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A human-based multi-gene signature enables quantitative drug repurposing for metabolic disease.
Timmons JA, Anighoro A, Brogan RJ, Stahl J, Wahlestedt C, Farquhar DG, Taylor-King J, Volmar CH, Kraus WE, Phillips SM. Timmons JA, et al. Elife. 2022 Jan 17;11:e68832. doi: 10.7554/eLife.68832. Elife. 2022. PMID: 35037854 Free PMC article.
Cross-referencing these results with the way existing drugs act on gene activity, highlighted 138 compounds that directly bind 73 proteins responsible for regulating insulin resistance pathways. Some of the drugs identified are suitable for short-term clinical studies, and …
Cross-referencing these results with the way existing drugs act on gene activity, highlighted 138 compounds that directly bind 73 proteins r …
A Practical and Time-Efficient High-Intensity Interval Training Program Modifies Cardio-Metabolic Risk Factors in Adults with Risk Factors for Type II Diabetes.
Phillips BE, Kelly BM, Lilja M, Ponce-González JG, Brogan RJ, Morris DL, Gustafsson T, Kraus WE, Atherton PJ, Vollaard NBJ, Rooyackers O, Timmons JA. Phillips BE, et al. Among authors: timmons ja. Front Endocrinol (Lausanne). 2017 Sep 8;8:229. doi: 10.3389/fendo.2017.00229. eCollection 2017. Front Endocrinol (Lausanne). 2017. PMID: 28943861 Free PMC article.
CONCLUSION: With a total time-commitment of <15 min per session and reliance on a practical ergometer protocol, 5-by-1 HIT offers a new solution to modulate cardio-metabolic risk factors in adults with pre-existing risk factors for type 2 diabetes while approximately meeting t …
CONCLUSION: With a total time-commitment of <15 min per session and reliance on a practical ergometer protocol, 5-by-1 HIT offers a new s …
Skin electroporation: effects on transgene expression, DNA persistence and local tissue environment.
Roos AK, Eriksson F, Timmons JA, Gerhardt J, Nyman U, Gudmundsdotter L, Bråve A, Wahren B, Pisa P. Roos AK, et al. Among authors: timmons ja. PLoS One. 2009 Sep 30;4(9):e7226. doi: 10.1371/journal.pone.0007226. PLoS One. 2009. PMID: 19789652 Free PMC article.
However, when the more immunogenic prostate specific antigen (PSA) was co-administered, PSA-specific T cells were induced and concurrently the luciferase expression became undetectable. Electroporation did not affect the long-term persistence of the PSA-expressing plasmid. …
However, when the more immunogenic prostate specific antigen (PSA) was co-administered, PSA-specific T cells were induced and concurrently t …
Muscle creatine loading in men.
Hultman E, Söderlund K, Timmons JA, Cederblad G, Greenhaff PL. Hultman E, et al. Among authors: timmons ja. J Appl Physiol (1985). 1996 Jul;81(1):232-7. doi: 10.1152/jappl.1996.81.1.232. J Appl Physiol (1985). 1996. PMID: 8828669 Clinical Trial.
This elevated tissue concentration can then be maintained by ingestion of 2 g/day thereafter. The ingestion of 3 g creatine/day is in the long term likely to be as effective at raising tissue levels as this higher dose....
This elevated tissue concentration can then be maintained by ingestion of 2 g/day thereafter. The ingestion of 3 g creatine/day is in the lo …
Submaximal running economy in run-trained pre-pubertal boys.
Unnithan VB, Timmons JA, Brogan RT, Paton JY, Rowland TW. Unnithan VB, et al. Among authors: timmons ja. J Sports Med Phys Fitness. 1996 Mar;36(1):16-23. J Sports Med Phys Fitness. 1996. PMID: 8699833
There is an increasing tendency for young children to participate in training and competitive running. The impact long-term training has upon stimulating functional physiological adaptation has yet to be fully understood. ...
There is an increasing tendency for young children to participate in training and competitive running. The impact long-term training …