Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

8 results

Filters applied: . Clear all
Page 1
Chemically defined and xenogeneic-free culture method for human epidermal keratinocytes on laminin-based matrices.
Tjin MS, Chua AWC, Tryggvason K. Tjin MS, et al. Among authors: tryggvason k. Nat Protoc. 2020 Feb;15(2):694-711. doi: 10.1038/s41596-019-0270-3. Epub 2020 Jan 15. Nat Protoc. 2020. PMID: 31942079
In the present protocol, we describe how to implement a defined, xeno-free culture system that supports long-term ex vivo expansion of functional human epidermal keratinocytes. ...
In the present protocol, we describe how to implement a defined, xeno-free culture system that supports long-term ex vivo expansion o …
A systematic approach to the development of a safe live attenuated Zika vaccine.
Kwek SS, Watanabe S, Chan KR, Ong EZ, Tan HC, Ng WC, Nguyen MTX, Gan ES, Zhang SL, Chan KWK, Tan JH, Sessions OM, Manuel M, Pompon J, Chua C, Hazirah S, Tryggvason K, Vasudevan SG, Ooi EE. Kwek SS, et al. Among authors: tryggvason k. Nat Commun. 2018 Mar 12;9(1):1031. doi: 10.1038/s41467-018-03337-2. Nat Commun. 2018. PMID: 29531213 Free PMC article.
Zika virus (ZIKV) is a flavivirus that can cause congenital disease and requires development of an effective long-term preventative strategy. A replicative ZIKV vaccine with properties similar to the yellow fever 17D (YF17D) live-attenuated vaccine (LAV) would be advantage …
Zika virus (ZIKV) is a flavivirus that can cause congenital disease and requires development of an effective long-term preventative s …
Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment.
Rodin S, Antonsson L, Niaudet C, Simonson OE, Salmela E, Hansson EM, Domogatskaya A, Xiao Z, Damdimopoulou P, Sheikhi M, Inzunza J, Nilsson AS, Baker D, Kuiper R, Sun Y, Blennow E, Nordenskjöld M, Grinnemo KH, Kere J, Betsholtz C, Hovatta O, Tryggvason K. Rodin S, et al. Among authors: tryggvason k. Nat Commun. 2014;5:3195. doi: 10.1038/ncomms4195. Nat Commun. 2014. PMID: 24463987 Free article.
This matrix allows clonal derivation, clonal survival and long-term self-renewal of hES cells under completely chemically defined and xeno-free conditions without ROCK inhibitors. ...
This matrix allows clonal derivation, clonal survival and long-term self-renewal of hES cells under completely chemically defined and …
Nephrin is involved in podocyte maturation but not survival during glomerular development.
Doné SC, Takemoto M, He L, Sun Y, Hultenby K, Betsholtz C, Tryggvason K. Doné SC, et al. Among authors: tryggvason k. Kidney Int. 2008 Mar;73(6):697-704. doi: 10.1038/sj.ki.5002707. Epub 2007 Nov 28. Kidney Int. 2008. PMID: 18046313 Free article.
Nephrin, a major component of the glomerular slit diaphragm (SD), is both a structural protein as well as a signaling molecule influencing foot process (FP) formation and maintenance of podocyte integrity. Analyses of near-term embryonic kidneys showed normal cellular viab …
Nephrin, a major component of the glomerular slit diaphragm (SD), is both a structural protein as well as a signaling molecule influencing f …
Contribution of alpha6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with alpha4 integrins.
Qian H, Tryggvason K, Jacobsen SE, Ekblom M. Qian H, et al. Among authors: tryggvason k. Blood. 2006 May 1;107(9):3503-10. doi: 10.1182/blood-2005-10-3932. Epub 2006 Jan 26. Blood. 2006. PMID: 16439681 Free article.
A similar profound inhibition of long-term stem cell homing was obtained by using a function-blocking antibody against alpha4 integrin, studied in parallel. ...Our results provide the first evidence for a distinct functional role of integrin alpha6 receptor during hematopo …
A similar profound inhibition of long-term stem cell homing was obtained by using a function-blocking antibody against alpha4 integri …
Modulation of M(r) 72,000 and M(r) 92,000 type-IV collagenase (gelatinase A and B) gene expression by interferons alpha and gamma in human melanoma.
Hujanen ES, Väisänen A, Zheng A, Tryggvason K, Turpeenniemi-Hujanen T. Hujanen ES, et al. Among authors: tryggvason k. Int J Cancer. 1994 Aug 15;58(4):582-6. doi: 10.1002/ijc.2910580422. Int J Cancer. 1994. PMID: 8056455
Both M(r) 72,000 and M(r) 92,000 type-IV collagenase mRNAs were detectable in A2058 cells and mRNA levels for both gelatinases were significantly up-regulated in the cells treated for a short time period with either IFN-alpha or gamma. In contrast, a long-term treatment (7 …
Both M(r) 72,000 and M(r) 92,000 type-IV collagenase mRNAs were detectable in A2058 cells and mRNA levels for both gelatinases were signific …
Primary structure of the human laminin A chain. Limited expression in human tissues.
Nissinen M, Vuolteenaho R, Boot-Handford R, Kallunki P, Tryggvason K. Nissinen M, et al. Among authors: tryggvason k. Biochem J. 1991 Jun 1;276 ( Pt 2)(Pt 2):369-79. doi: 10.1042/bj2760369. Biochem J. 1991. PMID: 2049067 Free PMC article.
Northern-blot analysis was used to study the laminin A chain expression in the JAR cell line, full-term placenta and newborn-human tissues (kidney, spleen, lung, heart muscle, psoas muscle and diaphragm muscle). ...
Northern-blot analysis was used to study the laminin A chain expression in the JAR cell line, full-term placenta and newborn-human ti …