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Year Number of Results
2006 1
2008 1
2009 1
2010 2
2011 1
2013 2
2014 5
2016 1
2017 4
2018 4
2019 3
2020 7
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2022 3
2023 1
2024 2

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39 results

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Page 1
Relationships of change in Clinical Dementia Rating (CDR) on patient outcomes and probability of progression: observational analysis.
Tariot PN, Boada M, Lanctôt KL, Hahn-Pedersen J, Dabbous F, Udayachalerm S, Raket LL, Halchenko Y, Michalak W, Weidner W, Cummings J. Tariot PN, et al. Alzheimers Res Ther. 2024 Feb 15;16(1):36. doi: 10.1186/s13195-024-01399-7. Alzheimers Res Ther. 2024. PMID: 38355706 Free PMC article.
BACKGROUND: Understanding the relationship among changes in Clinical Dementia Rating (CDR), patient outcomes, and probability of progression is crucial for evaluating the long-term benefits of disease-modifying treatments. We examined associations among changes in Alzheime …
BACKGROUND: Understanding the relationship among changes in Clinical Dementia Rating (CDR), patient outcomes, and probability of progression …
Anatomical MRI staging of frontotemporal dementia variants.
Planche V, Mansencal B, Manjon JV, Tourdias T, Catheline G, Coupé P; Frontotemporal Lobar Degeneration Neuroimaging Initiative and the National Alzheimer's Coordinating Center cohort. Planche V, et al. Alzheimers Dement. 2023 Aug;19(8):3283-3294. doi: 10.1002/alz.12975. Epub 2023 Feb 7. Alzheimers Dement. 2023. PMID: 36749884
INTRODUCTION: The three clinical variants of frontotemporal dementia (behavioral variant [bvFTD], semantic dementia, and progressive non-fluent aphasia [PNFA]) are likely to develop over decades, from the preclinical stage to death. METHODS: To describe the long-term chron …
INTRODUCTION: The three clinical variants of frontotemporal dementia (behavioral variant [bvFTD], semantic dementia, and progressive non-flu …
Global cognitive trajectory patterns in Alzheimer's disease.
Cohen CI, Reisberg B, Yaffee R. Cohen CI, et al. Int Psychogeriatr. 2024 Mar;36(3):200-209. doi: 10.1017/S1041610222000047. Epub 2022 Mar 25. Int Psychogeriatr. 2024. PMID: 35331359
OBJECTIVES: The literature on Alzheimer's disease (AD) provides little data about long-term cognitive course trajectories. We identify global cognitive outcome trajectories and associated predictor variables that may inform clinical research and care. ...
OBJECTIVES: The literature on Alzheimer's disease (AD) provides little data about long-term cognitive course trajectories. We identif …
c-Abl-induced Olig2 phosphorylation regulates the proliferation of oligodendrocyte precursor cells.
Zhang J, Sun JG, Xing X, Wu R, Zhou L, Zhang Y, Yuan F, Wang S, Yuan Z. Zhang J, et al. Glia. 2022 Jun;70(6):1084-1099. doi: 10.1002/glia.24157. Epub 2022 Feb 13. Glia. 2022. PMID: 35156232
In addition, we found that nilotinib, a clinically used c-Abl inhibitor, decreased the expression of myelin basic protein (Mbp) and motor coordination in mice, indicating a neurological side effect of a long-term administration of the c-Abl inhibitor. Thus, we identified t …
In addition, we found that nilotinib, a clinically used c-Abl inhibitor, decreased the expression of myelin basic protein (Mbp) and motor co …
Reassessing Diabetes and APOE Genotype as Potential Interacting Risk Factors for Alzheimer's Disease.
Ravipati K, Chen Y, Manns JR. Ravipati K, et al. Am J Alzheimers Dis Other Demen. 2022 Jan-Dec;37:15333175211070912. doi: 10.1177/15333175211070912. Am J Alzheimers Dis Other Demen. 2022. PMID: 35041557 Free PMC article.
Diabetes did not exacerbate the odds of AD in APOE epsilon4 carriers. APOE epsilon4 carriage was correlated with declines in long-term memory and verbal fluency, which were strongly correlated with conversion to AD. ...
Diabetes did not exacerbate the odds of AD in APOE epsilon4 carriers. APOE epsilon4 carriage was correlated with declines in long-term …
Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration.
Rojas JC, Wang P, Staffaroni AM, Heller C, Cobigo Y, Wolf A, Goh SM, Ljubenkov PA, Heuer HW, Fong JC, Taylor JB, Veras E, Song L, Jeromin A, Hanlon D, Yu L, Khinikar A, Sivasankaran R, Kieloch A, Valentin MA, Karydas AM, Mitic LL, Pearlman R, Kornak J, Kramer JH, Miller BL, Kantarci K, Knopman DS, Graff-Radford N, Petrucelli L, Rademakers R, Irwin DJ, Grossman M, Ramos EM, Coppola G, Mendez MF, Bordelon Y, Dickerson BC, Ghoshal N, Huey ED, Mackenzie IR, Appleby BS, Domoto-Reilly K, Hsiung GR, Toga AW, Weintraub S, Kaufer DI, Kerwin D, Litvan I, Onyike CU, Pantelyat A, Roberson ED, Tartaglia MC, Foroud T, Chen W, Czerkowicz J, Graham DL, van Swieten JC, Borroni B, Sanchez-Valle R, Moreno F, Laforce R, Graff C, Synofzik M, Galimberti D, Rowe JB, Masellis M, Finger E, Vandenberghe R, de Mendonça A, Tagliavini F, Santana I, Ducharme S, Butler CR, Gerhard A, Levin J, Danek A, Otto M, Sorbi S, Cash DM, Convery RS, Bocchetta M, Foiani M, Greaves CV, Peakman G, Russell L, Swift I, Todd E, Rohrer JD, Boeve BF, Rosen HJ, Boxer AL; ALLFTD and GENFI consortia. Rojas JC, et al. Neurology. 2021 May 4;96(18):e2296-e2312. doi: 10.1212/WNL.0000000000011848. Epub 2021 Apr 7. Neurology. 2021. PMID: 33827960 Free PMC article. Clinical Trial.
CONCLUSIONS: Plasma NfL identifies asymptomatic carriers of FTLD-causing mutations at short-term risk of disease progression and is a potential tool to select participants for prevention clinical trials. ...CLASSIFICATION OF EVIDENCE: This study provides Class I evidence t …
CONCLUSIONS: Plasma NfL identifies asymptomatic carriers of FTLD-causing mutations at short-term risk of disease progression and is a …
Five-Year Change in Body Mass Index Predicts Conversion to Mild Cognitive Impairment or Dementia Only in APOE ɛ4 Allele Carriers.
Kadey KR, Woodard JL, Moll AC, Nielson KA, Smith JC, Durgerian S, Rao SM. Kadey KR, et al. J Alzheimers Dis. 2021;81(1):189-199. doi: 10.3233/JAD-201360. J Alzheimers Dis. 2021. PMID: 33749649 Free PMC article.
Interventions and behaviors aimed at maintaining body mass may be important for long term cognitive health in older adults at genetic risk for AD....
Interventions and behaviors aimed at maintaining body mass may be important for long term cognitive health in older adults at genetic …
Cerebrovascular and Neurodegenerative Pathologies in Long-Term Stable Mild Cognitive Impairment.
Sharma MJ, Callahan BL. Sharma MJ, et al. J Alzheimers Dis. 2021;79(3):1269-1283. doi: 10.3233/JAD-200829. J Alzheimers Dis. 2021. PMID: 33427736
OBJECTIVE: To quantify the presence of neurodegenerative and vascular pathologies in individuals with long-term (>5-year) sMCI, in a preliminary test of the hypothesis that CVD may be a contributor to non-degenerative cognitive impairment. ...CONCLUSION: The most freque …
OBJECTIVE: To quantify the presence of neurodegenerative and vascular pathologies in individuals with long-term (>5-year) sMCI, in …
Robust parametric modeling of Alzheimer's disease progression.
Mehdipour Ghazi M, Nielsen M, Pai A, Modat M, Jorge Cardoso M, Ourselin S, Sørensen L. Mehdipour Ghazi M, et al. Neuroimage. 2021 Jan 15;225:117460. doi: 10.1016/j.neuroimage.2020.117460. Epub 2020 Oct 16. Neuroimage. 2021. PMID: 33075562 Free PMC article.
Quantitative characterization of disease progression using longitudinal data can provide long-term predictions for the pathological stages of individuals. This work studies the robust modeling of Alzheimer's disease progression using parametric methods. ...
Quantitative characterization of disease progression using longitudinal data can provide long-term predictions for the pathological s …
39 results