Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

8 results

Filters applied: . Clear all
Page 1
Macrophage PD-1 associates with neutrophilia and reduced bacterial killing in early cystic fibrosis airway disease.
Margaroli C, Horati H, Garratt LW, Giacalone VD, Schofield C, Dittrich AS, Rosenow T, Dobosh BS, Lim HS, Frey DL, Veltman M, Silva GL, Brown MR, Schultz C, Tiddens HAWM, Ranganathan S, Chandler JD, Qiu P, Peng L, Scholte BJ, Mall MA, Kicic A, Guglani L, Stick SM, Janssens HM, Tirouvanziam R. Margaroli C, et al. Among authors: tirouvanziam r. J Cyst Fibros. 2022 Nov;21(6):967-976. doi: 10.1016/j.jcf.2022.06.001. Epub 2022 Jun 19. J Cyst Fibros. 2022. PMID: 35732550 Free article.
In cystic fibrosis (CF), neutrophils are recruited to the airways shortly after birth, and actively exocytose damaging enzymes prior to chronic infection, suggesting a potential defect in macrophage immunomodulatory function. ...In an in vitro model mimicking leukocyte rec …
In cystic fibrosis (CF), neutrophils are recruited to the airways shortly after birth, and actively exocytose damaging enzymes prior …
Transcriptional firing represses bactericidal activity in cystic fibrosis airway neutrophils.
Margaroli C, Moncada-Giraldo D, Gulick DA, Dobosh B, Giacalone VD, Forrest OA, Sun F, Gu C, Gaggar A, Kissick H, Wu R, Gibson G, Tirouvanziam R. Margaroli C, et al. Among authors: tirouvanziam r. Cell Rep Med. 2021 Apr 8;2(4):100239. doi: 10.1016/j.xcrm.2021.100239. eCollection 2021 Apr 20. Cell Rep Med. 2021. PMID: 33948572 Free PMC article.
Treatment by the RNA polymerase II and III inhibitor alpha-amanitin restores the expression of key antimicrobial genes and increases the bactericidal capacity of CF airway neutrophils in vitro and in short-term sputum cultures ex vivo. Broadly, our findings show that neutr …
Treatment by the RNA polymerase II and III inhibitor alpha-amanitin restores the expression of key antimicrobial genes and increases the bac …
Changes in airway inflammation with pseudomonas eradication in early cystic fibrosis.
Garratt LW, Breuer O, Schofield CJ, McLean SA, Laucirica DR, Tirouvanziam R, Clements BS, Kicic A, Ranganathan S, Stick SM, Cf OBOA. Garratt LW, et al. Among authors: tirouvanziam r. J Cyst Fibros. 2021 Nov;20(6):941-948. doi: 10.1016/j.jcf.2020.12.015. Epub 2021 Jan 15. J Cyst Fibros. 2021. PMID: 33461938 Free article.
Evaluating strategies to diminish neutrophilic inflammation is essential for improving long-term outcomes....
Evaluating strategies to diminish neutrophilic inflammation is essential for improving long-term outcomes....
MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients.
Dwir D, Giangreco B, Xin L, Tenenbaum L, Cabungcal JH, Steullet P, Goupil A, Cleusix M, Jenni R, Chtarto A, Baumann PS, Klauser P, Conus P, Tirouvanziam R, Cuenod M, Do KQ. Dwir D, et al. Among authors: tirouvanziam r. Mol Psychiatry. 2020 Nov;25(11):2889-2904. doi: 10.1038/s41380-019-0393-5. Epub 2019 Mar 25. Mol Psychiatry. 2020. PMID: 30911107 Free PMC article.
Blocking MMP9 activation prevented this sequence of alterations and rescued the normal maturation of PVI/PNN, even if performed after an additional insult that exacerbated the long term PVI/PNN impairments. MMP9 inhibition thus appears to be able to interrupt the vicious c …
Blocking MMP9 activation prevented this sequence of alterations and rescued the normal maturation of PVI/PNN, even if performed after an add …
Long-term treatment with oral N-acetylcysteine: affects lung function but not sputum inflammation in cystic fibrosis subjects. A phase II randomized placebo-controlled trial.
Conrad C, Lymp J, Thompson V, Dunn C, Davies Z, Chatfield B, Nichols D, Clancy J, Vender R, Egan ME, Quittell L, Michelson P, Antony V, Spahr J, Rubenstein RC, Moss RB, Herzenberg LA, Goss CH, Tirouvanziam R. Conrad C, et al. Among authors: tirouvanziam r. J Cyst Fibros. 2015 Mar;14(2):219-27. doi: 10.1016/j.jcf.2014.08.008. Epub 2014 Sep 13. J Cyst Fibros. 2015. PMID: 25228446 Free article. Clinical Trial.
The long-term impact of early adversity on late-life psychiatric disorders.
Gershon A, Sudheimer K, Tirouvanziam R, Williams LM, O'Hara R. Gershon A, et al. Among authors: tirouvanziam r. Curr Psychiatry Rep. 2013 Apr;15(4):352. doi: 10.1007/s11920-013-0352-9. Curr Psychiatry Rep. 2013. PMID: 23443532 Review.
The purpose of this review is to summarize and integrate the current research knowledge pertaining to the long-term effects of early adversity on psychiatric disorders, particularly in late life. ...
The purpose of this review is to summarize and integrate the current research knowledge pertaining to the long-term effects of early …
High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis.
Tirouvanziam R, Conrad CK, Bottiglieri T, Herzenberg LA, Moss RB, Herzenberg LA. Tirouvanziam R, et al. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4628-33. doi: 10.1073/pnas.0511304103. Epub 2006 Mar 13. Proc Natl Acad Sci U S A. 2006. PMID: 16537378 Free PMC article. Clinical Trial.
Pulmonary function measures were not improved, as expected with short-term treatment. After excluding data from subjects without baseline airway inflammation, positive treatment effects were more pronounced and included decreased sputum IL-8 levels (P = 0.032). ...
Pulmonary function measures were not improved, as expected with short-term treatment. After excluding data from subjects without base …
Ex vivo development of functional human lymph node and bronchus-associated lymphoid tissue.
Tirouvanziam R, Khazaal I, N'Sondé V, Peyrat MA, Lim A, de Bentzmann S, Fournié JJ, Bonneville M, Péault B. Tirouvanziam R, et al. Blood. 2002 Apr 1;99(7):2483-9. doi: 10.1182/blood.v99.7.2483. Blood. 2002. PMID: 11895783 Free article.
Overall, the bronchus-PLN cograft appears as a promising model for human bronchial immune development and function. Our study is the first to document long-term ex vivo maintenance of functional human lymph nodes as native appendices to mucosal tissue. ...
Overall, the bronchus-PLN cograft appears as a promising model for human bronchial immune development and function. Our study is the first t …