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Dynamic genome-wide gene expression and immune cell composition in the developing human placenta.
Suryawanshi H, Max K, Bogardus KA, Sopeyin A, Chang MS, Morozov P, Castano PM, Tuschl T, Williams Z. Suryawanshi H, et al. Among authors: tuschl t. J Reprod Immunol. 2022 Jun;151:103624. doi: 10.1016/j.jri.2022.103624. Epub 2022 Apr 16. J Reprod Immunol. 2022. PMID: 35490534
To generate a reference gene expression map of first (T1), second (T2) and third (T3) trimester human placenta, and assess differences in transcriptome in maternal versus fetal side tissues sections of full-term placenta, we performed RNA-Seq analysis on 64 biopsy samples …
To generate a reference gene expression map of first (T1), second (T2) and third (T3) trimester human placenta, and assess differences in tr …
Human plasma and serum extracellular small RNA reference profiles and their clinical utility.
Max KEA, Bertram K, Akat KM, Bogardus KA, Li J, Morozov P, Ben-Dov IZ, Li X, Weiss ZR, Azizian A, Sopeyin A, Diacovo TG, Adamidi C, Williams Z, Tuschl T. Max KEA, et al. Among authors: tuschl t. Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5334-E5343. doi: 10.1073/pnas.1714397115. Epub 2018 May 18. Proc Natl Acad Sci U S A. 2018. PMID: 29777089 Free PMC article.
Collectively, these results demonstrate an efficient and quantitative method to discern exRNA phenotypes and suggest that plasma and serum RNA profiles are stable over months and can be routinely monitored in long-term clinical studies....
Collectively, these results demonstrate an efficient and quantitative method to discern exRNA phenotypes and suggest that plasma and serum R …
Reprogramming of the microRNA transcriptome mediates resistance to rapamycin.
Totary-Jain H, Sanoudou D, Ben-Dov IZ, Dautriche CN, Guarnieri P, Marx SO, Tuschl T, Marks AR. Totary-Jain H, et al. Among authors: tuschl t. J Biol Chem. 2013 Mar 1;288(9):6034-44. doi: 10.1074/jbc.M112.416446. Epub 2013 Jan 8. J Biol Chem. 2013. PMID: 23300087 Free PMC article.
Given the emerging role of microRNAs (miRNAs) in tumorigenesis, we hypothesized that miRNAs could play important roles in the response of tumors to mTOR inhibitors. Long-term rapamycin treatment showed extensive reprogramming of miRNA expression, characterized by up-regula …
Given the emerging role of microRNAs (miRNAs) in tumorigenesis, we hypothesized that miRNAs could play important roles in the response of tu …
A role for neuronal piRNAs in the epigenetic control of memory-related synaptic plasticity.
Rajasethupathy P, Antonov I, Sheridan R, Frey S, Sander C, Tuschl T, Kandel ER. Rajasethupathy P, et al. Among authors: tuschl t. Cell. 2012 Apr 27;149(3):693-707. doi: 10.1016/j.cell.2012.02.057. Cell. 2012. PMID: 22541438 Free PMC article.
We find that the Piwi/piRNA complex facilitates serotonin-dependent methylation of a conserved CpG island in the promoter of CREB2, the major inhibitory constraint of memory in Aplysia, leading to enhanced long-term synaptic facilitation. These findings provide a small RNA …
We find that the Piwi/piRNA complex facilitates serotonin-dependent methylation of a conserved CpG island in the promoter of CREB2, the majo …
PAR-CliP--a method to identify transcriptome-wide the binding sites of RNA binding proteins.
Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, Rothballer A, Ascano M, Jungkamp AC, Munschauer M, Ulrich A, Wardle GS, Dewell S, Zavolan M, Tuschl T. Hafner M, et al. Among authors: tuschl t. J Vis Exp. 2010 Jul 2;(41):2034. doi: 10.3791/2034. J Vis Exp. 2010. PMID: 20644507 Free PMC article.
We developed a powerful cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs that we term PAR-CliP (Photoactivatable-Ribonucleoside-Enhanced Crosslinking and Immunoprecipitation) (see Fig. 1A …
We developed a powerful cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellula …
Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo.
Wibrand K, Panja D, Tiron A, Ofte ML, Skaftnesmo KO, Lee CS, Pena JT, Tuschl T, Bramham CR. Wibrand K, et al. Among authors: tuschl t. Eur J Neurosci. 2010 Feb;31(4):636-45. doi: 10.1111/j.1460-9568.2010.07112.x. Eur J Neurosci. 2010. PMID: 20384810 Free PMC article.
Regulation of microRNA (miRNA) expression and function in the context of activity-dependent synaptic plasticity in the adult brain is little understood. Here, we examined miRNA expression during long-term potentiation (LTP) in the dentate gyrus of adult anesthetized rats. …
Regulation of microRNA (miRNA) expression and function in the context of activity-dependent synaptic plasticity in the adult brain is little …
Characterization of small RNAs in Aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB.
Rajasethupathy P, Fiumara F, Sheridan R, Betel D, Puthanveettil SV, Russo JJ, Sander C, Tuschl T, Kandel E. Rajasethupathy P, et al. Among authors: tuschl t. Neuron. 2009 Sep 24;63(6):803-17. doi: 10.1016/j.neuron.2009.05.029. Neuron. 2009. PMID: 19778509 Free PMC article.
We therefore present direct evidence that a modulatory neurotransmitter important for learning can regulate the levels of small RNAs and present a role for miR-124 in long-term plasticity of synapses in the mature nervous system....
We therefore present direct evidence that a modulatory neurotransmitter important for learning can regulate the levels of small RNAs and pre …