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Killing tumor-associated bacteria with a liposomal antibiotic generates neoantigens that induce anti-tumor immune responses.
Wang M, Rousseau B, Qiu K, Huang G, Zhang Y, Su H, Le Bihan-Benjamin C, Khati I, Artz O, Foote MB, Cheng YY, Lee KH, Miao MZ, Sun Y, Bousquet PJ, Hilmi M, Dumas E, Hamy AS, Reyal F, Lin L, Armistead PM, Song W, Vargason A, Arthur JC, Liu Y, Guo J, Zhou X, Nguyen J, He Y, Ting JP, Anselmo AC, Huang L. Wang M, et al. Among authors: ting jp. Nat Biotechnol. 2023 Sep 25. doi: 10.1038/s41587-023-01957-8. Online ahead of print. Nat Biotechnol. 2023. PMID: 37749267
Mouse CRC models colonized by tumor-promoting bacteria (Fusobacterium nucleatum spp.) or probiotics (Escherichia coli Nissle spp.) responded to LipoAgTNZ therapy, which enabled more than 70% long-term survival in two F. nucleatum-infected CRC models. The antibiotic treatme …
Mouse CRC models colonized by tumor-promoting bacteria (Fusobacterium nucleatum spp.) or probiotics (Escherichia coli Nissle spp.) responded …
Microparticle Delivery of a STING Agonist Enables Indirect Activation of NK Cells by Antigen-Presenting Cells.
Watkins-Schulz R, Batty CJ, Stiepel RT, Schmidt ME, Sandor AM, Chou WC, Ainslie KM, Bachelder EM, Ting JP. Watkins-Schulz R, et al. Among authors: ting jp. Mol Pharm. 2022 Sep 5;19(9):3125-3138. doi: 10.1021/acs.molpharmaceut.2c00207. Epub 2022 Aug 1. Mol Pharm. 2022. PMID: 35913984
In vivo, treatment with soluble cGAMP and cGAMP MPs both cause short-term activation, whereas only cGAMP MP treatment produces long-term changes in NK cell activation markers. ...
In vivo, treatment with soluble cGAMP and cGAMP MPs both cause short-term activation, whereas only cGAMP MP treatment produces long- …
Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites.
Guo H, Chou WC, Lai Y, Liang K, Tam JW, Brickey WJ, Chen L, Montgomery ND, Li X, Bohannon LM, Sung AD, Chao NJ, Peled JU, Gomes ALC, van den Brink MRM, French MJ, Macintyre AN, Sempowski GD, Tan X, Sartor RB, Lu K, Ting JPY. Guo H, et al. Among authors: ting jpy. Science. 2020 Oct 30;370(6516):eaay9097. doi: 10.1126/science.aay9097. Science. 2020. PMID: 33122357 Free PMC article.
In our study in mice, metabolomics revealed increased fecal concentrations of microbially derived propionate and tryptophan metabolites in elite-survivors. The administration of these metabolites caused long-term radioprotection, mitigation of hematopoietic and gastrointes …
In our study in mice, metabolomics revealed increased fecal concentrations of microbially derived propionate and tryptophan metabolites in e …
MyD88 provides a protective role in long-term radiation-induced lung injury.
Brickey WJ, Neuringer IP, Walton W, Hua X, Wang EY, Jha S, Sempowski GD, Yang X, Kirby SL, Tilley SL, Ting JP. Brickey WJ, et al. Among authors: ting jp. Int J Radiat Biol. 2012 Apr;88(4):335-47. doi: 10.3109/09553002.2012.652723. Epub 2012 Feb 6. Int J Radiat Biol. 2012. PMID: 22248128 Free PMC article.
The absence of MyD88 resulted in unresolved pulmonary infiltrate and enhanced collagen deposition plus elevated type 2 helper T cell (Th2) cytokines in long-term survivors of irradiation. CONCLUSIONS: These results based only on a gene deletion model suggest that alteratio …
The absence of MyD88 resulted in unresolved pulmonary infiltrate and enhanced collagen deposition plus elevated type 2 helper T cell (Th2) c …
Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1.
McElvania Tekippe E, Allen IC, Hulseberg PD, Sullivan JT, McCann JR, Sandor M, Braunstein M, Ting JP. McElvania Tekippe E, et al. Among authors: ting jp. PLoS One. 2010 Aug 20;5(8):e12320. doi: 10.1371/journal.pone.0012320. PLoS One. 2010. PMID: 20808838 Free PMC article.
However, in vivo Mtb aerosol infection of Nlrp3(-/-), Casp-1(-/-), and WT mice showed no differences in pulmonary IL-1beta production, bacterial burden, or long-term survival. In contrast, a significant role was observed for Pycard in host protection during chronic Mtb inf …
However, in vivo Mtb aerosol infection of Nlrp3(-/-), Casp-1(-/-), and WT mice showed no differences in pulmonary IL-1beta production, bacte …
Enhancement of DNA vaccine potency through coadministration of CIITA DNA with DNA vaccines via gene gun.
Kim D, Hoory T, Monie A, Ting JP, Hung CF, Wu TC. Kim D, et al. Among authors: ting jp. J Immunol. 2008 May 15;180(10):7019-27. doi: 10.4049/jimmunol.180.10.7019. J Immunol. 2008. PMID: 18453624 Free PMC article.
Vaccination with the combination vaccine also led to enhanced E6-specific CD8(+) memory T cells and to long-term protection against TC-1 tumors and prolonged survival in vaccinated mice. ...
Vaccination with the combination vaccine also led to enhanced E6-specific CD8(+) memory T cells and to long-term protection against T …
Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC.
Willingham SB, Bergstralh DT, O'Connor W, Morrison AC, Taxman DJ, Duncan JA, Barnoy S, Venkatesan MM, Flavell RA, Deshmukh M, Hoffman HM, Ting JP. Willingham SB, et al. Among authors: ting jp. Cell Host Microbe. 2007 Sep 13;2(3):147-59. doi: 10.1016/j.chom.2007.07.009. Cell Host Microbe. 2007. PMID: 18005730 Free PMC article.
While similar proteins mediate pathogen-induced cell death in plants, this report identifies cryopyrin as an important host regulator of programmed pathogen-induced necrosis in animals, a process we term pyronecrosis....
While similar proteins mediate pathogen-induced cell death in plants, this report identifies cryopyrin as an important host regulator of pro …
Combined donor specific transfusion and anti-CD154 therapy achieves airway allograft tolerance.
Chalermskulrat W, McKinnon KP, Brickey WJ, Neuringer IP, Park RC, Sterka DG, Long BR, McNeillie P, Noelle RJ, Ting JP, Aris RM. Chalermskulrat W, et al. Among authors: ting jp. Thorax. 2006 Jan;61(1):61-7. doi: 10.1136/thx.2005.047316. Epub 2005 Oct 27. Thorax. 2006. PMID: 16254057 Free PMC article.
BACKGROUND: The state of tolerance allows long term graft survival without immunosuppressants. Lung transplantation tolerance has not been consistently achieved in either small or large animal models. ...CONCLUSIONS: The DST/anti-CD154 protocol successfully induced and mai …
BACKGROUND: The state of tolerance allows long term graft survival without immunosuppressants. Lung transplantation tolerance has not …