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Central Body Fat Distribution and Kidney Function after Living Kidney Donation.
Westenberg LB, Pol RA, van der Weijden J, de Borst MH, Bakker SJL, van Londen M; on behalf of the Transplant Lines Investigators. Westenberg LB, et al. Clin J Am Soc Nephrol. 2024 Apr 1;19(4):503-513. doi: 10.2215/CJN.0000000000000403. Epub 2024 Jan 8. Clin J Am Soc Nephrol. 2024. PMID: 38190119
This study aimed to determine whether BMI and central body fat distribution measures are associated with long-term kidney function after donor nephrectomy. We hypothesized that higher BMI, waist circumference (WC), and waist-to-height ratio (WHtR) were associated with lowe …
This study aimed to determine whether BMI and central body fat distribution measures are associated with long-term kidney function af …
Endobronchial Valve Treatment Does Not Cause Significant Nickel Deposition in Lung Tissue.
Roodenburg SA, Pouwels SD, Klooster K, Touw DJ, Slebos DJ. Roodenburg SA, et al. Among authors: touw dj. Respiration. 2023;102(6):454-457. doi: 10.1159/000529889. Epub 2023 May 10. Respiration. 2023. PMID: 37231891 Free article.
We found no significant difference in the median nickel concentration between the EBV-treated patient and the non-EBV-treated patient (0.270 vs. 0.328 mug/g, respectively, p = 0.693) and these concentrations were also comparable to previously published nickel concentrations in hu …
We found no significant difference in the median nickel concentration between the EBV-treated patient and the non-EBV-treated patient (0.270 …
Digital spacer data driven COPD inhaler adherence education: The OUTERSPACE proof-of-concept study.
Dierick BJH, Been-Buck S, Klemmeier T, Hagedoorn P, van de Hei SJ, Kerstjens HAM, Kocks JWH, Zijp TR, Wessels AMA, Touw DJ, van Boven JFM. Dierick BJH, et al. Among authors: touw dj. Respir Med. 2022 Sep;201:106940. doi: 10.1016/j.rmed.2022.106940. Epub 2022 Jul 31. Respir Med. 2022. PMID: 35933835 Free article.
In this proof-of-concept study, we assessed the usability of the digital spacer and explored its effects on inhaler technique, adherence, long-term systemic drug exposure and clinical outcomes in COPD. Usability was deemed high. ...This study demonstrates the digital space …
In this proof-of-concept study, we assessed the usability of the digital spacer and explored its effects on inhaler technique, adherence, lo …
Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD: A Randomized Crossover Trial.
Kramers BJ, Koorevaar IW, van Gastel MDA, van Goor H, Hallows KR, Heerspink HL, Li H, Leonhard WN, Peters DJM, Qiu J, Touw DJ, Gansevoort RT, Meijer E. Kramers BJ, et al. Among authors: touw dj. Clin J Am Soc Nephrol. 2022 Apr;17(4):507-517. doi: 10.2215/CJN.11260821. Epub 2022 Mar 21. Clin J Am Soc Nephrol. 2022. PMID: 35314480 Free PMC article. Clinical Trial.
Given these results, the effect of adding hydrochlorothiazide to tolvaptan was investigated on long-term kidney outcome in an animal experiment. Water intake in tolvaptan-hydrochlorothiazide cotreated mice was 35% lower than in mice treated with tolvaptan only. ...CONCLUSI …
Given these results, the effect of adding hydrochlorothiazide to tolvaptan was investigated on long-term kidney outcome in an animal …
Boron Intake and decreased risk of mortality in kidney transplant recipients.
Kremer D, Post A, Seidel U, Huebbe P, van der Veen Y, Groothof D, Gomes-Neto AW, Knobbe TJ, Lüersen K, Eisenga MF, Navis GJ, Rimbach G, Bakker SJL; TransplantLines Investigators. Kremer D, et al. Eur J Nutr. 2022 Mar;61(2):973-984. doi: 10.1007/s00394-021-02702-0. Epub 2021 Oct 22. Eur J Nutr. 2022. PMID: 34677681 Free PMC article.
PURPOSE: In a search for potentially modifiable factors to improve long-term outcome among kidney transplant recipients (KTR), we hypothesized that boron exposure is associated with improved long-term outcome in KTR. ...CONCLUSION: Boron may be an overlooked target …
PURPOSE: In a search for potentially modifiable factors to improve long-term outcome among kidney transplant recipients (KTR), we hyp …
The long-term safety of chronic azithromycin use in adult patients with cystic fibrosis, evaluating biomarkers for renal function, hepatic function and electrical properties of the heart.
Akkerman-Nijland AM, Möhlmann JE, Akkerman OW, Vd Vaart H, Majoor CJ, Rottier BL, Burgerhof JGM, Hak E, Koppelman GH, Touw DJ. Akkerman-Nijland AM, et al. Among authors: touw dj. Expert Opin Drug Saf. 2021 Aug;20(8):959-963. doi: 10.1080/14740338.2021.1932814. Epub 2021 Jun 7. Expert Opin Drug Saf. 2021. PMID: 34030570
Background: Azithromycin maintenance therapy is widely used in cystic fibrosis (CF), but little is known about its long-term safety. We investigated whether chronic azithromycin use is safe regarding renal function, hepatic cell toxicity and QTc-interval prolongation.Metho …
Background: Azithromycin maintenance therapy is widely used in cystic fibrosis (CF), but little is known about its long-term safety. …
Plasma cadmium is associated with increased risk of long-term kidney graft failure.
Sotomayor CG, Groothof D, Vodegel JJ, Eisenga MF, Knobbe TJ, IJmker J, Lammerts RGM, de Borst MH, Berger SP, Nolte IM, Rodrigo R, Slart RHJA, Navis GJ, Touw DJ, Bakker SJL. Sotomayor CG, et al. Among authors: touw dj. Kidney Int. 2021 May;99(5):1213-1224. doi: 10.1016/j.kint.2020.08.027. Epub 2020 Sep 14. Kidney Int. 2021. PMID: 32941876 Free article.
The kidney is one of the most sensitive organs to cadmium-induced toxicity, particularly in conditions of long-term oxidative stress. We hypothesized that, in kidney transplant recipients, nephrotoxic exposure to cadmium represents an overlooked hazard for optimal graft fu …
The kidney is one of the most sensitive organs to cadmium-induced toxicity, particularly in conditions of long-term oxidative stress. …
Endogenous urinary glucocorticoid metabolites and mortality in prednisolone-treated renal transplant recipients.
Vulto A, Minović I, de Vries LV, Timmermans AC, van Faassen M, Gomes Neto AW, Touw DJ, de Jong MFC, van Beek AP, Dullaart RPF, Navis G, Kema IP, Bakker SJL. Vulto A, et al. Among authors: touw dj. Clin Transplant. 2020 Apr;34(4):e13824. doi: 10.1111/ctr.13824. Epub 2020 Mar 3. Clin Transplant. 2020. PMID: 32052523 Free PMC article.
We aimed to investigate whether the endogenous glucocorticoid production and 11beta-HSD activities are altered in prednisolone-treated renal transplant recipients (RTR) compared with healthy controls and whether this has implications for long-term survival in RTR. METHODS: …
We aimed to investigate whether the endogenous glucocorticoid production and 11beta-HSD activities are altered in prednisolone-treated renal …
Circulating Arsenic is Associated with Long-Term Risk of Graft Failure in Kidney Transplant Recipients: A Prospective Cohort Study.
Sotomayor CG, Groothof D, Vodegel JJ, Gacitúa TA, Gomes-Neto AW, Osté MCJ, Pol RA, Ferreccio C, Berger SP, Chong G, Slart RHJA, Rodrigo R, Navis GJ, Touw DJ, Bakker SJL. Sotomayor CG, et al. Among authors: touw dj. J Clin Med. 2020 Feb 3;9(2):417. doi: 10.3390/jcm9020417. J Clin Med. 2020. PMID: 32028652 Free PMC article.
Pharmacokinetics and safety of tobramycin nebulization with the I-neb and PARI-LC Plus in children with cystic fibrosis: A randomized, crossover study.
van Velzen AJ, Uges JWF, Heijerman HGM, Arets BGM, Nuijsink M, van der Wiel-Kooij EC, van Maarseveen EM, van Zanten GA, Pullens B, Touw DJ, Janssens HM. van Velzen AJ, et al. Among authors: touw dj. Br J Clin Pharmacol. 2019 Sep;85(9):1984-1993. doi: 10.1111/bcp.13988. Epub 2019 Jul 10. Br J Clin Pharmacol. 2019. PMID: 31112621 Free PMC article. Clinical Trial.
CONCLUSIONS: Nebulization of 75 mg TIS with the I-neb in children with cystic fibrosis resulted in comparable systemic exposure to 300 mg TIS with the PARI-LC Plus and was well tolerated and preferred over the PARI-LC Plus. Long-term safety of TIS nebulization should be mo …
CONCLUSIONS: Nebulization of 75 mg TIS with the I-neb in children with cystic fibrosis resulted in comparable systemic exposure to 300 mg TI …
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