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Correction to: Tumor pH and metastasis: a malignant process beyond hypoxia.
Thews O, Riemann A. Thews O, et al. Cancer Metastasis Rev. 2019 Jun;38(1-2):131. doi: 10.1007/s10555-019-09801-9. Cancer Metastasis Rev. 2019. PMID: 31250236
The authors have noticed a typographical error in the published article. The term "epithelial-to-mesenchymal transition" should have been used instead of the term "endothelial-to-mesenchymal transition" throughout the manuscript....
The authors have noticed a typographical error in the published article. The term "epithelial-to-mesenchymal transition" should have …
Tumor pH and metastasis: a malignant process beyond hypoxia.
Thews O, Riemann A. Thews O, et al. Cancer Metastasis Rev. 2019 Jun;38(1-2):113-129. doi: 10.1007/s10555-018-09777-y. Cancer Metastasis Rev. 2019. PMID: 30607627 Review.
Several studies indicate that acidosis induces (independently from hypoxia) hematogenous and lymphatic spread of tumor cells worsening the long-term prognosis of tumor patients. This review gives an overview on the impact of low pH on different steps of metastasis includin …
Several studies indicate that acidosis induces (independently from hypoxia) hematogenous and lymphatic spread of tumor cells worsening the l …
Long-term biodistribution study of HPMA-ran-LMA copolymers in vivo by means of (131)I-labeling.
Wagener K, Moderegger D, Allmeroth M, Reibel A, Kramer S, Biesalski B, Bausbacher N, Zentel R, Thews O, Rösch F. Wagener K, et al. Among authors: thews o. Nucl Med Biol. 2018 Mar;58:59-66. doi: 10.1016/j.nucmedbio.2017.12.002. Epub 2017 Dec 16. Nucl Med Biol. 2018. PMID: 29413458
BACKGROUND: For the evaluation of macromolecular drug delivery systems suitable pre-clinical monitoring of potential nanocarrier systems is needed. In this regard, both short-term as well as long-term in vivo tracking is crucial to understand structure-property rela …
BACKGROUND: For the evaluation of macromolecular drug delivery systems suitable pre-clinical monitoring of potential nanocarrier systems is …
Acidic priming enhances metastatic potential of cancer cells.
Riemann A, Schneider B, Gündel D, Stock C, Thews O, Gekle M. Riemann A, et al. Among authors: thews o. Pflugers Arch. 2014 Nov;466(11):2127-38. doi: 10.1007/s00424-014-1458-6. Epub 2014 Feb 16. Pflugers Arch. 2014. PMID: 24531759
When the tumor cells were transferred back to pH 7.4, enhanced motility persisted for at least 3 h but vanished after longer periods (24 h), therefore presenting a "short-term memory effect." Although acidosis augmented phosphorylation of ERK1/2 and p38, and inhibition of …
When the tumor cells were transferred back to pH 7.4, enhanced motility persisted for at least 3 h but vanished after longer periods (24 h), …
Assessing p-glycoprotein (Pgp) activity in vivo utilizing 68Ga-Schiff base complexes.
Fellner M, Dillenburg W, Buchholz HG, Bausbacher N, Schreckenberger M, Renz F, Rösch F, Thews O. Fellner M, et al. Among authors: thews o. Mol Imaging Biol. 2011 Oct;13(5):985-94. doi: 10.1007/s11307-010-0410-1. Mol Imaging Biol. 2011. PMID: 20824508
CONCLUSIONS: Two (68)Ga-labeled ligands appear to be valuable for imaging non-invasively the intratumoral Pgp activity. On a long term, patients with multidrug-resistant tumors pre-therapeutically may be identified prior to treatment....
CONCLUSIONS: Two (68)Ga-labeled ligands appear to be valuable for imaging non-invasively the intratumoral Pgp activity. On a long term …
An in vivo tumor model expressing green fluorescent protein for the investigation of metastasis.
Thews O, Lambert C, Kelleher DK, Biesalski HK, Vaupel P, Frank J. Thews O, et al. Int J Oncol. 2005 Sep;27(3):705-12. Int J Oncol. 2005. PMID: 16077920
Cell sorting, however, did not enable selection of a DSGFP cell population with a higher long-term stable GFP expression. After i.p. cell implantation, GFP expression in DSGFP ascites cells was maintained over at least 19 passages. ...
Cell sorting, however, did not enable selection of a DSGFP cell population with a higher long-term stable GFP expression. After i.p. …
Microenvironmental adaptation of experimental tumours to chronic vs acute hypoxia.
Thews O, Wolloscheck T, Dillenburg W, Kraus S, Kelleher DK, Konerding MA, Vaupel P. Thews O, et al. Br J Cancer. 2004 Sep 13;91(6):1181-9. doi: 10.1038/sj.bjc.6602066. Br J Cancer. 2004. PMID: 15305198 Free PMC article.
This study investigated long-term microenvironmental responses (oxygenation, perfusion, metabolic status, proliferation, vascular endothelial growth factor (VEGF) expression and vascularisation) to chronic hypoxia in experimental tumours. ...In the chronically hypoxic anim …
This study investigated long-term microenvironmental responses (oxygenation, perfusion, metabolic status, proliferation, vascular end …
Treatment resistance of solid tumors: role of hypoxia and anemia.
Vaupel P, Thews O, Hoeckel M. Vaupel P, et al. Among authors: thews o. Med Oncol. 2001;18(4):243-59. doi: 10.1385/MO:18:4:243. Med Oncol. 2001. PMID: 11918451 Review.
These, in turn, can drive subsequent events that are known to further increase resistance to therapy (in addition to critically affecting long-term prognosis). Treatment resistance in anemic patients can be, at least partially, prevented or overcome by anemia correction, r …
These, in turn, can drive subsequent events that are known to further increase resistance to therapy (in addition to critically affecting lo …