Schmicker RH, Nichol G, Kudenchuk P, Christenson J, Vaillancourt C, Wang HE, Aufderheide TP, Idris AH, Daya MR. Schmicker RH, et al. Resuscitation. 2021 Aug;165:31-37. doi: 10.1016/j.resuscitation.2021.05.027. Epub 2021 Jun 5. Resuscitation. 2021. PMID: 34098033 Free PMC article.
Effect modification with intended strategy was assessed through a multiplicative interaction term. RESULTS: Included were 26,810 adults with out of hospital cardiac arrest, of which 10,942 had an intended strategy of 30:2 and 15,868 an intended strategy of CCC. ...
Effect modification with intended strategy was assessed through a multiplicative interaction term. RESULTS: Included were 26,810 adul …
Severely injured trauma patients with admission hyperfibrinolysis: Is there a role of tranexamic acid? Findings from the PROPPR trial.
Khan M, Jehan F, Bulger EM, OʼKeeffe T, Holcomb JB, Wade CE, Schreiber MA, Joseph B; PROPPR Study Group. Khan M, et al. J Trauma Acute Care Surg. 2018 Nov;85(5):851-857. doi: 10.1097/TA.0000000000002022. J Trauma Acute Care Surg. 2018. PMID: 29985230 Free PMC article.
CONCLUSION: Tranexamic acid was associated with increased 6-hour survival but does not improve long-term outcomes in severely injured trauma patients with hemorrhage who develop hyperfibrinolysis. ...
CONCLUSION: Tranexamic acid was associated with increased 6-hour survival but does not improve long-term outcomes in severely injured …
Long-term clinical outcomes and predictors for survivors of out-of-hospital cardiac arrest.
Shuvy M, Morrison LJ, Koh M, Qiu F, Buick JE, Dorian P, Scales DC, Tu JV, Verbeek PR, Wijeysundera HC, Ko DT; Rescu Epistry Investigators. Shuvy M, et al. Resuscitation. 2017 Mar;112:59-64. doi: 10.1016/j.resuscitation.2016.12.026. Epub 2017 Jan 16. Resuscitation. 2017. PMID: 28104428
AIMS: Improvement in resuscitation efforts has translated to an increasing number of survivors after out-of-hospital cardiac arrest (OHCA). Our objectives were to assess the long-term outcomes and predictors of mortality for patients who survived OHCA. ...Prior cardiac con …
AIMS: Improvement in resuscitation efforts has translated to an increasing number of survivors after out-of-hospital cardiac arrest (OHCA). …
Early prediction of outcome after severe traumatic brain injury: a simple and practical model.
Rizoli S, Petersen A, Bulger E, Coimbra R, Kerby JD, Minei J, Morrison L, Nathens A, Schreiber M, de Oliveira Manoel AL; ROC Investigators. Rizoli S, et al. BMC Emerg Med. 2016 Aug 24;16(1):32. doi: 10.1186/s12873-016-0098-x. BMC Emerg Med. 2016. PMID: 27553436 Free PMC article. Clinical Trial.
BACKGROUND: Traumatic brain injury (TBI) is a heterogeneous syndrome with a broad range of outcome. We developed a simple model for long-term outcome prognostication after severe TBI. METHODS: Secondary data analysis of a large multicenter randomized trial. ...Our model wa …
BACKGROUND: Traumatic brain injury (TBI) is a heterogeneous syndrome with a broad range of outcome. We developed a simple model for long- …