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Defining the epigenetic status of blood cells using a cyanine-based fluorescent probe for PRMT1.
Su H, Sun CW, Liu SM, He X, Hu H, Pawlik KM, Townes TM, Han X, Klug CA, Henary M, Chen Y, Li L, Zheng YG, Zhao X. Su H, et al. Among authors: townes tm. Blood Adv. 2018 Nov 13;2(21):2829-2836. doi: 10.1182/bloodadvances.2018020727. Blood Adv. 2018. PMID: 30373889 Free PMC article.
Importantly, E84 staining has no apparent negative effect on the proliferation of the labeled cells. Given that long-term hematopoietic stem cells (LT-HSCs) produce low levels of PRMT1, we used E84 to sort LT-HSCs from mouse bone marrow. ...
Importantly, E84 staining has no apparent negative effect on the proliferation of the labeled cells. Given that long-term hematopoiet …
Bone Marrow Transplantation after Nonmyeloablative Treosulfan Conditioning Is Curative in a Murine Model of Sickle Cell Disease.
Devadasan D, Sun CW, Westin ER, Wu LC, Pawlik KM, Townes TM, Goldman FD. Devadasan D, et al. Among authors: townes tm. Biol Blood Marrow Transplant. 2018 Aug;24(8):1554-1562. doi: 10.1016/j.bbmt.2018.04.011. Epub 2018 Apr 21. Biol Blood Marrow Transplant. 2018. PMID: 29684562 Free article.
Conditioning with treosulfan alone at nonmyeloablative dosing (3.6 g/kg), followed by transplantation with syngeneic BM donor cells, permitted long-term mixed-donor chimerism. Level of chimerism correlated with improvement in hematologic parameters, normalization of urine …
Conditioning with treosulfan alone at nonmyeloablative dosing (3.6 g/kg), followed by transplantation with syngeneic BM donor cells, permitt …
Long-Term Endothelin-A Receptor Antagonism Provides Robust Renal Protection in Humanized Sickle Cell Disease Mice.
Kasztan M, Fox BM, Speed JS, De Miguel C, Gohar EY, Townes TM, Kutlar A, Pollock JS, Pollock DM. Kasztan M, et al. Among authors: townes tm. J Am Soc Nephrol. 2017 Aug;28(8):2443-2458. doi: 10.1681/ASN.2016070711. Epub 2017 Mar 27. J Am Soc Nephrol. 2017. PMID: 28348063 Free PMC article.
Sickle cell disease (SCD)-associated nephropathy is a major source of morbidity and mortality in patients because of the lack of efficacious treatments targeting renal manifestations of the disease. Here, we describe a long-term treatment strategy with the selective endoth …
Sickle cell disease (SCD)-associated nephropathy is a major source of morbidity and mortality in patients because of the lack of efficacious …
Correction of a mouse model of sickle cell disease: lentiviral/antisickling beta-globin gene transduction of unmobilized, purified hematopoietic stem cells.
Levasseur DN, Ryan TM, Pawlik KM, Townes TM. Levasseur DN, et al. Among authors: townes tm. Blood. 2003 Dec 15;102(13):4312-9. doi: 10.1182/blood-2003-04-1251. Epub 2003 Aug 21. Blood. 2003. PMID: 12933581 Free article.
Although sickle cell anemia was the first hereditary disease to be understood at the molecular level, there is still no adequate long-term treatment. Allogeneic bone marrow transplantation is the only available cure, but this procedure is limited to a minority of patients …
Although sickle cell anemia was the first hereditary disease to be understood at the molecular level, there is still no adequate long-ter …
Correction of phenotype in a thalassemia mouse model using a nonmyeloablative marrow transplantation regimen.
Bradley MB, Sattler RM, Raftopoulos H, Ward M, Grossman IR, Townes TM, Ryan TA, Bank A. Bradley MB, et al. Among authors: townes tm. Biol Blood Marrow Transplant. 2002;8(8):453-61. doi: 10.1053/bbmt.2002.v8.pm12234171. Biol Blood Marrow Transplant. 2002. PMID: 12234171 Free article.
Previous studies have shown high-level donor chimerism in nonmyeloablated non-thalassemic hosts. We have now studied the conditions for stable long-term engraftment of normal cells into a thalassemia mouse model that lead to high-level donor chimerism and correction of the …
Previous studies have shown high-level donor chimerism in nonmyeloablated non-thalassemic hosts. We have now studied the conditions for stab …
Lentiviral vector transduction of hematopoietic stem cells that mediate long-term reconstitution of lethally irradiated mice.
Chen W, Wu X, Levasseur DN, Liu H, Lai L, Kappes JC, Townes TM. Chen W, et al. Among authors: townes tm. Stem Cells. 2000;18(5):352-9. doi: 10.1634/stemcells.18-5-352. Stem Cells. 2000. PMID: 11007919
Lentiviral vectors efficiently transduce human CD34(+) cells that mediate long-term engraftment of nonobese diabetic/severe combined immunodeficient mice. ...
Lentiviral vectors efficiently transduce human CD34(+) cells that mediate long-term engraftment of nonobese diabetic/severe combined …
Stable transduction of recombinant adeno-associated virus into hematopoietic stem cells from normal and sickle cell patients.
Lubovy M, McCune S, Dong JY, Prchal JF, Townes TM, Prchal JT. Lubovy M, et al. Among authors: townes tm. Biol Blood Marrow Transplant. 1996 Feb;2(1):24-30. Biol Blood Marrow Transplant. 1996. PMID: 9078351
In the second set of experiments, infected cells were cultured for 6 weeks under conditions that maintain long-term culture-initiating cells (LTC-IC). Progenitors were plated in methylcellulose, and BFU-E were analyzed for lacZ DNA. ...
In the second set of experiments, infected cells were cultured for 6 weeks under conditions that maintain long-term culture-initiatin …