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PD-L1 Downregulation and DNA Methylation Inhibition for Molecular Therapy against Cancer Stem Cells in Hepatocellular Carcinoma.
Sukowati C, Cabral LKD, Anfuso B, Dituri F, Negro R, Giannelli G, Tiribelli C. Sukowati C, et al. Among authors: tiribelli c. Int J Mol Sci. 2023 Aug 29;24(17):13357. doi: 10.3390/ijms241713357. Int J Mol Sci. 2023. PMID: 37686163 Free PMC article.
In parallel, PD-L1 RNA silencing was performed in various human HCC cell lines, while combination therapy was performed in a co-culture system using long-term exposure of 5-Azacytidine (5-AZA) and an anti-PD-L1. Data from the mouse model showed that the expressions of Pdcd …
In parallel, PD-L1 RNA silencing was performed in various human HCC cell lines, while combination therapy was performed in a co-culture syst …
The physiology of bilirubin: health and disease equilibrium.
Vitek L, Hinds TD Jr, Stec DE, Tiribelli C. Vitek L, et al. Among authors: tiribelli c. Trends Mol Med. 2023 Apr;29(4):315-328. doi: 10.1016/j.molmed.2023.01.007. Epub 2023 Feb 22. Trends Mol Med. 2023. PMID: 36828710 Free PMC article. Review.
In addition to reactive oxygen species-scavenging activities, bilirubin has potent immunosuppressive effects associated with long-term pathophysiological sequelae. It has been recently recognized as a hormone with endocrine actions and interconnected effects on various cel …
In addition to reactive oxygen species-scavenging activities, bilirubin has potent immunosuppressive effects associated with long-term
MAFLD: A Consensus-Driven Proposed Nomenclature for Metabolic Associated Fatty Liver Disease.
Eslam M, Sanyal AJ, George J; International Consensus Panel. Eslam M, et al. Gastroenterology. 2020 May;158(7):1999-2014.e1. doi: 10.1053/j.gastro.2019.11.312. Epub 2020 Feb 8. Gastroenterology. 2020. PMID: 32044314 Review.
Experts reached consensus that NAFLD does not reflect current knowledge, and metabolic (dysfunction) associated fatty liver disease "MAFLD" was suggested as a more appropriate overarching term. This opens the door for efforts from the research community to update the nomen …
Experts reached consensus that NAFLD does not reflect current knowledge, and metabolic (dysfunction) associated fatty liver disease "MAFLD" …
Attenuation of neuro-inflammation improves survival and neurodegeneration in a mouse model of severe neonatal hyperbilirubinemia.
Vodret S, Bortolussi G, Iaconcig A, Martinelli E, Tiribelli C, Muro AF. Vodret S, et al. Among authors: tiribelli c. Brain Behav Immun. 2018 May;70:166-178. doi: 10.1016/j.bbi.2018.02.011. Epub 2018 Feb 16. Brain Behav Immun. 2018. PMID: 29458193
All pre-term newborns and a high proportion of term newborns develop neonatal jaundice. Neonatal jaundice is usually a benign condition and self-resolves within few days after birth. However, a combination of unfavorable complications may lead to acute hyperb …
All pre-term newborns and a high proportion of term newborns develop neonatal jaundice. Neonatal jaundice is usually a benign …
Comparison between Bilistick System and transcutaneous bilirubin in assessing total bilirubin serum concentration in jaundiced newborns.
Greco C, Iskander IF, Akmal DM, El Houchi SZ, Khairy DA, Bedogni G, Wennberg RP, Tiribelli C, Coda Zabetta CD. Greco C, et al. Among authors: tiribelli c. J Perinatol. 2017 Sep;37(9):1028-1031. doi: 10.1038/jp.2017.94. Epub 2017 Jun 15. J Perinatol. 2017. PMID: 28617429
OBJECTIVE: To compare the performance and accuracy of the JM-103 transcutaneous bilirubinometer and Bilistick System in measuring total serum bilirubin for the early identification of neonatal hyperbilirubinemia. STUDY DESIGN: The study was performed on 126 consecutive term
OBJECTIVE: To compare the performance and accuracy of the JM-103 transcutaneous bilirubinometer and Bilistick System in measuring total seru …
Nonalcoholic Fatty Liver Is Not Associated with the Relationship between Insulin Secretion and Insulin Sensitivity in Obese Children: Matched Case-Control Study.
Bedogni G, Mari A, De Col A, Marazzi N, Tiribelli C, Manco M, Sartorio A. Bedogni G, et al. Among authors: tiribelli c. Child Obes. 2016 Dec;12(6):426-431. doi: 10.1089/chi.2016.0141. Epub 2016 Aug 19. Child Obes. 2016. PMID: 27541280
When such interaction was removed from the models, the NAFLD term was not significant, implying commons intercepts for NAFLD(+) and NAFLD(-) children. ...
When such interaction was removed from the models, the NAFLD term was not significant, implying commons intercepts for NAFLD(+) and N …
Life-long correction of hyperbilirubinemia with a neonatal liver-specific AAV-mediated gene transfer in a lethal mouse model of Crigler-Najjar Syndrome.
Bortolussi G, Zentillin L, Vaníkova J, Bockor L, Bellarosa C, Mancarella A, Vianello E, Tiribelli C, Giacca M, Vitek L, Muro AF. Bortolussi G, et al. Among authors: tiribelli c. Hum Gene Ther. 2014 Sep;25(9):844-55. doi: 10.1089/hum.2013.233. Hum Gene Ther. 2014. PMID: 25072305 Free PMC article.
Taken together, our data support the concept that liver is the best organ for efficient and long-term CNSI gene therapy, and suggest that the use of extra-hepatic tissues should be coupled to the presence of bilirubin transporters....
Taken together, our data support the concept that liver is the best organ for efficient and long-term CNSI gene therapy, and suggest …
Bilistick: a low-cost point-of-care system to measure total plasma bilirubin.
Coda Zabetta CD, Iskander IF, Greco C, Bellarosa C, Demarini S, Tiribelli C, Wennberg RP. Coda Zabetta CD, et al. Among authors: tiribelli c. Neonatology. 2013;103(3):177-81. doi: 10.1159/000345425. Epub 2012 Dec 22. Neonatology. 2013. PMID: 23295342
METHODS: We compared plasma bilirubin levels in divided blood samples by clinical laboratories and by Bilistick at two medical centers serving term and near-term newborns from ethnically different populations. ...
METHODS: We compared plasma bilirubin levels in divided blood samples by clinical laboratories and by Bilistick at two medical centers servi …
A proteomic approach to the bilirubin-induced toxicity in neuronal cells reveals a protective function of DJ-1 protein.
Deganuto M, Cesaratto L, Bellarosa C, Calligaris R, Vilotti S, Renzone G, Foti R, Scaloni A, Gustincich S, Quadrifoglio F, Tiribelli C, Tell G. Deganuto M, et al. Among authors: tiribelli c. Proteomics. 2010 Apr;10(8):1645-57. doi: 10.1002/pmic.200900579. Proteomics. 2010. PMID: 20186750
Although newborns develop a physiological jaundice, in case of severe hyperbilirubinemia UCB may become neurotoxic causing severe long-term neuronal damages, also known as bilirubin encephalopathy. To investigate the mechanisms of UCB-induced neuronal toxicity, we used the …
Although newborns develop a physiological jaundice, in case of severe hyperbilirubinemia UCB may become neurotoxic causing severe long-te
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