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Beyond FOXP3: a 20-year journey unravelling human regulatory T-cell heterogeneity.
Santosh Nirmala S, Kayani K, Gliwiński M, Hu Y, Iwaszkiewicz-Grześ D, Piotrowska-Mieczkowska M, Sakowska J, Tomaszewicz M, Marín Morales JM, Lakshmi K, Marek-Trzonkowska NM, Trzonkowski P, Oo YH, Fuchs A. Santosh Nirmala S, et al. Among authors: trzonkowski p. Front Immunol. 2024 Jan 12;14:1321228. doi: 10.3389/fimmu.2023.1321228. eCollection 2023. Front Immunol. 2024. PMID: 38283365 Free PMC article. Review.
However, it is only in the last three decades that we have identified what we now term regulatory T-cells (Tregs), and subsequently elucidated and crystallized our understanding of them. ...
However, it is only in the last three decades that we have identified what we now term regulatory T-cells (Tregs), and subsequently e …
Ageing-resembling phenotype of long-term allogeneic hematopoietic cells recipients compared to their donors.
Czarnogórski MC, Sakowska J, Maziewski M, Zieliński M, Piekarska A, Obuchowski I, Młyński M, Dutka M, Sadowska-Klasa A, Zarzycka E, Bieniaszewska M, Trzonkowski P, Witkowski JM, Hellmann A, Ruckemann-Dziurdzińska K, Zaucha JM. Czarnogórski MC, et al. Among authors: trzonkowski p. Immun Ageing. 2022 Nov 2;19(1):51. doi: 10.1186/s12979-022-00308-6. Immun Ageing. 2022. PMID: 36324179 Free PMC article.
CONCLUSION: Our data do not support the initial hypothesis of accelerated aging in the long term all-HCT recipients with the exception of the recipients lymphocytes (mainly CD8(+)) which present some molecular features, characteristic for physiological ageing (telomeric sh …
CONCLUSION: Our data do not support the initial hypothesis of accelerated aging in the long term all-HCT recipients with the exceptio …
Intestinal Microbiota in Common Chronic Inflammatory Disorders Affecting Children.
Torun A, Hupalowska A, Trzonkowski P, Kierkus J, Pyrzynska B. Torun A, et al. Among authors: trzonkowski p. Front Immunol. 2021 Jun 7;12:642166. doi: 10.3389/fimmu.2021.642166. eCollection 2021. Front Immunol. 2021. PMID: 34163468 Free PMC article. Review.
Although constant efforts are being made to maximize the quality of life for children in the long-term, sustained improvements are still difficult to achieve. Additional challenges are the changing physiology associated with growth and development of children, a population …
Although constant efforts are being made to maximize the quality of life for children in the long-term, sustained improvements are st …
Immune Status Against Hepatitis B in Patients After Allogeneic Hematopoietic Cell Transplantation-Factors Affecting Early and Long-Lasting Maintenance of Protective Anti-HBs Titers.
Piekarska A, Wisniewski P, Lewandowski K, Gil L, Trzonkowski P, Bieniaszewska M, Zaucha JM. Piekarska A, et al. Among authors: trzonkowski p. Front Immunol. 2020 Nov 24;11:586523. doi: 10.3389/fimmu.2020.586523. eCollection 2020. Front Immunol. 2020. PMID: 33335530 Free PMC article.
We conducted a prospective study to assess clinical and immunological parameters that would determine the response and long-term maintenance of protective antibody titers upon the hepatitis B virus (HBV) vaccination after HCT. ...
We conducted a prospective study to assess clinical and immunological parameters that would determine the response and long-term main …
Factors affecting long-term efficacy of T regulatory cell-based therapy in type 1 diabetes.
Marek-Trzonkowska N, Myśliwiec M, Iwaszkiewicz-Grześ D, Gliwiński M, Derkowska I, Żalińska M, Zieliński M, Grabowska M, Zielińska H, Piekarska K, Jaźwińska-Curyłło A, Owczuk R, Szadkowska A, Wyka K, Witkowski P, Młynarski W, Jarosz-Chobot P, Bossowski A, Siebert J, Trzonkowski P. Marek-Trzonkowska N, et al. Among authors: trzonkowski p. J Transl Med. 2016 Dec 1;14(1):332. doi: 10.1186/s12967-016-1090-7. J Transl Med. 2016. PMID: 27903296 Free PMC article. Clinical Trial.
Clinical Use of Tolerogenic Dendritic Cells-Harmonization Approach in European Collaborative Effort.
Ten Brinke A, Hilkens CM, Cools N, Geissler EK, Hutchinson JA, Lombardi G, Lord P, Sawitzki B, Trzonkowski P, Van Ham SM, Martinez-Caceres EM. Ten Brinke A, et al. Among authors: trzonkowski p. Mediators Inflamm. 2015;2015:471719. doi: 10.1155/2015/471719. Epub 2015 Dec 24. Mediators Inflamm. 2015. PMID: 26819498 Free PMC article. Review.
Accumulating knowledge on immune mechanisms has led to the development of tolerogenic dendritic cells (tolDC), with the specific objective to restrain unwanted immune reactions in the long term. The first clinical trials with tolDC have recently been conducted and more tol …
Accumulating knowledge on immune mechanisms has led to the development of tolerogenic dendritic cells (tolDC), with the specific objective t …
[Insulin secretion in the early phase of type 1 diabetes mellitus (T1DM) and new hopes for maintaining it through therapy].
Żalińska M, Szmigiero-Kawko M, Brandt A, Trzonkowski P, Myśliwiec M. Żalińska M, et al. Among authors: trzonkowski p. Pediatr Endocrinol Diabetes Metab. 2016;22(3). doi: 10.18544/PEDM-22.03.0059. Pediatr Endocrinol Diabetes Metab. 2016. PMID: 28633161 Free article. Review. Polish.
At present, the most important factors that help sustain insulin secretion at the early stage of the disease and have the potential to reduce the risk or even prevent long-term diabetic complications include early diagnosis, early initiation of the insulin therapy, an appr …
At present, the most important factors that help sustain insulin secretion at the early stage of the disease and have the potential to reduc …
Vitamin B6 status, immune response and inflammation markers in kidney transplant recipients treated with polyclonal anti-thymocyte globulin.
Jankowska M, Trzonkowski P, Dębska-Ślizień A, Marszałł M, Rutkowski B. Jankowska M, et al. Among authors: trzonkowski p. Transplant Proc. 2014 Oct;46(8):2631-5. doi: 10.1016/j.transproceed.2014.08.009. Transplant Proc. 2014. PMID: 25380882
Treatment with polyclonal anti-thymocyte globulin (ATG) is associated with long-term changes in inflammatory and immune parameters. It is not known if ATG therapy also may have an impact on vitamin B6 status in kidney transplant recipients. ...
Treatment with polyclonal anti-thymocyte globulin (ATG) is associated with long-term changes in inflammatory and immune parameters. I …
Clinical application of regulatory T cells in type 1 diabetes.
Marek-Trzonkowska N, Myśliwec M, Siebert J, Trzonkowski P. Marek-Trzonkowska N, et al. Among authors: trzonkowski p. Pediatr Diabetes. 2013 Aug;14(5):322-32. doi: 10.1111/pedi.12029. Epub 2013 Apr 30. Pediatr Diabetes. 2013. PMID: 23627860 Review.
Several clinical trials attempted to induce Tregs with various agents, and thus provide long-term tolerance of beta cells in DM1. Nevertheless, most of these studies have focused on clinical parameters (e.g. ...
Several clinical trials attempted to induce Tregs with various agents, and thus provide long-term tolerance of beta cells in DM1. Nev …
[Diagnostic value of specific anty-HLA alloantibodies before and after renal transplantation. Programs for highly sensitized recipients].
Zielińska H, Zieliński M, Moszkowska G, Debska-Slizień A, Jankowska MM, Rutkowski B, Trzonkowski P. Zielińska H, et al. Among authors: trzonkowski p. Postepy Hig Med Dosw (Online). 2009 Sep 21;63:435-48. Postepy Hig Med Dosw (Online). 2009. PMID: 19837986 Free article. Review. Polish.
The strong correlation between donor-specific antibodies (DSA) and graft rejection seen both immediately after transplantation and in long-term complications such as CAN (chronic allograft nephropathy) may be the simplest explanation for this effect. ...
The strong correlation between donor-specific antibodies (DSA) and graft rejection seen both immediately after transplantation and in long- …
12 results