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Impacts of metal mining on river systems: a global assessment.
Macklin MG, Thomas CJ, Mudbhatkal A, Brewer PA, Hudson-Edwards KA, Lewin J, Scussolini P, Eilander D, Lechner A, Owen J, Bird G, Kemp D, Mangalaa KR. Macklin MG, et al. Among authors: thomas cj. Science. 2023 Sep 22;381(6664):1345-1350. doi: 10.1126/science.adg6704. Epub 2023 Sep 21. Science. 2023. PMID: 37733841
The number of people exposed to contamination sourced from long-term discharge of mining waste into rivers is almost 50 times greater than the number directly affected by tailings dam failures....
The number of people exposed to contamination sourced from long-term discharge of mining waste into rivers is almost 50 times greater …
A comparison of the pharmacokinetics and NMDAR antagonism-associated neurotoxicity of ketamine, (2R,6R)-hydroxynorketamine and MK-801.
Morris PJ, Burke RD, Sharma AK, Lynch DC, Lemke-Boutcher LE, Mathew S, Elayan I, Rao DB, Gould TD, Zarate CA Jr, Zanos P, Moaddel R, Thomas CJ. Morris PJ, et al. Among authors: thomas cj. Neurotoxicol Teratol. 2021 Sep-Oct;87:106993. doi: 10.1016/j.ntt.2021.106993. Epub 2021 May 1. Neurotoxicol Teratol. 2021. PMID: 33945878 Free PMC article.
With the increasing use of ketamine as an off-label treatment for depression and the recent FDA approval of (S)-ketamine for treatment-resistant depression, there is an increased need to understand the long-term safety profile of chronic ketamine administration. Of particu …
With the increasing use of ketamine as an off-label treatment for depression and the recent FDA approval of (S)-ketamine for treatment-resis …
Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms.
Zanos P, Moaddel R, Morris PJ, Riggs LM, Highland JN, Georgiou P, Pereira EFR, Albuquerque EX, Thomas CJ, Zarate CA Jr, Gould TD. Zanos P, et al. Among authors: thomas cj. Pharmacol Rev. 2018 Jul;70(3):621-660. doi: 10.1124/pr.117.015198. Pharmacol Rev. 2018. PMID: 29945898 Free PMC article. Review.
Dissociative, psychotomimetic, cognitive, and peripheral side effects associated with short-term or prolonged exposure, as well as recreational ketamine use, are also discussed. ...
Dissociative, psychotomimetic, cognitive, and peripheral side effects associated with short-term or prolonged exposure, as well as re …
Improvement in dietary inflammatory index score after 6-month dietary intervention is associated with reduction in interleukin-6 in patients with coronary heart disease: The AUSMED heart trial.
Mayr HL, Itsiopoulos C, Tierney AC, Ruiz-Canela M, Hebert JR, Shivappa N, Thomas CJ. Mayr HL, et al. Among authors: thomas cj. Nutr Res. 2018 Jul;55:108-121. doi: 10.1016/j.nutres.2018.04.007. Epub 2018 Apr 25. Nutr Res. 2018. PMID: 29807669 Clinical Trial.
Future research is warranted to investigate the impact of change in DII on cardiometabolic risk markers in larger cohorts, other disease populations or healthy subjects and with longer-term follow up....
Future research is warranted to investigate the impact of change in DII on cardiometabolic risk markers in larger cohorts, other disease pop …
Endogenous Annexin-A1 Regulates Haematopoietic Stem Cell Mobilisation and Inflammatory Response Post Myocardial Infarction in Mice In Vivo.
Qin CX, Finlayson SB, Al-Sharea A, Tate M, De Blasio MJ, Deo M, Rosli S, Prakoso D, Thomas CJ, Kiriazis H, Gould E, Yang YH, Morand EF, Perretti M, Murphy AJ, Du XJ, Gao XM, Ritchie RH. Qin CX, et al. Among authors: thomas cj. Sci Rep. 2017 Nov 30;7(1):16615. doi: 10.1038/s41598-017-16317-1. Sci Rep. 2017. PMID: 29192208 Free PMC article.
Endogenous anti-inflammatory annexin-A1 (ANX-A1) plays an important role in preserving left ventricular (LV) viability and function after ischaemic insults in vitro, but its long-term cardioprotective actions in vivo are largely unknown. We tested the hypothesis that ANX-A …
Endogenous anti-inflammatory annexin-A1 (ANX-A1) plays an important role in preserving left ventricular (LV) viability and function after is …
Effects of local irradiation combined with sunitinib on early remodeling, mitochondria, and oxidative stress in the rat heart.
Sridharan V, Thomas CJ, Cao M, Melnyk SB, Pavliv O, Joseph J, Singh SP, Sharma S, Moros EG, Boerma M. Sridharan V, et al. Among authors: thomas cj. Radiother Oncol. 2016 May;119(2):259-64. doi: 10.1016/j.radonc.2016.03.027. Epub 2016 Apr 9. Radiother Oncol. 2016. PMID: 27072940 Free PMC article.
CONCLUSIONS: This study found no early enhanced effects of radiation and sunitinib on cardiac function or structure. Long-term effects remain to be determined....
CONCLUSIONS: This study found no early enhanced effects of radiation and sunitinib on cardiac function or structure. Long-term effect …
Aurora B kinase is a potent and selective target in MYCN-driven neuroblastoma.
Bogen D, Wei JS, Azorsa DO, Ormanoglu P, Buehler E, Guha R, Keller JM, Mathews Griner LA, Ferrer M, Song YK, Liao H, Mendoza A, Gryder BE, Sindri S, He J, Wen X, Zhang S, Shern JF, Yohe ME, Taschner-Mandl S, Shohet JM, Thomas CJ, Martin SE, Ambros PF, Khan J. Bogen D, et al. Among authors: thomas cj. Oncotarget. 2015 Nov 3;6(34):35247-62. doi: 10.18632/oncotarget.6208. Oncotarget. 2015. PMID: 26497213 Free PMC article.
Despite advances in multimodal treatment, neuroblastoma (NB) is often fatal for children with high-risk disease and many survivors need to cope with long-term side effects from high-dose chemotherapy and radiation. To identify new therapeutic targets, we performed an siRNA …
Despite advances in multimodal treatment, neuroblastoma (NB) is often fatal for children with high-risk disease and many survivors need to c …
Omega-3 Fatty Acids in Early Prevention of Inflammatory Neurodegenerative Disease: A Focus on Alzheimer's Disease.
Thomas J, Thomas CJ, Radcliffe J, Itsiopoulos C. Thomas J, et al. Among authors: thomas cj. Biomed Res Int. 2015;2015:172801. doi: 10.1155/2015/172801. Epub 2015 Aug 2. Biomed Res Int. 2015. PMID: 26301243 Free PMC article. Review.
This review specifically focusses on the evidence in humans from epidemiological, dietary intervention, and supplementation studies, which supports the role of long chain omega-3 fatty acids in the prevention or delay of cognitive decline in AD in its early stages. Longer term …
This review specifically focusses on the evidence in humans from epidemiological, dietary intervention, and supplementation studies, which s …
Lymph node ratio predicts recurrence and survival after R0 resection for non-small cell lung cancer.
Taylor MD, LaPar DJ, Thomas CJ, Persinger M, Stelow EB, Kozower BD, Lau CL, Jones DR. Taylor MD, et al. Among authors: thomas cj. Ann Thorac Surg. 2013 Oct;96(4):1163-1170. doi: 10.1016/j.athoracsur.2013.04.031. Epub 2013 Aug 30. Ann Thorac Surg. 2013. PMID: 23998409
METHODS: A total of 1,143 consecutive patients underwent R0 resection for NSCLC between 1999 and 2008 at a high-volume single institution with 26% (n = 302) having N1 and N2 disease. The primary endpoints of the study were long-term survival and recurrence as a function of …
METHODS: A total of 1,143 consecutive patients underwent R0 resection for NSCLC between 1999 and 2008 at a high-volume single institution wi …
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