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Susceptibility of nonhuman primates to carcinogens of human relevance.
Schoeffner DJ, Thorgeirsson UP. Schoeffner DJ, et al. Among authors: thorgeirsson up. In Vivo. 2000 Jan-Feb;14(1):149-56. In Vivo. 2000. PMID: 10757072 Review.
Nonhuman primates are a valuable experimental model for the evaluation of human carcinogenic risk but have not been widely used for various reasons, such as high cost and lack of availability. The present review discusses the findings from a long-term carcinogenesis study …
Nonhuman primates are a valuable experimental model for the evaluation of human carcinogenic risk but have not been widely used for various …
Long-term toxicity and carcinogenicity study of cyclamate in nonhuman primates.
Takayama S, Renwick AG, Johansson SL, Thorgeirsson UP, Tsutsumi M, Dalgard DW, Sieber SM. Takayama S, et al. Among authors: thorgeirsson up. Toxicol Sci. 2000 Jan;53(1):33-9. doi: 10.1093/toxsci/53.1.33. Toxicol Sci. 2000. PMID: 10653518
Twenty-one monkeys (cynomolgus, rhesus, African green) were fed cyclamate (100 mg/kg and 500 mg/kg) in the diet five times per week from a few days after birth and continuing for up to 24 years. Malignant tumors were diagnosed in three 24-year-old cyclamate monkeys; these …
Twenty-one monkeys (cynomolgus, rhesus, African green) were fed cyclamate (100 mg/kg and 500 mg/kg) in the diet five times per week from a f …
Effects of long-term oral administration of DDT on nonhuman primates.
Takayama S, Sieber SM, Dalgard DW, Thorgeirsson UP, Adamson RH. Takayama S, et al. Among authors: thorgeirsson up. J Cancer Res Clin Oncol. 1999;125(3-4):219-25. doi: 10.1007/s004320050266. J Cancer Res Clin Oncol. 1999. PMID: 10235477
Because of reports on tumorigenic activity in different animal species exposed to DDT a decision was made in 1969 to evaluate the long-term effects of DDT on 24 cynomolgus and rhesus monkeys. DDT (20 mg/kg) was given in the diet for 130 months, followed by an observation p …
Because of reports on tumorigenic activity in different animal species exposed to DDT a decision was made in 1969 to evaluate the long-te …
Long-term feeding of sodium saccharin to nonhuman primates: implications for urinary tract cancer.
Takayama S, Sieber SM, Adamson RH, Thorgeirsson UP, Dalgard DW, Arnold LL, Cano M, Eklund S, Cohen SM. Takayama S, et al. Among authors: thorgeirsson up. J Natl Cancer Inst. 1998 Jan 7;90(1):19-25. doi: 10.1093/jnci/90.1.19. J Natl Cancer Inst. 1998. PMID: 9428778
Numerous epidemiologic studies have not shown any evidence of increased urothelial proliferation associated with ingestion of sodium saccharin. PURPOSE: Our purpose was to determine the effects of long-term feeding of sodium saccharin to three species of nonhuman primates. …
Numerous epidemiologic studies have not shown any evidence of increased urothelial proliferation associated with ingestion of sodium sacchar …
Tumor incidence in a chemical carcinogenesis study of nonhuman primates.
Thorgeirsson UP, Dalgard DW, Reeves J, Adamson RH. Thorgeirsson UP, et al. Regul Toxicol Pharmacol. 1994 Apr;19(2):130-51. doi: 10.1006/rtph.1994.1013. Regul Toxicol Pharmacol. 1994. PMID: 8041912
A large number of substances including a variety of food additives, food components, environmental contaminants, N-nitroso compounds, "classical" rodent carcinogens, antineoplastic agents, and immunosuppressive agents have been evaluated for long-term carcinogenic activity …
A large number of substances including a variety of food additives, food components, environmental contaminants, N-nitroso compounds, "class …