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Understanding Cellular Redox Homeostasis: A Challenge for Precision Medicine.
Tretter V, Hochreiter B, Zach ML, Krenn K, Klein KU. Tretter V, et al. Int J Mol Sci. 2021 Dec 22;23(1):106. doi: 10.3390/ijms23010106. Int J Mol Sci. 2021. PMID: 35008532 Free PMC article. Review.
The scientific field of redox biology tries to understand how redox homeostasis is regulated and maintained and which mechanisms are derailed in diverse pathological developments of diseases, where oxidative or reductive stress is an issue. The term "oxidative stress" is d …
The scientific field of redox biology tries to understand how redox homeostasis is regulated and maintained and which mechanisms are deraile …
Ropivacaine Activates Multiple Proapoptotic and Inflammatory Signaling Pathways That Might Subsume to Trigger Epidural-Related Maternal Fever.
Wohlrab P, Boehme S, Kaun C, Wojta J, Spittler A, Saleh L, Knöfler M, Markstaller K, Klein KU, Tretter V. Wohlrab P, et al. Among authors: tretter v. Anesth Analg. 2020 Feb;130(2):321-331. doi: 10.1213/ANE.0000000000004402. Anesth Analg. 2020. PMID: 31498191
Dexamethasone reduced especially inflammatory effects, but as an inducer of mitophagy, had negative long-term effects on mitochondrial function. CONCLUSIONS: This study suggests that ropivacaine causes cellular injury and death in HUVECs and TBs via different signaling pat …
Dexamethasone reduced especially inflammatory effects, but as an inducer of mitophagy, had negative long-term effects on mitochondria …
20 Years of Secretagogin: Exocytosis and Beyond.
Maj M, Wagner L, Tretter V. Maj M, et al. Among authors: tretter v. Front Mol Neurosci. 2019 Feb 12;12:29. doi: 10.3389/fnmol.2019.00029. eCollection 2019. Front Mol Neurosci. 2019. PMID: 30853888 Free PMC article.
However, understanding CBPs and their interacting proteins is still of central interest. The post-genomic era has coined the term "calciomics," to describe a whole new research field, that engages in the identification and characterization of CBPs and their interactome. .. …
However, understanding CBPs and their interacting proteins is still of central interest. The post-genomic era has coined the term "ca …
Intermittent Hypoxia Activates Duration-Dependent Protective and Injurious Mechanisms in Mouse Lung Endothelial Cells.
Wohlrab P, Soto-Gonzales L, Benesch T, Winter MP, Lang IM, Markstaller K, Tretter V, Klein KU. Wohlrab P, et al. Among authors: tretter v. Front Physiol. 2018 Dec 6;9:1754. doi: 10.3389/fphys.2018.01754. eCollection 2018. Front Physiol. 2018. PMID: 30574096 Free PMC article.
At early timepoints and up to 24 h, many endothelial markers are unchanged in their expression and some indicators of injury are even downregulated. However, in the long-term, multiple signaling pathways are activated, that ultimately result in cellular inflammation, oxida …
At early timepoints and up to 24 h, many endothelial markers are unchanged in their expression and some indicators of injury are even downre …
Enhanced tonic inhibition influences the hypnotic and amnestic actions of the intravenous anesthetics etomidate and propofol.
Kretschmannova K, Hines RM, Revilla-Sanchez R, Terunuma M, Tretter V, Jurd R, Kelz MB, Moss SJ, Davies PA. Kretschmannova K, et al. Among authors: tretter v. J Neurosci. 2013 Apr 24;33(17):7264-73. doi: 10.1523/JNEUROSCI.5475-12.2013. J Neurosci. 2013. PMID: 23616535 Free PMC article.
Y365/7F mice exhibited a gender-specific enhancement of tonic inhibition in the dentate gyrus that was more sensitive to modulation by the anesthetic etomidate, together with a deficit in long-term potentiation. Consistent with this, female Y365/7F, but not male Y365/7F, m …
Y365/7F mice exhibited a gender-specific enhancement of tonic inhibition in the dentate gyrus that was more sensitive to modulation by the a …