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Single-Cell RNA Sequencing Reveals Repair Features of Human Umbilical Cord Mesenchymal Stromal Cells.
Cyr-Depauw C, Cook DP, Mižik I, Lesage F, Vadivel A, Renesme L, Deng Y, Zhong S, Bardin P, Xu L, Möbius MA, Marzahn J, Freund D, Stewart DJ, Vanderhyden BC, Rüdiger M, Thébaud B. Cyr-Depauw C, et al. Among authors: thebaud b. Am J Respir Crit Care Med. 2024 Apr 2. doi: 10.1164/rccm.202310-1975OC. Online ahead of print. Am J Respir Crit Care Med. 2024. PMID: 38564376
BPD results in impaired lung alveolar and vascular development and long-term respiratory morbidity, for which only supportive therapies exist. ...OBJECTIVES: To determine and correlate single-cell UC-MSC transcriptomic profile with therapeutic potential. METHODS: UC-MSCs f …
BPD results in impaired lung alveolar and vascular development and long-term respiratory morbidity, for which only supportive therapi …
Prophylactic Administration of Mesenchymal Stromal Cells Does Not Prevent Arrested Lung Development in Extremely Premature-Born Non-Human Primates.
Möbius MA, Seidner SR, McCurnin DC, Menschner L, Fürböter-Behnert I, Schönfeld J, Marzahn J, Freund D, Münch N, Hering S, Mustafa SB, Anzueto DG, Winter LA, Blanco CL, Hanes MA, Rüdiger M, Thébaud B. Möbius MA, et al. Among authors: thebaud b. Stem Cells Transl Med. 2023 Mar 3;12(2):97-111. doi: 10.1093/stcltm/szac088. Stem Cells Transl Med. 2023. PMID: 36724000 Free PMC article.
Premature birth is a leading cause of childhood morbidity and mortality and often followed by an arrest of postnatal lung development called bronchopulmonary dysplasia. ...We concluded that a single, intravenous administration of MSC had no short- to mid-term lung-p …
Premature birth is a leading cause of childhood morbidity and mortality and often followed by an arrest of postnatal lung development …
Landscape analysis for a neonatal disease progression model of bronchopulmonary dysplasia: Leveraging clinical trial experience and real-world data.
Barrett JS, Cala Pane M, Knab T, Roddy W, Beusmans J, Jordie E, Singh K, Davis JM, Romero K, Padula M, Thebaud B, Turner M. Barrett JS, et al. Among authors: thebaud b. Front Pharmacol. 2022 Oct 12;13:988974. doi: 10.3389/fphar.2022.988974. eCollection 2022. Front Pharmacol. 2022. PMID: 36313352 Free PMC article.
It will be important to determine if: 1) a large, multisource aggregation of real-world data (RWD) will allow identification of validated risk factors and surrogate endpoints for BPD, and 2) the inclusion of these simulations will identify risk factors and surrogate endpoints for …
It will be important to determine if: 1) a large, multisource aggregation of real-world data (RWD) will allow identification of validated ri …
Neonatal hyperoxia in mice triggers long-term cognitive deficits via impairments in cerebrovascular function and neurogenesis.
Lithopoulos MA, Toussay X, Zhong S, Xu L, Mustafa SB, Ouellette J, Freitas-Andrade M, Comin CH, Bassam HA, Baker AN, Sun Y, Wakem M, Moreira AG, Blanco CL, Vadivel A, Tsilfidis C, Seidner SR, Slack RS, Lagace DC, Wang J, Lacoste B, Thébaud B. Lithopoulos MA, et al. Among authors: thebaud b. J Clin Invest. 2022 Nov 15;132(22):e146095. doi: 10.1172/JCI146095. J Clin Invest. 2022. PMID: 36136598 Free PMC article.
Preterm birth is the leading cause of death in children under 5 years of age. ...
Preterm birth is the leading cause of death in children under 5 years of age. ...
The comprehensive transcriptome of human ductus arteriosus smooth muscle cells (hDASMC).
Bentley RET, Hindmarch CCT, Dunham-Snary KJ, Snetsinger B, Mewburn JD, Thébaud A, Lima PDA, Thébaud B, Archer SL. Bentley RET, et al. Among authors: thebaud b. Data Brief. 2021 Dec 20;40:107736. doi: 10.1016/j.dib.2021.107736. eCollection 2022 Feb. Data Brief. 2021. PMID: 35005134 Free PMC article.
Here, we study human DA smooth muscle cells (DASMC) taken from 10 term infants during congenital heart surgery. Purification of these cells using flow cytometry ensured a pure population of DASMCs, which we confirmed as responsive to O(2). ...
Here, we study human DA smooth muscle cells (DASMC) taken from 10 term infants during congenital heart surgery. Purification of these …
The molecular mechanisms of oxygen-sensing in human ductus arteriosus smooth muscle cells: A comprehensive transcriptome profile reveals a central role for mitochondria.
Bentley RET, Hindmarch CCT, Dunham-Snary KJ, Snetsinger B, Mewburn JD, Thébaud A, Lima PDA, Thébaud B, Archer SL. Bentley RET, et al. Among authors: thebaud b. Genomics. 2021 Sep;113(5):3128-3140. doi: 10.1016/j.ygeno.2021.07.006. Epub 2021 Jul 8. Genomics. 2021. PMID: 34245829 Free PMC article.
Failure of DA closure results in persistent patent ductus arteriosus (PDA), a common complication of extreme preterm birth. The DA's response to O(2), though modulated by the endothelium, is intrinsic to the DA smooth muscle cells (DASMC). ...To date, there has not been an …
Failure of DA closure results in persistent patent ductus arteriosus (PDA), a common complication of extreme preterm birth. The DA's …
Stem cell-based interventions for the prevention of morbidity and mortality following hypoxic-ischaemic encephalopathy in newborn infants.
Bruschettini M, Romantsik O, Moreira A, Ley D, Thébaud B. Bruschettini M, et al. Among authors: thebaud b. Cochrane Database Syst Rev. 2020 Aug 19;8(8):CD013202. doi: 10.1002/14651858.CD013202.pub2. Cochrane Database Syst Rev. 2020. PMID: 32813884 Free PMC article.
BACKGROUND: Hypoxic-ischaemic encephalopathy (HIE) is a leading cause of mortality and long-term neurological sequelae, affecting thousands of children worldwide. ...DATA COLLECTION AND ANALYSIS: For each of the included trials, two authors independently planned to extract …
BACKGROUND: Hypoxic-ischaemic encephalopathy (HIE) is a leading cause of mortality and long-term neurological sequelae, affecting tho …
Characterization of the innate immune response in a novel murine model mimicking bronchopulmonary dysplasia.
Cyr-Depauw C, Hurskainen M, Vadivel A, Mižíková I, Lesage F, Thébaud B. Cyr-Depauw C, et al. Among authors: thebaud b. Pediatr Res. 2021 Mar;89(4):803-813. doi: 10.1038/s41390-020-0967-6. Epub 2020 May 20. Pediatr Res. 2021. PMID: 32434214
Simultaneously, a Siglec-F intermediate macrophage population emerged. CONCLUSION: This study provides long-term analysis of the 2HIT model, suggesting impairment of type 2 cytokine environment and altered alveolar macrophage profile in the lung. ...
Simultaneously, a Siglec-F intermediate macrophage population emerged. CONCLUSION: This study provides long-term analysis of the 2HIT …
Lifetime patient outcomes and healthcare utilization for Bronchopulmonary dysplasia (BPD) and extreme preterm infants: a microsimulation study.
van Katwyk S, Augustine S, Thébaud B, Thavorn K. van Katwyk S, et al. Among authors: thebaud b. BMC Pediatr. 2020 Mar 25;20(1):136. doi: 10.1186/s12887-020-02037-5. BMC Pediatr. 2020. PMID: 32213174 Free PMC article.
There is a general understanding of BPD's significant impact on the short-term outcomes however there is little evidence on long-term outcomes. ...METHODS: We developed a microsimulation model to estimate lifetime clinical and economic burden of BPD among extreme pr …
There is a general understanding of BPD's significant impact on the short-term outcomes however there is little evidence on long-t …
How to introduce MSC-based therapy for the developing lung safely into clinical care?
Rüdiger M, Kirpalani H, Steinhorn R, Davis JM, Thebaud B. Rüdiger M, et al. Among authors: thebaud b. Pediatr Res. 2020 Sep;88(3):365-368. doi: 10.1038/s41390-020-0758-0. Epub 2020 Jan 13. Pediatr Res. 2020. PMID: 31931507 Review.
Extreme prematurity is associated with an increased risk to develop bronchopulmonary dysplasia (BPD). Severe BPD is associated with a significant long-term burden for the affected infant, families and society. Currently there are limited prevention and treatment options. . …
Extreme prematurity is associated with an increased risk to develop bronchopulmonary dysplasia (BPD). Severe BPD is associated with a signif …
39 results