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High-Titer Neutralizing Antibodies against the SARS-CoV-2 Delta Variant Induced by Alhydroxyquim-II-Adjuvanted Trimeric Spike Antigens.
Counoupas C, Pino P, Stella AO, Ashley C, Lukeman H, Bhattacharyya ND, Tada T, Anchisi S, Metayer C, Martinis J, Aggarwal A, Dcosta BM, Britton WJ, Kint J, Wurm MJ, Landau NR, Steain M, Turville SG, Wurm FM, David SA, Triccas JA. Counoupas C, et al. Among authors: turville sg. Microbiol Spectr. 2022 Feb 23;10(1):e0169521. doi: 10.1128/spectrum.01695-21. Epub 2022 Feb 16. Microbiol Spectr. 2022. PMID: 35171046 Free PMC article.
Global control of COVID-19 will require the deployment of vaccines capable of inducing long-term protective immunity against SARS-CoV-2 variants. In this report, we describe an adjuvanted subunit candidate vaccine that affords elevated, sustained, and cross-variant SARS-Co …
Global control of COVID-19 will require the deployment of vaccines capable of inducing long-term protective immunity against SARS-CoV …
The HIV-1 proviral landscape reveals that Nef contributes to HIV-1 persistence in effector memory CD4+ T cells.
Duette G, Hiener B, Morgan H, Mazur FG, Mathivanan V, Horsburgh BA, Fisher K, Tong O, Lee E, Ahn H, Shaik A, Fromentin R, Hoh R, Bacchus-Souffan C, Nasr N, Cunningham AL, Hunt PW, Chomont N, Turville SG, Deeks SG, Kelleher AD, Schlub TE, Palmer S. Duette G, et al. Among authors: turville sg. J Clin Invest. 2022 Apr 1;132(7):e154422. doi: 10.1172/JCI154422. J Clin Invest. 2022. PMID: 35133986 Free PMC article.
Despite long-term antiretroviral therapy (ART), HIV-1 persists within a reservoir of CD4+ T cells that contribute to viral rebound if treatment is interrupted. ...
Despite long-term antiretroviral therapy (ART), HIV-1 persists within a reservoir of CD4+ T cells that contribute to viral rebound if …
Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells.
Turville SG, Santos JJ, Frank I, Cameron PU, Wilkinson J, Miranda-Saksena M, Dable J, Stössel H, Romani N, Piatak M Jr, Lifson JD, Pope M, Cunningham AL. Turville SG, et al. Blood. 2004 Mar 15;103(6):2170-9. doi: 10.1182/blood-2003-09-3129. Epub 2003 Nov 20. Blood. 2004. PMID: 14630806 Free article.
Although viral harboring and transfer from nonlysosomal compartments was transient, given DC-associated virus protein, nucleic acids, and infectious HIV-1 transfer to CD4+, lymphocytes decayed within 24 hours. However a second long-term transfer phase was apparent in immat …
Although viral harboring and transfer from nonlysosomal compartments was transient, given DC-associated virus protein, nucleic acids, and in …