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Highly Selective Lysine Acylation in Proteins Using a Lys-His Tag Sequence.
Kofoed C, Wu S, Sørensen KK, Treiberg T, Arnsdorf J, Bjørn SP, Jensen TL, Voldborg BG, Thygesen MB, Jensen KJ, Schoffelen S. Kofoed C, et al. Among authors: thygesen mb. Chemistry. 2022 Mar 10;28(15):e202200147. doi: 10.1002/chem.202200147. Epub 2022 Feb 17. Chemistry. 2022. PMID: 35099088
Herein, we report the peptide sequences His(n) -Lys-His(m) , which we term Lys-His tags. In combination with simple acylating agents, they facilitate the acylation of the designated Lys N() -amine under mild conditions and with high selectivity over native Lys residues. .. …
Herein, we report the peptide sequences His(n) -Lys-His(m) , which we term Lys-His tags. In combination with simple acylating agents, …
Initial blood pressure is important for long-term outcome after traumatic spinal cord injury.
Haldrup M, Dyrskog S, Thygesen MM, Kirkegaard H, Kasch H, Rasmussen MM. Haldrup M, et al. Among authors: thygesen mm. J Neurosurg Spine. 2020 Mar 20:1-5. doi: 10.3171/2020.1.SPINE191005. Online ahead of print. J Neurosurg Spine. 2020. PMID: 32197239
To this end, the authors evaluated whether mean arterial blood pressure (MABP) during the prehospital and initial hospital phases of TSCI treatment is correlated with long-term neurological outcome. METHODS: The authors performed a retrospective cohort study based on a cha …
To this end, the authors evaluated whether mean arterial blood pressure (MABP) during the prehospital and initial hospital phases of TSCI tr …
Early breastfeeding problems: A mixed method study of mothers' experiences.
Feenstra MM, Jørgine Kirkeby M, Thygesen M, Danbjørg DB, Kronborg H. Feenstra MM, et al. Among authors: thygesen m. Sex Reprod Healthc. 2018 Jun;16:167-174. doi: 10.1016/j.srhc.2018.04.003. Epub 2018 Apr 6. Sex Reprod Healthc. 2018. PMID: 29804762
METHODS: In a cross-sectional study, a mixed method approach was used to analyse postal survey data from 1437 mothers with full term singleton infants. Content analysis was used to analyse mothers' open text descriptions of their most challenging breastfeeding problem. ...
METHODS: In a cross-sectional study, a mixed method approach was used to analyse postal survey data from 1437 mothers with full term …
Nitrate in drinking water and colorectal cancer risk: A nationwide population-based cohort study.
Schullehner J, Hansen B, Thygesen M, Pedersen CB, Sigsgaard T. Schullehner J, et al. Among authors: thygesen m. Int J Cancer. 2018 Jul 1;143(1):73-79. doi: 10.1002/ijc.31306. Epub 2018 Feb 23. Int J Cancer. 2018. PMID: 29435982 Free article.
Epidemiological studies are few and often challenged by their limited ability of estimating long-term exposure on a detailed individual level. We exploited population-based health register data, linked in time and space with longitudinal drinking water quality data, on an …
Epidemiological studies are few and often challenged by their limited ability of estimating long-term exposure on a detailed individu …
Pre- and postnatal nutrition in sheep affects β-cell secretion and hypothalamic control.
Kongsted AH, Husted SV, Thygesen MP, Christensen VG, Blache D, Tolver A, Larsen T, Quistorff B, Nielsen MO. Kongsted AH, et al. Among authors: thygesen mp. J Endocrinol. 2013 Oct 4;219(2):159-71. doi: 10.1530/JOE-13-0099. Print 2013 Nov. J Endocrinol. 2013. PMID: 24096964
We hypothesised that prenatally undernourished individuals (but not postnatally overnourished ones) are adapted to a life with limited food availability, which would be evident under conditions reflecting starvation, stress and short-term abundance of food. In this study, …
We hypothesised that prenatally undernourished individuals (but not postnatally overnourished ones) are adapted to a life with limited food …
Late gestation undernutrition can predispose for visceral adiposity by altering fat distribution patterns and increasing the preference for a high-fat diet in early postnatal life.
Nielsen MO, Kongsted AH, Thygesen MP, Strathe AB, Caddy S, Quistorff B, Jørgensen W, Christensen VG, Husted S, Chwalibog A, Sejrsen K, Purup S, Svalastoga E, McEvoy FJ, Johnsen L. Nielsen MO, et al. Among authors: thygesen mp. Br J Nutr. 2013 Jun;109(11):2098-110. doi: 10.1017/S0007114512004199. Epub 2012 Oct 15. Br J Nutr. 2013. PMID: 23069212
At 6 months of age, half of the lambs (all males and three females) were slaughtered for further examination and the other half (females only) were transferred to a moderate sheep diet until slaughtered at 24 months of age (adulthood). Maternal undernutrition during late gestatio …
At 6 months of age, half of the lambs (all males and three females) were slaughtered for further examination and the other half (females onl …