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Management and outcomes of pregnant women admitted to intensive care unit for severe pneumonia related to SARS-CoV-2 infection: the multicenter and international COVIDPREG study.
Péju E, Belicard F, Silva S, Hraiech S, Painvin B, Kamel T, Thille AW, Goury A, Grimaldi D, Jung B, Piagnerelli M, Winiszewski H, Jourdain M, Jozwiak M; COVIDPREG Study Group. Péju E, et al. Among authors: thille aw. Intensive Care Med. 2022 Sep;48(9):1185-1196. doi: 10.1007/s00134-022-06833-8. Epub 2022 Aug 17. Intensive Care Med. 2022. PMID: 35978137 Free PMC article.
In multivariate analysis, risk factors for intubation were obesity (cause-specific hazard ratio (CSH) 2.00, 95% CI (1.05-3.80), p = 0.03), term of pregnancy (CSH 1.07, 95% CI (1.02-1.10), per + 1 week gestation, p = 0.01), extent of computed tomography (CT) scan abnormalit …
In multivariate analysis, risk factors for intubation were obesity (cause-specific hazard ratio (CSH) 2.00, 95% CI (1.05-3.80), p = 0.03), …
Noninvasive respiratory support following extubation in critically ill adults: a systematic review and network meta-analysis.
Fernando SM, Tran A, Sadeghirad B, Burns KEA, Fan E, Brodie D, Munshi L, Goligher EC, Cook DJ, Fowler RA, Herridge MS, Cardinal P, Jaber S, Møller MH, Thille AW, Ferguson ND, Slutsky AS, Brochard LJ, Seely AJE, Rochwerg B. Fernando SM, et al. Among authors: thille aw. Intensive Care Med. 2022 Feb;48(2):137-147. doi: 10.1007/s00134-021-06581-1. Epub 2021 Nov 25. Intensive Care Med. 2022. PMID: 34825256 Free article.
Compared to conventional oxygen therapy, neither NIPPV (OR 0.8 [95% CI 0.61-1.04], moderate certainty) or HFNC (OR 0.9 [95% CI 0.66-1.24], low certainty) reduced short-term mortality. Consistent findings were demonstrated across multiple subgroups, including high- and low- …
Compared to conventional oxygen therapy, neither NIPPV (OR 0.8 [95% CI 0.61-1.04], moderate certainty) or HFNC (OR 0.9 [95% CI 0.66-1.24], l …
The central nervous system during lung injury and mechanical ventilation: a narrative review.
Albaiceta GM, Brochard L, Dos Santos CC, Fernández R, Georgopoulos D, Girard T, Jubran A, López-Aguilar J, Mancebo J, Pelosi P, Skrobik Y, Thille AW, Wilcox ME, Blanch L. Albaiceta GM, et al. Among authors: thille aw. Br J Anaesth. 2021 Oct;127(4):648-659. doi: 10.1016/j.bja.2021.05.038. Epub 2021 Jul 31. Br J Anaesth. 2021. PMID: 34340836 Free article. Review.
Further, it proposes directions for future research ranging from identifying mechanisms of multiorgan failure to mitigating long-term sequelae after critical illness....
Further, it proposes directions for future research ranging from identifying mechanisms of multiorgan failure to mitigating long-term …
Sedation practice and discomfort during withdrawal of mechanical ventilation in critically ill patients at end-of-life: a post-hoc analysis of a multicenter study.
Robert R, Le Gouge A, Kentish-Barnes N, Adda M, Audibert J, Barbier F, Bourcier S, Bourenne J, Boyer A, Devaquet J, Grillet G, Guisset O, Hyacinthe AC, Jourdain M, Lerolle N, Lesieur O, Mercier E, Messika J, Renault A, Vinatier I, Azoulay E, Thille AW, Reignier J; group SEDARREVE. Robert R, et al. Among authors: thille aw. Intensive Care Med. 2020 Jun;46(6):1194-1203. doi: 10.1007/s00134-020-05930-w. Epub 2020 Jan 29. Intensive Care Med. 2020. PMID: 31996960
After multivariate logistic regression, extubation (as compared terminal weaning) was the only factor associated with discomfort, whereas deep sedation and administration of vasoactive drugs were two factors independently associated with no discomfort. Long-term evaluation …
After multivariate logistic regression, extubation (as compared terminal weaning) was the only factor associated with discomfort, whereas de …
Admission of tetanus patients to the ICU: a retrospective multicentre study.
Mahieu R, Reydel T, Maamar A, Tadié JM, Jamet A, Thille AW, Chudeau N, Huntzinger J, Grangé S, Beduneau G, Courte A, Ehrmann S, Lemarié J, Gibot S, Darmon M, Guitton C, Champey J, Schwebel C, Dellamonica J, Wipf T, Meziani F, Du Cheyron D, Kouatchet A, Lerolle N. Mahieu R, et al. Among authors: thille aw. Ann Intensive Care. 2017 Nov 7;7(1):112. doi: 10.1186/s13613-017-0333-y. Ann Intensive Care. 2017. PMID: 29116572 Free PMC article.
BACKGROUND: An extended course of tetanus (up to 6 weeks) requiring ICU admission and protracted mechanical ventilation (MV) may have a significant impact on short- and long-term survival. The subject is noteworthy and deserves to be discussed. ...Despite prolonged MV and …
BACKGROUND: An extended course of tetanus (up to 6 weeks) requiring ICU admission and protracted mechanical ventilation (MV) may have a sign …
Prediction and Outcome of Intensive Care Unit-Acquired Paresis.
Peñuelas O, Muriel A, Frutos-Vivar F, Fan E, Raymondos K, Rios F, Nin N, Thille AW, González M, Villagomez AJ, Davies AR, Du B, Maggiore SM, Matamis D, Abroug F, Moreno RP, Kuiper MA, Anzueto A, Ferguson ND, Esteban A. Peñuelas O, et al. Among authors: thille aw. J Intensive Care Med. 2018 Jan;33(1):16-28. doi: 10.1177/0885066616643529. Epub 2016 Apr 13. J Intensive Care Med. 2018. PMID: 27080128
Our objective was to evaluate predictors for ICUAP and the short-term outcomes associated with this condition. METHODS: A secondary analysis of a prospective study including 4157 mechanically ventilated adults in 494 intensive care units from 39 countries. ...Propensity sc …
Our objective was to evaluate predictors for ICUAP and the short-term outcomes associated with this condition. METHODS: A secondary a …
Results of noninvasive ventilation in very old patients.
Schortgen F, Follin A, Piccari L, Roche-Campo F, Carteaux G, Taillandier-Heriche E, Krypciak S, Thille AW, Paillaud E, Brochard L. Schortgen F, et al. Among authors: thille aw. Ann Intensive Care. 2012 Feb 21;2(1):5. doi: 10.1186/2110-5820-2-5. Ann Intensive Care. 2012. PMID: 22353636 Free PMC article.
BACKGROUND: Noninvasive ventilation (NIV) is frequently used for the management of acute respiratory failure (ARF) in very old patients ( 80 years), often in the context of a do-not-intubate order (DNI). We aimed to determine its efficacy and long-term outcome. METHODS: Pr …
BACKGROUND: Noninvasive ventilation (NIV) is frequently used for the management of acute respiratory failure (ARF) in very old patients ( 80 …