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Programmable antivirals targeting critical conserved viral RNA secondary structures from influenza A virus and SARS-CoV-2.
Hagey RJ, Elazar M, Pham EA, Tian S, Ben-Avi L, Bernardin-Souibgui C, Yee MF, Moreira FR, Rabinovitch MV, Meganck RM, Fram B, Beck A, Gibson SA, Lam G, Devera J, Kladwang W, Nguyen K, Xiong A, Schaffert S, Avisar T, Liu P, Rustagi A, Fichtenbaum CJ, Pang PS, Khatri P, Tseng CT, Taubenberger JK, Blish CA, Hurst BL, Sheahan TP, Das R, Glenn JS. Hagey RJ, et al. Among authors: taubenberger jk. Nat Med. 2022 Sep;28(9):1944-1955. doi: 10.1038/s41591-022-01908-x. Epub 2022 Aug 18. Nat Med. 2022. PMID: 35982307 Free PMC article.
These findings highlight the potential applicability of this approach to any virus of interest via a process we term 'programmable antivirals', with implications for antiviral prophylaxis and post-exposure therapy....
These findings highlight the potential applicability of this approach to any virus of interest via a process we term 'programmable an …
Influenza A Reinfection in Sequential Human Challenge: Implications for Protective Immunity and "Universal" Vaccine Development.
Memoli MJ, Han A, Walters KA, Czajkowski L, Reed S, Athota R, Angela Rosas L, Cervantes-Medina A, Park JK, Morens DM, Kash JC, Taubenberger JK. Memoli MJ, et al. Among authors: taubenberger jk. Clin Infect Dis. 2020 Feb 14;70(5):748-753. doi: 10.1093/cid/ciz281. Clin Infect Dis. 2020. PMID: 30953061 Free PMC article.
Certain assumptions underlie current vaccine developmental strategies, including that infection with a particular influenza A virus should offer long-term or lifelong protection against that strain, preventing reinfection. ...
Certain assumptions underlie current vaccine developmental strategies, including that infection with a particular influenza A virus should o …
Evaluation of Antihemagglutinin and Antineuraminidase Antibodies as Correlates of Protection in an Influenza A/H1N1 Virus Healthy Human Challenge Model.
Memoli MJ, Shaw PA, Han A, Czajkowski L, Reed S, Athota R, Bristol T, Fargis S, Risos K, Powers JH, Davey RT Jr, Taubenberger JK. Memoli MJ, et al. Among authors: taubenberger jk. mBio. 2016 Apr 19;7(2):e00417-16. doi: 10.1128/mBio.00417-16. mBio. 2016. PMID: 27094330 Free PMC article.
Despite long-term investment, influenza continues to be a significant worldwide problem. ...
Despite long-term investment, influenza continues to be a significant worldwide problem. ...
Pandemic influenza: certain uncertainties.
Morens DM, Taubenberger JK. Morens DM, et al. Among authors: taubenberger jk. Rev Med Virol. 2011 Sep;21(5):262-84. doi: 10.1002/rmv.689. Epub 2011 Jun 27. Rev Med Virol. 2011. PMID: 21706672 Free PMC article. Review.
Some are followed by new pandemics, whereas others fade gradually or abruptly into long-term endemicity. Human influenza pandemics have been caused by viruses that evolved singly or in co-circulation with other pandemic virus descendants and often have involved significant …
Some are followed by new pandemics, whereas others fade gradually or abruptly into long-term endemicity. Human influenza pandemics ha …
Stochastic processes are key determinants of short-term evolution in influenza a virus.
Nelson MI, Simonsen L, Viboud C, Miller MA, Taylor J, George KS, Griesemer SB, Ghedin E, Sengamalay NA, Spiro DJ, Volkov I, Grenfell BT, Lipman DJ, Taubenberger JK, Holmes EC. Nelson MI, et al. Among authors: taubenberger jk. PLoS Pathog. 2006 Dec;2(12):e125. doi: 10.1371/journal.ppat.0020125. PLoS Pathog. 2006. PMID: 17140286 Free PMC article.
These results indicate that adaptive evolution occurs only sporadically in influenza A virus; rather, the stochastic processes of viral migration and clade reassortment play a vital role in shaping short-term evolutionary dynamics. Thus, predicting future patterns of influ …
These results indicate that adaptive evolution occurs only sporadically in influenza A virus; rather, the stochastic processes of viral migr …
Loss of heterozygosity on chromosome 11p15 during histological progression in microdissected ductal carcinoma of the breast.
Lichy JH, Zavar M, Tsai MM, O'Leary TJ, Taubenberger JK. Lichy JH, et al. Among authors: taubenberger jk. Am J Pathol. 1998 Jul;153(1):271-8. doi: 10.1016/S0002-9440(10)65568-X. Am J Pathol. 1998. PMID: 9665488 Free PMC article.
LOH at 11p15.5 showed no correlation with estrogen receptor status, the presence of positive lymph nodes, tumor size, histological grade, or long-term survival. We conclude that 11p15 LOH usually occurs early in breast cancer development but less frequently does not develo …
LOH at 11p15.5 showed no correlation with estrogen receptor status, the presence of positive lymph nodes, tumor size, histological grade, or …