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Advances in Neonatal Acute Kidney Injury.
Starr MC, Charlton JR, Guillet R, Reidy K, Tipple TE, Jetton JG, Kent AL, Abitbol CL, Ambalavanan N, Mhanna MJ, Askenazi DJ, Selewski DT, Harer MW; Neonatal Kidney Collaborative Board. Starr MC, et al. Among authors: tipple te. Pediatrics. 2021 Nov;148(5):e2021051220. doi: 10.1542/peds.2021-051220. Epub 2021 Oct 1. Pediatrics. 2021. PMID: 34599008 Review.
The natural course of neonatal AKI, along with the risk factors, mitigation strategies, and the role of AKI on short- and long-term outcomes, is becoming clearer. Specific progress has been made in identifying potential preventive strategies for AKI, such as the use of caf …
The natural course of neonatal AKI, along with the risk factors, mitigation strategies, and the role of AKI on short- and long-term o …
MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha.
Freeman A, Qiao L, Olave N, Rezonzew G, Gentle S, Halloran B, Pryhuber GS, Gaggar A, Tipple TE, Ambalavanan N, Lal CV. Freeman A, et al. Among authors: tipple te. Respir Res. 2021 Feb 17;22(1):57. doi: 10.1186/s12931-021-01654-7. Respir Res. 2021. PMID: 33596914 Free PMC article.
METHODS: Here we report a prospective cohort study of extremely preterm neonates wherein infants diagnosed with severe BPD expressed increased airway miR-219-5p and decreased platelet derived growth factor receptor alpha (PDGFR-alpha), a target of mir-219-5p and a key regulator o …
METHODS: Here we report a prospective cohort study of extremely preterm neonates wherein infants diagnosed with severe BPD expressed increas …
Aurothioglucose enhances proangiogenic pathway activation in lungs from room air and hyperoxia-exposed newborn mice.
Dunigan-Russell K, Lin V, Silverberg M, Wall SB, Li R, Gotham J, Nicola T, Sridharan A, Snowball J, Delaney C, Li Q, Tipple TE. Dunigan-Russell K, et al. Among authors: tipple te. Am J Physiol Lung Cell Mol Physiol. 2020 Jun 1;318(6):L1165-L1171. doi: 10.1152/ajplung.00086.2020. Epub 2020 Apr 15. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 32292070 Free PMC article.
Bronchopulmonary dysplasia (BPD), a long-term respiratory morbidity of prematurity, is characterized by attenuated alveolar and vascular development. ...The present studies evaluated the impact of the TXNRD1 inhibitor aurothioglucose (ATG) on pulmonary responses and gene e …
Bronchopulmonary dysplasia (BPD), a long-term respiratory morbidity of prematurity, is characterized by attenuated alveolar and vascu …
Preterm birth and neonatal acute kidney injury: implications on adolescent and adult outcomes.
Harer MW, Charlton JR, Tipple TE, Reidy KJ. Harer MW, et al. Among authors: tipple te. J Perinatol. 2020 Sep;40(9):1286-1295. doi: 10.1038/s41372-020-0656-7. Epub 2020 Apr 10. J Perinatol. 2020. PMID: 32277164 Review.
As a result of preterm birth, immature kidneys are exposed to interventions in the NICU that promote survival, but are nephrotoxic. ...For neonatal intensive care studies, we propose the inclusion of AKI as an important short-term morbidity outcome and CKD findings …
As a result of preterm birth, immature kidneys are exposed to interventions in the NICU that promote survival, but are nephrotoxic. . …
Attenuation of miR-17∼92 Cluster in Bronchopulmonary Dysplasia.
Rogers LK, Robbins M, Dakhlallah D, Yang Z, Lee LJ, Mikhail M, Nuovo G, Pryhuber GS, McGwin G, Marsh CB, Tipple TE. Rogers LK, et al. Among authors: tipple te. Ann Am Thorac Soc. 2015 Oct;12(10):1506-13. doi: 10.1513/AnnalsATS.201501-058OC. Ann Am Thorac Soc. 2015. PMID: 26291337 Free PMC article.
METHODS: miR-1792 cluster expression, promoter methylation, and DNA methyltransferase expression were determined in autopsy lung samples obtained from premature infants who died with bronchopulmonary dysplasia, or from term/near-term infants who died from nonrespira …
METHODS: miR-1792 cluster expression, promoter methylation, and DNA methyltransferase expression were determined in autopsy lung samples obt …
Prenatal inflammation exacerbates hyperoxia-induced functional and structural changes in adult mice.
Velten M, Britt RD Jr, Heyob KM, Welty SE, Eiberger B, Tipple TE, Rogers LK. Velten M, et al. Among authors: tipple te. Am J Physiol Regul Integr Comp Physiol. 2012 Aug 1;303(3):R279-90. doi: 10.1152/ajpregu.00029.2012. Epub 2012 Jun 20. Am J Physiol Regul Integr Comp Physiol. 2012. PMID: 22718803 Free PMC article.
Maternally derived inflammatory mediators, such as IL-6 and IL-8, contribute to preterm delivery, low birth weight, and respiratory insufficiency, which are routinely treated with oxygen. Premature infants are at risk for developing adult-onset cardiac, metabolic, and pulm …
Maternally derived inflammatory mediators, such as IL-6 and IL-8, contribute to preterm delivery, low birth weight, and respiratory i …