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Plasma concentrations of inhaled corticosteroids in relation to airflow obstruction in asthma.
Mortimer KJ, Harrison TW, Tang Y, Wu K, Lewis S, Sahasranaman S, Hochhaus G, Tattersfield AE. Mortimer KJ, et al. Among authors: tattersfield ae. Br J Clin Pharmacol. 2006 Oct;62(4):412-9. doi: 10.1111/j.1365-2125.2006.02712.x. Br J Clin Pharmacol. 2006. PMID: 16995862 Free PMC article. Clinical Trial.
CONCLUSION: The higher plasma concentrations of inhaled corticosteroids in patients with a higher FEV(1)% predicted suggests that, for any given dose, these patients will be at greater risk of developing adverse systemic effects with long-term use....
CONCLUSION: The higher plasma concentrations of inhaled corticosteroids in patients with a higher FEV(1)% predicted suggests that, for any g …
Safety of inhaled corticosteroids.
Tattersfield AE, Harrison TW, Hubbard RB, Mortimer K. Tattersfield AE, et al. Proc Am Thorac Soc. 2004;1(3):171-5. doi: 10.1513/pats.200402-016MS. Proc Am Thorac Soc. 2004. PMID: 16113431 Review.
The evidence suggests that the effect of ICSs on bone mineral density is small in the short term but that patients taking moderate or high doses for long periods will be at increased risk of fractures and that this could be an appreciable public health problem. There is al …
The evidence suggests that the effect of ICSs on bone mineral density is small in the short term but that patients taking moderate or …
Effects of inhaled corticosteroids on bone.
Mortimer KJ, Harrison TW, Tattersfield AE. Mortimer KJ, et al. Among authors: tattersfield ae. Ann Allergy Asthma Immunol. 2005 Jan;94(1):15-21; quiz 22-3, 79. doi: 10.1016/S1081-1206(10)61280-X. Ann Allergy Asthma Immunol. 2005. PMID: 15702810 Review.
Three cross-sectional studies found a dose-related increase in fractures in people taking an inhaled corticosteroid compared with controls. Prospective studies found a short-term reduction in growth velocity in children taking an inhaled corticosteroid, although target adu …
Three cross-sectional studies found a dose-related increase in fractures in people taking an inhaled corticosteroid compared with controls. …
A benefit-risk assessment of inhaled long-acting beta2-agonists in the management of obstructive pulmonary disease.
Sovani MP, Whale CI, Tattersfield AE. Sovani MP, et al. Among authors: tattersfield ae. Drug Saf. 2004;27(10):689-715. doi: 10.2165/00002018-200427100-00001. Drug Saf. 2004. PMID: 15350154 Review.
In this review we consider the evidence for their efficacy and safety in adults with asthma and chronic obstructive pulmonary disease (COPD), by reviewing long-term prospective studies in which these drugs have been compared with placebo or an alternative bronchodilator. . …
In this review we consider the evidence for their efficacy and safety in adults with asthma and chronic obstructive pulmonary disease (COPD) …
Plasma concentrations of fluticasone propionate and budesonide following inhalation from dry powder inhalers by healthy and asthmatic subjects.
Harrison TW, Tattersfield AE. Harrison TW, et al. Among authors: tattersfield ae. Thorax. 2003 Mar;58(3):258-60. doi: 10.1136/thorax.58.3.258. Thorax. 2003. PMID: 12612308 Free PMC article. Clinical Trial.
BACKGROUND: All currently available inhaled corticosteroids reach the systemic circulation and have the potential to produce adverse effects with long term use. This risk is often assessed by measuring the effect of different inhaled corticosteroids on the hypothalamic-pit …
BACKGROUND: All currently available inhaled corticosteroids reach the systemic circulation and have the potential to produce adverse effects …
The impact of oral corticosteroid use on bone mineral density and vertebral fracture.
Walsh LJ, Lewis SA, Wong CA, Cooper S, Oborne J, Cawte SA, Harrison T, Green DJ, Pringle M, Hubbard R, Tattersfield AE. Walsh LJ, et al. Among authors: tattersfield ae. Am J Respir Crit Care Med. 2002 Sep 1;166(5):691-5. doi: 10.1164/rccm.2110047. Am J Respir Crit Care Med. 2002. PMID: 12204867
The difference in femoral neck BMD between the same dose quartiles was only modest, however (0.5 SD; 95% confidence interval, 0.09, 0.94). In patients taking long-term oral corticosteroids for chronic lung disease, the relationship between vertebral fracture risk and BMD i …
The difference in femoral neck BMD between the same dose quartiles was only modest, however (0.5 SD; 95% confidence interval, 0.09, 0.94). I …
Adverse effects of oral corticosteroids in relation to dose in patients with lung disease.
Walsh LJ, Wong CA, Oborne J, Cooper S, Lewis SA, Pringle M, Hubbard R, Tattersfield AE. Walsh LJ, et al. Among authors: tattersfield ae. Thorax. 2001 Apr;56(4):279-84. doi: 10.1136/thorax.56.4.279. Thorax. 2001. PMID: 11254818 Free PMC article. Clinical Trial.
CONCLUSIONS: By quantifying the morbidity associated with the use of oral corticosteroids, this study should help to rationalise their long term use....
CONCLUSIONS: By quantifying the morbidity associated with the use of oral corticosteroids, this study should help to rationalise their long …
Comparison of the systemic effects of fluticasone propionate and budesonide given by dry powder inhaler in healthy and asthmatic subjects.
Harrison TW, Wisniewski A, Honour J, Tattersfield AE. Harrison TW, et al. Among authors: tattersfield ae. Thorax. 2001 Mar;56(3):186-91. doi: 10.1136/thorax.56.3.186. Thorax. 2001. PMID: 11182010 Free PMC article. Clinical Trial.
BACKGROUND: The potential for long term adverse effects from inhaled corticosteroids relates to their systemic absorption, usually assessed from proxy markers in short term studies. ...
BACKGROUND: The potential for long term adverse effects from inhaled corticosteroids relates to their systemic absorption, usually as …
Asthma quality of life during 1 year of treatment with budesonide with or without formoterol.
Juniper EF, Svensson K, O'Byrne PM, Barnes PJ, Bauer CA, Löfdahl CG, Postma DS, Pauwels RA, Tattersfield AE, Ullman A. Juniper EF, et al. Among authors: tattersfield ae. Eur Respir J. 1999 Nov;14(5):1038-43. doi: 10.1183/09031936.99.14510389. Eur Respir J. 1999. PMID: 10596687 Free article. Clinical Trial.
The Formoterol and Corticosteroids Establishing Therapy (FACET) study has provided the first opportunity to examine the long-term effects of inhaled steroids and long-acting beta2-agonists on asthma-specific quality of life. The objectives of the present study were to: eva …
The Formoterol and Corticosteroids Establishing Therapy (FACET) study has provided the first opportunity to examine the long-term eff …
16 results