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Responses of the Soil Bacterial Community, Resistome, and Mobilome to a Decade of Annual Exposure to Macrolide Antibiotics.
Brown LP, Murray R, Scott A, Tien YC, Lau CH, Tai V, Topp E. Brown LP, et al. Among authors: topp e. Appl Environ Microbiol. 2022 Apr 26;88(8):e0031622. doi: 10.1128/aem.00316-22. Epub 2022 Apr 6. Appl Environ Microbiol. 2022. PMID: 35384705 Free PMC article.
However, the use of biosolids in agriculture, which are frequently contaminated with pharmaceuticals, such as macrolide antibiotics, may pose a risk to human health by selecting for antibiotic resistance genes that could be transferred to plant-based food destined for human consu …
However, the use of biosolids in agriculture, which are frequently contaminated with pharmaceuticals, such as macrolide antibiotics, may pos …
Effects of temperature and relative humidity in D2O on solid-state hydrogen deuterium exchange mass spectrometry (ssHDX-MS).
Tukra R, Gardner S, Topp EM. Tukra R, et al. Among authors: topp em. Int J Pharm. 2021 Mar 1;596:120263. doi: 10.1016/j.ijpharm.2021.120263. Epub 2021 Jan 21. Int J Pharm. 2021. PMID: 33486024
Data fitted best to a simplified model in which the slow exponential term was considered invariant with temperature and RH while the fast exponential term retained its temperature and RH dependence. ...
Data fitted best to a simplified model in which the slow exponential term was considered invariant with temperature and RH while the …
Impacts of Short-Term Antibiotic Withdrawal and Long-Term Judicious Antibiotic Use on Resistance Gene Abundance and Cecal Microbiota Composition on Commercial Broiler Chicken Farms in Quebec.
Turcotte C, Thibodeau A, Quessy S, Topp E, Beauchamp G, Fravalo P, Archambault M, Gaucher ML. Turcotte C, et al. Among authors: topp e. Front Vet Sci. 2020 Dec 21;7:547181. doi: 10.3389/fvets.2020.547181. eCollection 2020. Front Vet Sci. 2020. PMID: 33409294 Free PMC article.
The main objectives of the present study were to compare the abundance of antibiotic resistance-encoding genes, characterize the intestinal microbiota composition, and evaluate the presence of Clostridium perfringens, in six commercial poultry farms adopting short-term ant …
The main objectives of the present study were to compare the abundance of antibiotic resistance-encoding genes, characterize the intestinal …
Impacts of multi-year field exposure of agricultural soil to macrolide antibiotics on the abundance of antibiotic resistance genes and selected mobile genetic elements.
Lau CH, Tien YC, Stedtfeld RD, Topp E. Lau CH, et al. Among authors: topp e. Sci Total Environ. 2020 Jul 20;727:138520. doi: 10.1016/j.scitotenv.2020.138520. Epub 2020 Apr 6. Sci Total Environ. 2020. PMID: 32330714
The impact of a mixture of three macrolide antibiotics on the abundance of selected genes associated with antibiotic resistance and genetic mobility were determined in a long-term field experiment undertaken in London, Canada. Replicated plots received annual applications …
The impact of a mixture of three macrolide antibiotics on the abundance of selected genes associated with antibiotic resistance and genetic …
Explaining the accelerated degradation of ciprofloxacin, sulfamethazine, and erythromycin in different soil exposure scenarios by their aqueous extractability.
Goulas A, Sabourin L, Asghar F, Haudin CS, Benoit P, Topp E. Goulas A, et al. Among authors: topp e. Environ Sci Pollut Res Int. 2018 Jun;25(16):16236-16245. doi: 10.1007/s11356-018-1834-4. Epub 2018 Mar 29. Environ Sci Pollut Res Int. 2018. PMID: 29594886
Sulfamethazine and erythromycin were degraded in soils, with a larger fraction mineralized in the long-term exposed soil (20 and 65%, respectively) than in control soil (0.4 and 3%, respectively) after 7 days of incubation. In contrast, ciprofloxacin was not mineralized ne …
Sulfamethazine and erythromycin were degraded in soils, with a larger fraction mineralized in the long-term exposed soil (20 and 65%, …
Long-Term Exposure of Agricultural Soil to Veterinary Antibiotics Changes the Population Structure of Symbiotic Nitrogen-Fixing Rhizobacteria Occupying Nodules of Soybeans (Glycine max).
Revellin C, Hartmann A, Solanas S, Topp E. Revellin C, et al. Among authors: topp e. Appl Environ Microbiol. 2018 Apr 16;84(9):e00109-18. doi: 10.1128/AEM.00109-18. Print 2018 May 1. Appl Environ Microbiol. 2018. PMID: 29500255 Free PMC article.
Bradyrhizobia were phenotypically evaluated for their sensitivity to the antibiotics, and there was no association between in situ treatment and a decreased sensitivity to the drugs. Overall, long-term exposure to the antibiotic mixture altered the composition of bradyrhiz …
Bradyrhizobia were phenotypically evaluated for their sensitivity to the antibiotics, and there was no association between in situ treatment …
Solid-State Hydrogen-Deuterium Exchange Mass Spectrometry: Correlation of Deuterium Uptake and Long-Term Stability of Lyophilized Monoclonal Antibody Formulations.
Moorthy BS, Zarraga IE, Kumar L, Walters BT, Goldbach P, Topp EM, Allmendinger A. Moorthy BS, et al. Among authors: topp em. Mol Pharm. 2018 Jan 2;15(1):1-11. doi: 10.1021/acs.molpharmaceut.7b00504. Epub 2017 Nov 28. Mol Pharm. 2018. PMID: 29182876
Here, ssHDX-MS was applied to lyophilized monoclonal antibody (mAb) formulations and correlated to their long-term stability. After exposing lyophilized samples to D(2)O(g), the amount of deuterium incorporated at various time points was determined by mass spectrometry for …
Here, ssHDX-MS was applied to lyophilized monoclonal antibody (mAb) formulations and correlated to their long-term stability. After e …
Long-term antibiotic exposure in soil is associated with changes in microbial community structure and prevalence of class 1 integrons.
Cleary DW, Bishop AH, Zhang L, Topp E, Wellington EM, Gaze WH. Cleary DW, et al. Among authors: topp e. FEMS Microbiol Ecol. 2016 Oct;92(10):fiw159. doi: 10.1093/femsec/fiw159. Epub 2016 Aug 5. FEMS Microbiol Ecol. 2016. PMID: 27495240
This includes use as growth promoters or for prophylaxis and treatment of bacterial infection in intensively farmed livestock from where antibiotics can enter the environment as residues in manure. We characterised the impact of the long-term application of a mixture of ve …
This includes use as growth promoters or for prophylaxis and treatment of bacterial infection in intensively farmed livestock from where ant …
Biosolids applied to agricultural land: Influence on structural and functional endpoints of soil fauna on a short- and long-term scale.
Coors A, Edwards M, Lorenz P, Römbke J, Schmelz RM, Topp E, Waszak K, Wilkes G, Lapen DR. Coors A, et al. Among authors: topp e. Sci Total Environ. 2016 Aug 15;562:312-326. doi: 10.1016/j.scitotenv.2016.03.226. Epub 2016 Apr 19. Sci Total Environ. 2016. PMID: 27100012
It was only at this field site that potential evidence for a long-term impact of biosolids was detected with regard to two endpoints: earthworm abundance and structure of the nematode assemblage. ...Overall, the present study found only weak evidence for negative long-t …
It was only at this field site that potential evidence for a long-term impact of biosolids was detected with regard to two endpoints: …
Characterizing Protein Structure, Dynamics and Conformation in Lyophilized Solids.
Moorthy BS, Iyer LK, Topp EM. Moorthy BS, et al. Among authors: topp em. Curr Pharm Des. 2015;21(40):5845-53. doi: 10.2174/1381612821666151008150735. Curr Pharm Des. 2015. PMID: 26446463 Free PMC article. Review.
The long-term stability of protein therapeutics in the solid-state depends on the preservation of native structure during lyophilization and in the lyophilized powder. ...
The long-term stability of protein therapeutics in the solid-state depends on the preservation of native structure during lyophilizat …
21 results