Macrophage PD-1 associates with neutrophilia and reduced bacterial killing in early cystic fibrosis airway disease.
Margaroli C, Horati H, Garratt LW, Giacalone VD, Schofield C, Dittrich AS, Rosenow T, Dobosh BS, Lim HS, Frey DL, Veltman M, Silva GL, Brown MR, Schultz C, Tiddens HAWM, Ranganathan S, Chandler JD, Qiu P, Peng L, Scholte BJ, Mall MA, Kicic A, Guglani L, Stick SM, Janssens HM, Tirouvanziam R.
Margaroli C, et al. Among authors: tiddens hawm.
J Cyst Fibros. 2022 Nov;21(6):967-976. doi: 10.1016/j.jcf.2022.06.001. Epub 2022 Jun 19.
J Cyst Fibros. 2022.
PMID: 35732550
Free article.
In cystic fibrosis (CF), neutrophils are recruited to the airways shortly after birth, and actively exocytose damaging enzymes prior to chronic infection, suggesting a potential defect in macrophage immunomodulatory function. ...In an in vitro model mimicking leukocyte rec …
In cystic fibrosis (CF), neutrophils are recruited to the airways shortly after birth, and actively exocytose damaging enzymes prior …