Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

10 results

Filters applied: . Clear all
Page 1
Acetylation-induced proteasomal degradation of the activated glucocorticoid receptor limits hormonal signaling.
Iyer-Bierhoff A, Wieczorek M, Peter SM, Ward D, Bens M, Vettorazzi S, Guehrs KH, Tuckermann JP, Heinzel T. Iyer-Bierhoff A, et al. Among authors: tuckermann jp. iScience. 2024 Jan 18;27(2):108943. doi: 10.1016/j.isci.2024.108943. eCollection 2024 Feb 16. iScience. 2024. PMID: 38333702 Free PMC article.
Notably, agonist-binding to both wild-type GR and an acetylation-deficient mutant elicits similar short-term target gene expression. In contrast, upon extended treatment, the polyubiquitination of the acetylation-deficient GR mutant is impaired resulting in higher protein …
Notably, agonist-binding to both wild-type GR and an acetylation-deficient mutant elicits similar short-term target gene expression. …
A physiological glucocorticoid rhythm is an important regulator of brown adipose tissue function.
Kroon J, Schilperoort M, In Het Panhuis W, van den Berg R, van Doeselaar L, Verzijl CRC, van Trigt N, Mol IM, Sips HHCM, van den Heuvel JK, Koorneef LL, van der Sluis RJ, Fenzl A, Kiefer FW, Vettorazzi S, Tuckermann JP, Biermasz NR, Meijer OC, Rensen PCN, Kooijman S. Kroon J, et al. Among authors: tuckermann jp. Mol Metab. 2021 May;47:101179. doi: 10.1016/j.molmet.2021.101179. Epub 2021 Feb 3. Mol Metab. 2021. PMID: 33548499 Free PMC article.
In a mouse model of hyperlipidemia and metabolic syndrome, long-term experimental flattening of corticosterone - and thus rhythm in BAT function - resulted in adiposity. ...
In a mouse model of hyperlipidemia and metabolic syndrome, long-term experimental flattening of corticosterone - and thus rhythm in B …
Leukemia inhibitory factor treatment attenuates the detrimental effects of glucocorticoids on bone in mice.
Lee S, Liu P, Ahmad M, Tuckermann JP. Lee S, et al. Among authors: tuckermann jp. Bone. 2021 Apr;145:115843. doi: 10.1016/j.bone.2021.115843. Epub 2021 Jan 9. Bone. 2021. PMID: 33429108
Glucocorticoids (GCs) are widely used drugs for the treatment of inflammatory and autoimmune diseases. However, a severe side effect induced by long-term GC therapy is osteoporosis. Leukemia inhibitory factor (LIF) - a glycoprotein 130 (gp130) dependent cytokine and member …
Glucocorticoids (GCs) are widely used drugs for the treatment of inflammatory and autoimmune diseases. However, a severe side effect induced …
Dicer ablation in osteoblasts by Runx2 driven cre-loxP recombination affects bone integrity, but not glucocorticoid-induced suppression of bone formation.
Liu P, Baumgart M, Groth M, Wittmann J, Jäck HM, Platzer M, Tuckermann JP, Baschant U. Liu P, et al. Among authors: tuckermann jp. Sci Rep. 2016 Aug 24;6:32112. doi: 10.1038/srep32112. Sci Rep. 2016. PMID: 27554624 Free PMC article.
Glucocorticoid-induced osteoporosis (GIO) is one of the major side effects of long-term glucocorticoid (GC) therapy mediated mainly via the suppression of bone formation and osteoblast differentiation independently of GC receptor (GR) dimerization. ...
Glucocorticoid-induced osteoporosis (GIO) is one of the major side effects of long-term glucocorticoid (GC) therapy mediated mainly v …
Molecular Actions of Glucocorticoids in Cartilage and Bone During Health, Disease, and Steroid Therapy.
Hartmann K, Koenen M, Schauer S, Wittig-Blaich S, Ahmad M, Baschant U, Tuckermann JP. Hartmann K, et al. Among authors: tuckermann jp. Physiol Rev. 2016 Apr;96(2):409-47. doi: 10.1152/physrev.00011.2015. Physiol Rev. 2016. PMID: 26842265 Free article. Review.
Cartilage and bone are severely affected by glucocorticoids (GCs), steroid hormones that are frequently used to treat inflammatory diseases. Major complications associated with long-term steroid therapy include impairment of cartilaginous bone growth and GC-induced osteopo …
Cartilage and bone are severely affected by glucocorticoids (GCs), steroid hormones that are frequently used to treat inflammatory diseases. …
The glucocorticoid receptor in inflammatory processes: transrepression is not enough.
Hübner S, Dejager L, Libert C, Tuckermann JP. Hübner S, et al. Among authors: tuckermann jp. Biol Chem. 2015 Nov;396(11):1223-31. doi: 10.1515/hsz-2015-0106. Biol Chem. 2015. PMID: 25910399 Review.
However, steroid therapies are accompanied by severe side-effects during long-term treatment. The dogma that transrepression of genes, by tethering of the glucocorticoid receptor (GR) to DNA-bound pro-inflammatory transcription factors, is the main anti-inflammatory mechan …
However, steroid therapies are accompanied by severe side-effects during long-term treatment. The dogma that transrepression of genes …
Glucocorticoids attenuate acute graft-versus-host disease by suppressing the cytotoxic capacity of CD8(+) T cells.
Theiss-Suennemann J, Jörß K, Messmann JJ, Reichardt SD, Montes-Cobos E, Lühder F, Tuckermann JP, AWolff H, Dressel R, Gröne HJ, Strauß G, Reichardt HM. Theiss-Suennemann J, et al. Among authors: tuckermann jp. J Pathol. 2015 Mar;235(4):646-55. doi: 10.1002/path.4475. Epub 2015 Jan 7. J Pathol. 2015. PMID: 25358639
Furthermore, serum levels of IL-2, IFNgamma, and IL-17 were elevated and the cytotoxicity of CD8(+) T cells was enhanced after transfer of GR-deficient T cells. Short-term treatment with dexamethasone reduced cytokine secretion but neither impacted disease severity nor the …
Furthermore, serum levels of IL-2, IFNgamma, and IL-17 were elevated and the cytotoxicity of CD8(+) T cells was enhanced after transfer of G …
Estradiol increases hematopoietic stem and progenitor cells independent of its actions on bone.
Illing A, Liu P, Ostermay S, Schilling A, de Haan G, Krust A, Amling M, Chambon P, Schinke T, Tuckermann JP. Illing A, et al. Among authors: tuckermann jp. Haematologica. 2012 Aug;97(8):1131-5. doi: 10.3324/haematol.2011.052456. Epub 2012 Feb 27. Haematologica. 2012. PMID: 22371175 Free PMC article.
Hematopoietic progenitors capable of reconstituting lethally irradiated mice are increased by enhanced cell cycle entry, leading to a diminished long-term reconstitution potential after serial transplantation. We demonstrate that estradiol action on stromal cells potently …
Hematopoietic progenitors capable of reconstituting lethally irradiated mice are increased by enhanced cell cycle entry, leading to a dimini …
Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor.
Rauch A, Seitz S, Baschant U, Schilling AF, Illing A, Stride B, Kirilov M, Mandic V, Takacz A, Schmidt-Ullrich R, Ostermay S, Schinke T, Spanbroek R, Zaiss MM, Angel PE, Lerner UH, David JP, Reichardt HM, Amling M, Schütz G, Tuckermann JP. Rauch A, et al. Among authors: tuckermann jp. Cell Metab. 2010 Jun 9;11(6):517-31. doi: 10.1016/j.cmet.2010.05.005. Cell Metab. 2010. PMID: 20519123 Free article.
Development of osteoporosis severely complicates long-term glucocorticoid (GC) therapy. Using a Cre-transgenic mouse line, we now demonstrate that GCs are unable to repress bone formation in the absence of glucocorticoid receptor (GR) expression in osteoblasts as they beco …
Development of osteoporosis severely complicates long-term glucocorticoid (GC) therapy. Using a Cre-transgenic mouse line, we now dem …
Keratinocyte-specific onset of serine protease BSSP expression in experimental carcinogenesis.
Breitenbach U, Tuckermann JP, Gebhardt C, Richter KH, Fürstenberger G, Christofori G, Angel P. Breitenbach U, et al. Among authors: tuckermann jp. J Invest Dermatol. 2001 Sep;117(3):634-40. doi: 10.1046/j.0022-202x.2001.01437.x. J Invest Dermatol. 2001. PMID: 11564170 Free article.
In an effort to identify target genes whose expression is associated with skin tumorigenesis we combined elements of suppression subtractive hybridization with differential screening to isolate genes that are differentially upregulated in mouse skin after short-term treatm …
In an effort to identify target genes whose expression is associated with skin tumorigenesis we combined elements of suppression subtractive …