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Inhaled recombinant GM-CSF reduces the need for whole lung lavage and improves gas exchange in autoimmune pulmonary alveolar proteinosis patients.
Campo I, Carey BC, Paracchini E, Kadija Z, De Silvestri A, Rodi G, De Amici M, Torre C, Zorzetto M, Griese M, Meloni F, Corsico AG, Trapnell BC, Mariani F. Campo I, et al. Among authors: trapnell bc. Eur Respir J. 2024 Jan 4;63(1):2301233. doi: 10.1183/13993003.01233-2023. Print 2024 Jan. Eur Respir J. 2024. PMID: 37973175 Free PMC article. Clinical Trial.
No serious adverse events were reported. CONCLUSIONS: This long-term, prospective, randomised trial demonstrated inhaled sargramostim following WLL reduced the requirement for WLL, improved lung function and was safe in aPAP patients. ...
No serious adverse events were reported. CONCLUSIONS: This long-term, prospective, randomised trial demonstrated inhaled sargramostim …
A murine model of hereditary pulmonary alveolar proteinosis caused by homozygous Csf2ra gene disruption.
Shima K, Arumugam P, Sallese A, Horio Y, Ma Y, Trapnell C, Wessendarp M, Chalk C, McCarthy C, Carey BC, Trapnell BC, Suzuki T. Shima K, et al. Among authors: trapnell bc. Am J Physiol Lung Cell Mol Physiol. 2022 Mar 1;322(3):L438-L448. doi: 10.1152/ajplung.00175.2021. Epub 2022 Jan 19. Am J Physiol Lung Cell Mol Physiol. 2022. PMID: 35043685 Free PMC article.
Pulmonary macrophage transplantation (PMT) without myeloablation resulted in long-term engraftment, restoration of GM-CSF responsiveness to AMs, and a safe and durable treatment effect that lasted for the duration of the experiment (6 mo). ...
Pulmonary macrophage transplantation (PMT) without myeloablation resulted in long-term engraftment, restoration of GM-CSF responsiven …
Long-Term Safety and Efficacy of Gene-Pulmonary Macrophage Transplantation Therapy of PAP in Csf2ra(-/-) Mice.
Arumugam P, Suzuki T, Shima K, McCarthy C, Sallese A, Wessendarp M, Ma Y, Meyer J, Black D, Chalk C, Carey B, Lachmann N, Moritz T, Trapnell BC. Arumugam P, et al. Among authors: trapnell bc. Mol Ther. 2019 Sep 4;27(9):1597-1611. doi: 10.1016/j.ymthe.2019.06.010. Epub 2019 Jul 2. Mol Ther. 2019. PMID: 31326401 Free PMC article.
Gene-PMT therapy resulted in a stable transgene integration and correction of GM-CSF signaling and functions in Csf2ra(-/-) macrophages in vitro and in vivo and resulted in engraftment and long-term persistence of gene-corrected macrophages in alveoli; restoration of pulmo …
Gene-PMT therapy resulted in a stable transgene integration and correction of GM-CSF signaling and functions in Csf2ra(-/-) macrophages in v …
Two-year follow-up of exposure, engineering controls, respiratory protection and respiratory health among workers at an indium-tin oxide (ITO) production and reclamation facility.
Harvey RR, Virji MA, Blackley BH, Stanton ML, Trapnell BC, Carey B, Healey T, Cummings KJ. Harvey RR, et al. Among authors: trapnell bc. Occup Environ Med. 2022 Aug;79(8):550-556. doi: 10.1136/oemed-2021-107897. Epub 2022 Apr 12. Occup Environ Med. 2022. PMID: 35414568 Free PMC article.
OBJECTIVES: To determine whether engineering controls and respiratory protection had measurable short-term impact on indium exposure and respiratory health among current indium-tin oxide production and reclamation facility workers. ...Ongoing medical monitoring of indium-e …
OBJECTIVES: To determine whether engineering controls and respiratory protection had measurable short-term impact on indium exposure …
Clinical Significance of Interferon-γ Neutralizing Autoantibodies Against Disseminated Nontuberculous Mycobacterial Disease.
Aoki A, Sakagami T, Yoshizawa K, Shima K, Toyama M, Tanabe Y, Moro H, Aoki N, Watanabe S, Koya T, Hasegawa T, Morimoto K, Kurashima A, Hoshino Y, Trapnell BC, Kikuchi T. Aoki A, et al. Among authors: trapnell bc. Clin Infect Dis. 2018 Apr 3;66(8):1239-1245. doi: 10.1093/cid/cix996. Clin Infect Dis. 2018. PMID: 29126235
Diagnosis of disseminated NTM requires a high degree of suspicion and can be improved by measuring serum nIFNgamma-autoAb titer. Long-term antibiotic therapy helps prevent recrudescent NTM infection....
Diagnosis of disseminated NTM requires a high degree of suspicion and can be improved by measuring serum nIFNgamma-autoAb titer. Long-ter
Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression.
Mueller C, Chulay JD, Trapnell BC, Humphries M, Carey B, Sandhaus RA, McElvaney NG, Messina L, Tang Q, Rouhani FN, Campbell-Thompson M, Fu AD, Yachnis A, Knop DR, Ye GJ, Brantly M, Calcedo R, Somanathan S, Richman LP, Vonderheide RH, Hulme MA, Brusko TM, Wilson JM, Flotte TR. Mueller C, et al. Among authors: trapnell bc. J Clin Invest. 2013 Dec;123(12):5310-8. doi: 10.1172/JCI70314. Epub 2013 Nov 15. J Clin Invest. 2013. PMID: 24231351 Free PMC article. Clinical Trial.
To determine whether rAAV vector expression can persist long term, we administered rAAV vectors expressing normal, M-type alpha-1 antitrypsin (M-AAT) to AAT-deficient subjects at various doses by multiple i.m. injections. ...
To determine whether rAAV vector expression can persist long term, we administered rAAV vectors expressing normal, M-type alpha-1 ant …
Assessment and management of pulmonary alveolar proteinosis in a reference center.
Campo I, Mariani F, Rodi G, Paracchini E, Tsana E, Piloni D, Nobili I, Kadija Z, Corsico A, Cerveri I, Chalk C, Trapnell BC, Braschi A, Tinelli C, Luisetti M. Campo I, et al. Among authors: trapnell bc. Orphanet J Rare Dis. 2013 Mar 13;8:40. doi: 10.1186/1750-1172-8-40. Orphanet J Rare Dis. 2013. PMID: 23497546 Free PMC article.
Pulmonary alveolar proteinosis (PAP) is a term defining an ultra-rare group of disorders characterised by a perturbation in surfactant homeostasis, resulting in its accumulation within airspaces and impaired gas transfer. ...With reference to the PAP clinical course, in 29 …
Pulmonary alveolar proteinosis (PAP) is a term defining an ultra-rare group of disorders characterised by a perturbation in surfactan …
Accelerating Scientific Advancement for Pediatric Rare Lung Disease Research. Report from a National Institutes of Health-NHLBI Workshop, September 3 and 4, 2015.
Young LR, Trapnell BC, Mandl KD, Swarr DT, Wambach JA, Blaisdell CJ. Young LR, et al. Among authors: trapnell bc. Ann Am Thorac Soc. 2016 Dec;13(12):385-393. doi: 10.1513/AnnalsATS.201605-402OT. Ann Am Thorac Soc. 2016. PMID: 27925785 Free PMC article.
Pediatric rare lung disease (PRLD) is a term that refers to a heterogeneous group of rare disorders in children. ...
Pediatric rare lung disease (PRLD) is a term that refers to a heterogeneous group of rare disorders in children. ...
Early changes in clinical, functional, and laboratory biomarkers in workers at risk of indium lung disease.
Cummings KJ, Virji MA, Trapnell BC, Carey B, Healey T, Kreiss K. Cummings KJ, et al. Among authors: trapnell bc. Ann Am Thorac Soc. 2014 Nov;11(9):1395-403. doi: 10.1513/AnnalsATS.201407-346OC. Ann Am Thorac Soc. 2014. PMID: 25295756 Free PMC article.
However, the early effects of exposure on the lungs are not well understood. OBJECTIVES: To determine the relationship between short-term occupational exposures to indium compounds and the development of early lung abnormalities. ...CONCLUSIONS: In indium-tin oxide facilit …
However, the early effects of exposure on the lungs are not well understood. OBJECTIVES: To determine the relationship between short-term
Adenovirus-mediated gene transfer to the respiratory tract of fetal sheep in utero.
Vincent MC, Trapnell BC, Baughman RP, Wert SE, Whitsett JA, Iwamoto HS. Vincent MC, et al. Among authors: trapnell bc. Hum Gene Ther. 1995 Aug;6(8):1019-28. doi: 10.1089/hum.1995.6.8-1019. Hum Gene Ther. 1995. PMID: 7578414
We instilled Av1LacZ4 (1.5 x 10(11) plaque-forming units, n = 10) or saline (n = 2) intratracheally to chronically instrumented fetal sheep at 112-134 days gestation (term = 145 days). Lung fluid was collected before and after Av1LacZ4 administration for cytological analys …
We instilled Av1LacZ4 (1.5 x 10(11) plaque-forming units, n = 10) or saline (n = 2) intratracheally to chronically instrumented fetal sheep …
12 results