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"Bad Luck Mutations": DNA Mutations Are not the Whole Answer to Understanding Cancer Risk.
Trosko JE, Carruba G. Trosko JE, et al. Dose Response. 2017 Jun 30;15(2):1559325817716585. doi: 10.1177/1559325817716585. eCollection 2017 Apr-Jun. Dose Response. 2017. PMID: 28717349 Free PMC article.
While support for both interpretations provides some validity, both interpretations ignore several concepts of the multistage, multimechanism process of carcinogenesis, namely, (1) mutations can be generated by both "errors of DNA repair" and "errors of DNA replication," during t …
While support for both interpretations provides some validity, both interpretations ignore several concepts of the multistage, multimechanis …
Inhibition of gap junctional intercellular communication by noncoplanar polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action.
Machala M, Bláha L, Vondrácek J, Trosko JE, Scott J, Upham BL. Machala M, et al. Among authors: trosko je. Toxicol Sci. 2003 Nov;76(1):102-11. doi: 10.1093/toxsci/kfg209. Epub 2003 Aug 12. Toxicol Sci. 2003. PMID: 12915713
We then compared the effects of the coplanar PCB 126 (3,3',4,4',5-pentachlorobiphenyl) and the noncoplanar PCB 153 (2,2',4,4',5,5'-hexachlorobiphenyl) with effects of two model GJIC inhibitors, a tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth facto …
We then compared the effects of the coplanar PCB 126 (3,3',4,4',5-pentachlorobiphenyl) and the noncoplanar PCB 153 (2,2',4,4',5,5'-hexachlor …
Stimulation of cell proliferation and inhibition of gap junctional intercellular communication by linoleic acid.
Hayashi T, Matesic DF, Nomata K, Kang KS, Chang CC, Trosko JE. Hayashi T, et al. Among authors: trosko je. Cancer Lett. 1997 Jan 15;112(1):103-11. doi: 10.1016/S0304-3835(96)04553-3. Cancer Lett. 1997. PMID: 9029175
Addition of linoleic acid (0.01-3 mg/ml) to the low serum medium increased the growth rate and inhibited gap junctional intercellular communication (GJIC) in a dose-dependent manner. In a comparison of short-term and long-term treatments with LA, GJIC in short-te …
Addition of linoleic acid (0.01-3 mg/ml) to the low serum medium increased the growth rate and inhibited gap junctional intercellular commun …
Stem cell theory of carcinogenesis.
Trosko JE, Chang CC. Trosko JE, et al. Toxicol Lett. 1989 Dec;49(2-3):283-95. doi: 10.1016/0378-4274(89)90038-6. Toxicol Lett. 1989. PMID: 2690407 Review.
This understanding, plus recent results of the National Toxicology Bioassay program and of the studies of short-term tests for genotoxicity, has challenged the primary paradigm of 'carcinogens as mutagens' which governs our current risk assessment models. ...
This understanding, plus recent results of the National Toxicology Bioassay program and of the studies of short-term tests for genoto …
Characteristics of long-term human epithelial cell cultures derived from normal human fetal kidney.
Gibson-D'Ambrosio RE, Samuel M, Chang CC, Trosko JE, D'Ambrosio SM. Gibson-D'Ambrosio RE, et al. Among authors: trosko je. In Vitro Cell Dev Biol. 1987 Apr;23(4):279-87. doi: 10.1007/BF02623711. In Vitro Cell Dev Biol. 1987. PMID: 2437097
Epithelial cell cultures were prepared from normal human fetal kidney and established in long-term culture. The growth characteristics and production of keratin, and alkaline phosphatase (AP) and gamma-glutamyl transpeptidase (GGT) activities were compared in a modified mi …
Epithelial cell cultures were prepared from normal human fetal kidney and established in long-term culture. The growth characteristic …
Assessment of the carcinogenic potential of a proposed food coloring additive, laccaic acid, using short-term assays.
Dube DK, Loch-Caruso R, Trosko JE, Chakravarty I, Ghosh A, Loeb LA. Dube DK, et al. Among authors: trosko je. Cell Biol Toxicol. 1984 Oct;1(1):111-25. doi: 10.1007/BF00125569. Cell Biol Toxicol. 1984. PMID: 6401125
Laccaic acid is found to have no mutagenic activity as assessed by two short-term assays: the Salmonella/microsome mutagenicity test, and the phi X fidelity assay. ...
Laccaic acid is found to have no mutagenic activity as assessed by two short-term assays: the Salmonella/microsome mutagenicity test, …