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The Effects of Peri-Operative Adverse Events on Clinical and Patient-Reported Outcomes After Surgery for Degenerative Cervical Myelopathy: An Observational Cohort Study from the Canadian Spine Outcomes and Research Network.
Malhotra AK, Evaniew N, Dea N, Fisher CG, Street JT, Cadotte DW, Jacobs WB, Thomas KC, Attabib N, Manson N, Hall H, Bailey CS, Nataraj A, Phan P, Rampersaud YR, Paquet J, Weber MH, Christie SD, McIntosh G, Wilson JR. Malhotra AK, et al. Among authors: thomas kc. Neurosurgery. 2024 Mar 11. doi: 10.1227/neu.0000000000002896. Online ahead of print. Neurosurgery. 2024. PMID: 38465953
BACKGROUND AND OBJECTIVES: There is a lack of data examining the effects of perioperative adverse events (AEs) on long-term outcomes for patients undergoing surgery for degenerative cervical myelopathy. ...
BACKGROUND AND OBJECTIVES: There is a lack of data examining the effects of perioperative adverse events (AEs) on long-term outcomes …
Neuronal and Astrocyte Insulin-like Growth Factor-1 Signaling Differentially Modulates Ischemic Stroke Damage.
Hayes CA, Morgan NI, Thomas KC, Pushie MJ, Vijayasankar A, Ashmore BG, Wontor K, De Leon MA, Ashpole NM. Hayes CA, et al. Among authors: thomas kc. bioRxiv [Preprint]. 2023 Apr 2:2023.04.02.535245. doi: 10.1101/2023.04.02.535245. bioRxiv. 2023. PMID: 37034764 Free PMC article. Preprint.
Ischemic stroke is a leading cause of death and disability, as therapeutic options for mitigating the long-term deficits precipitated by the event remain limited. Acute administration of the neuroendocrine modulator insulin-like growth factor-1 (IGF-1) attenuates ischemic …
Ischemic stroke is a leading cause of death and disability, as therapeutic options for mitigating the long-term deficits precipitated …
High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice.
Burchfield JG, Kebede MA, Meoli CC, Stöckli J, Whitworth PT, Wright AL, Hoffman NJ, Minard AY, Ma X, Krycer JR, Nelson ME, Tan SX, Yau B, Thomas KC, Wee NKY, Khor EC, Enriquez RF, Vissel B, Biden TJ, Baldock PA, Hoehn KL, Cantley J, Cooney GJ, James DE, Fazakerley DJ. Burchfield JG, et al. Among authors: thomas kc. J Biol Chem. 2018 Apr 13;293(15):5731-5745. doi: 10.1074/jbc.RA117.000808. Epub 2018 Feb 13. J Biol Chem. 2018. PMID: 29440390 Free PMC article.
Prolonged exposure to HFHSD resulted in morbid obesity, ectopic triglyceride deposition in liver and muscle, extensive bone loss, sarcopenia, hyperinsulinemia, and impaired short-term memory. Although many of these defects are typically associated with aging, HFHSD did not …
Prolonged exposure to HFHSD resulted in morbid obesity, ectopic triglyceride deposition in liver and muscle, extensive bone loss, sarcopenia …
Patient-Centered Values and Experiences with Emergency Department and Mental Health Crisis Care.
Thomas KC, Owino H, Ansari S, Adams L, Cyr JM, Gaynes BN, Glickman SW. Thomas KC, et al. Adm Policy Ment Health. 2018 Jul;45(4):611-622. doi: 10.1007/s10488-018-0849-y. Adm Policy Ment Health. 2018. PMID: 29383464 Free PMC article.
Participants preferred the community mental health center. Research should address long-term outcomes to motivate change in psychiatric crisis care....
Participants preferred the community mental health center. Research should address long-term outcomes to motivate change in psychiatr …
The role of the Niemann-Pick disease, type C1 protein in adipocyte insulin action.
Fletcher R, Gribben C, Ma X, Burchfield JG, Thomas KC, Krycer JR, James DE, Fazakerley DJ. Fletcher R, et al. Among authors: thomas kc. PLoS One. 2014 Apr 21;9(4):e95598. doi: 10.1371/journal.pone.0095598. eCollection 2014. PLoS One. 2014. PMID: 24752197 Free PMC article.
This impairment was evident at the level of insulin signalling and insulin-mediated glucose transport in the short term and decreased GLUT4 expression due to reduced liver X receptor (LXR) transcriptional activity in the long-term. ...
This impairment was evident at the level of insulin signalling and insulin-mediated glucose transport in the short term and decreased …
Orthosis versus no orthosis for the treatment of thoracolumbar burst fractures without neurologic injury: a multicenter prospective randomized equivalence trial.
Bailey CS, Urquhart JC, Dvorak MF, Nadeau M, Boyd MC, Thomas KC, Kwon BK, Gurr KR, Bailey SI, Fisher CG. Bailey CS, et al. Among authors: thomas kc. Spine J. 2014 Nov 1;14(11):2557-64. doi: 10.1016/j.spinee.2013.10.017. Epub 2013 Oct 31. Spine J. 2014. PMID: 24184649 Clinical Trial.
CONCLUSIONS: Treating these fractures using early ambulation without a brace avoids the cost and patient deconditioning associated with a brace and complications and costs associated with long-term bed rest if a TLSO or body cast is not available....
CONCLUSIONS: Treating these fractures using early ambulation without a brace avoids the cost and patient deconditioning associated with a br …
The secret "spice": an undetectable toxic cause of seizure.
de Havenon A, Chin B, Thomas KC, Afra P. de Havenon A, et al. Among authors: thomas kc. Neurohospitalist. 2011 Oct;1(4):182-6. doi: 10.1177/1941874411417977. Neurohospitalist. 2011. PMID: 23983854 Free PMC article.
An important aspect of this evaluation is a detailed history which can identify a provoked seizure secondary to drug toxicity and hence avoid unnecessary treatment with antiepileptic drugs. "Spice" is an umbrella term for a variety of synthetic cannabinoid products whose i …
An important aspect of this evaluation is a detailed history which can identify a provoked seizure secondary to drug toxicity and hence avoi …
Minimally invasive versus open approach for cervical laminoforaminotomy.
Winder MJ, Thomas KC. Winder MJ, et al. Among authors: thomas kc. Can J Neurol Sci. 2011 Mar;38(2):262-7. doi: 10.1017/s0317167100011446. Can J Neurol Sci. 2011. PMID: 21320831
Patient demographics, intra-operative parameters, length of hospitalization, post-operative analgesic use, complications and short-term neurological outcome were compared between groups. RESULTS: Between 1999 and 2009, a total of 107 patients were identified to have underg …
Patient demographics, intra-operative parameters, length of hospitalization, post-operative analgesic use, complications and short-term …
Comparison of thoracolumbosacral orthosis and no orthosis for the treatment of thoracolumbar burst fractures: interim analysis of a multicenter randomized clinical equivalence trial.
Bailey CS, Dvorak MF, Thomas KC, Boyd MC, Paquett S, Kwon BK, France J, Gurr KR, Bailey SI, Fisher CG. Bailey CS, et al. Among authors: thomas kc. J Neurosurg Spine. 2009 Sep;11(3):295-303. doi: 10.3171/2009.3.SPINE08312. J Neurosurg Spine. 2009. PMID: 19769510 Clinical Trial.
The influence of a brace on early pain control and function and on long-term 1- and 2-year outcomes remains to be determined. However, the authors contend that a thoracolumbar burst fracture, in exclusion of an associated posterior ligamentous complex injury, is inherently …
The influence of a brace on early pain control and function and on long-term 1- and 2-year outcomes remains to be determined. However …
Minority Response to Health Insurance Coverage for Mental Health Services.
Thomas KC, Snowden LR. Thomas KC, et al. J Ment Health Policy Econ. 2001 Mar 1;4(1):35-41. J Ment Health Policy Econ. 2001. PMID: 11967464
METHODS: The analysis uses data from the 1987 National Medical Expenditure Survey to model mental health expenditures as a function of minority status and private insurance coverage. An interaction term between the two highlights any differences in response to private and …
METHODS: The analysis uses data from the 1987 National Medical Expenditure Survey to model mental health expenditures as a function of minor …