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Cardiopulmonary Consequences of Vaping in Adolescents: A Scientific Statement From the American Heart Association.
Wold LE, Tarran R, Crotty Alexander LE, Hamburg NM, Kheradmand F, St Helen G, Wu JC; American Heart Association Council on Basic Cardiovascular Sciences; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Hypertension; and Stroke Council. Wold LE, et al. Among authors: tarran r. Circ Res. 2022 Jul 22;131(3):e70-e82. doi: 10.1161/RES.0000000000000544. Epub 2022 Jun 21. Circ Res. 2022. PMID: 35726609 Free article. Review.
The goals of this scientific statement are to provide salient background information on the cardiopulmonary consequences of e-cigarette use (vaping) in adolescents, to guide therapeutic and preventive strategies and future research directions, and to inform public policymakers on …
The goals of this scientific statement are to provide salient background information on the cardiopulmonary consequences of e-cigarette use …
E-Cigarettes and Cardiopulmonary Health: Review for Clinicians.
Neczypor EW, Mears MJ, Ghosh A, Sassano MF, Gumina RJ, Wold LE, Tarran R. Neczypor EW, et al. Among authors: tarran r. Circulation. 2022 Jan 18;145(3):219-232. doi: 10.1161/CIRCULATIONAHA.121.056777. Epub 2022 Jan 18. Circulation. 2022. PMID: 35041473 Free PMC article. Review.
E-cigarettes became commercially available without evidence regarding their risks, long-term safety, or utility in smoking cessation. Recent clinical trials suggest that e-cigarette use with counseling may be effective in reducing cigarette use but not nicotine dependence. …
E-cigarettes became commercially available without evidence regarding their risks, long-term safety, or utility in smoking cessation. …
SPLUNC1: a novel marker of cystic fibrosis exacerbations.
Khanal S, Webster M, Niu N, Zielonka J, Nunez M, Chupp G, Slade MD, Cohn L, Sauler M, Gomez JL, Tarran R, Sharma L, Dela Cruz CS, Egan M, Laguna T, Britto CJ. Khanal S, et al. Among authors: tarran r. Eur Respir J. 2021 Nov 11;58(5):2000507. doi: 10.1183/13993003.00507-2020. Print 2021 Nov. Eur Respir J. 2021. PMID: 33958427 Free PMC article.
In asymptomatic, stable patients, low SPLUNC1 levels could inform changes in clinical management to improve long-term disease control and clinical outcomes in CF....
In asymptomatic, stable patients, low SPLUNC1 levels could inform changes in clinical management to improve long-term disease control …
E-Cigarettes and Cardiopulmonary Health.
Tarran R, Barr RG, Benowitz NL, Bhatnagar A, Chu HW, Dalton P, Doerschuk CM, Drummond MB, Gold DR, Goniewicz ML, Gross ER, Hansel NN, Hopke PK, Kloner RA, Mikheev VB, Neczypor EW, Pinkerton KE, Postow L, Rahman I, Samet JM, Salathe M, Stoney CM, Tsao PS, Widome R, Xia T, Xiao D, Wold LE. Tarran R, et al. Function (Oxf). 2021 Feb 8;2(2):zqab004. doi: 10.1093/function/zqab004. eCollection 2021. Function (Oxf). 2021. PMID: 33748758 Free PMC article. Review.
Although the use of combustible cigarettes is associated with several adverse health effects including multiple pulmonary and cardiovascular diseases, the effects of e-cigarettes on both short- and long-term health have only begun to be investigated. Given the recent incre …
Although the use of combustible cigarettes is associated with several adverse health effects including multiple pulmonary and cardiovascular …
E-cigarette constituents propylene glycol and vegetable glycerin decrease glucose uptake and its metabolism in airway epithelial cells in vitro.
Woodall M, Jacob J, Kalsi KK, Schroeder V, Davis E, Kenyon B, Khan I, Garnett JP, Tarran R, Baines DL. Woodall M, et al. Among authors: tarran r. Am J Physiol Lung Cell Mol Physiol. 2020 Dec 1;319(6):L957-L967. doi: 10.1152/ajplung.00123.2020. Epub 2020 Sep 30. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 32996783 Free PMC article.
Puffing PG/VG vapor onto the apical surface of primary HBECs for 10 min to mimic the effect of e-cigarette smoking also reduced glucose transport. In conclusion, short-term exposure to PG/VG, key components of e-cigarettes, decreased glucose transport and metabolism in air …
Puffing PG/VG vapor onto the apical surface of primary HBECs for 10 min to mimic the effect of e-cigarette smoking also reduced glucose tran …
Flavored e-liquids increase cytoplasmic Ca2+ levels in airway epithelia.
Rowell TR, Keating JE, Zorn BT, Glish GL, Shears SB, Tarran R. Rowell TR, et al. Among authors: tarran r. Am J Physiol Lung Cell Mol Physiol. 2020 Feb 1;318(2):L226-L241. doi: 10.1152/ajplung.00123.2019. Epub 2019 Nov 6. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 31693394 Free PMC article.
However, longer exposures to BP e-liquid depleted ER Ca(2+) stores and inhibited SOCE, suggesting that this e-liquid may alter Ca(2+) homeostasis by short- and long-term mechanisms. Since dysregulation of Ca(2+) signaling can cause chronic inflammation, ER stress, and abno …
However, longer exposures to BP e-liquid depleted ER Ca(2+) stores and inhibited SOCE, suggesting that this e-liquid may alter Ca(2+) homeos …
What are the respiratory effects of e-cigarettes?
Gotts JE, Jordt SE, McConnell R, Tarran R. Gotts JE, et al. Among authors: tarran r. BMJ. 2019 Sep 30;366:l5275. doi: 10.1136/bmj.l5275. BMJ. 2019. PMID: 31570493 Free PMC article. Review.
E-cigarettes reached the market without either extensive preclinical toxicology testing or long term safety trials that would be required of conventional therapeutics or medical devices. ...
E-cigarettes reached the market without either extensive preclinical toxicology testing or long term safety trials that would be requ …
Chronic E-Cigarette Exposure Alters the Human Bronchial Epithelial Proteome.
Ghosh A, Coakley RC, Mascenik T, Rowell TR, Davis ES, Rogers K, Webster MJ, Dang H, Herring LE, Sassano MF, Livraghi-Butrico A, Van Buren SK, Graves LM, Herman MA, Randell SH, Alexis NE, Tarran R. Ghosh A, et al. Among authors: tarran r. Am J Respir Crit Care Med. 2018 Jul 1;198(1):67-76. doi: 10.1164/rccm.201710-2033OC. Am J Respir Crit Care Med. 2018. PMID: 29481290 Free PMC article.
RATIONALE: E-cigarettes vaporize propylene glycol/vegetable glycerin (PG/VG), nicotine, and flavorings. However, the long-term health effects of exposing lungs to vaped e-liquids are unknown. ...
RATIONALE: E-cigarettes vaporize propylene glycol/vegetable glycerin (PG/VG), nicotine, and flavorings. However, the long-term health …
Cigarette smoke-induced Ca2+ release leads to cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction.
Rasmussen JE, Sheridan JT, Polk W, Davies CM, Tarran R. Rasmussen JE, et al. Among authors: tarran r. J Biol Chem. 2014 Mar 14;289(11):7671-81. doi: 10.1074/jbc.M113.545137. Epub 2014 Jan 21. J Biol Chem. 2014. PMID: 24448802 Free PMC article.
Our data provide mechanistic insight into the potentially deleterious effects of CS on airway epithelia and outline a hitherto unrecognized signaling event triggered by CS that may affect the long term transition of the lung into a hyper-inflammatory/dehydrated environment …
Our data provide mechanistic insight into the potentially deleterious effects of CS on airway epithelia and outline a hitherto unrecognized …
Rationale for hypertonic saline therapy for cystic fibrosis lung disease.
Tarran R, Donaldson S, Boucher RC. Tarran R, et al. Semin Respir Crit Care Med. 2007 Jun;28(3):295-302. doi: 10.1055/s-2007-981650. Semin Respir Crit Care Med. 2007. PMID: 17562499 Review.
Rehydrating airway surfaces may reduce or prevent lung injury and damage. Short- and longer term studies have shown that inhalation of hypertonic saline is well tolerated and improves lung function, reduces exacerbations, and improves quality of life in CF patients. ...
Rehydrating airway surfaces may reduce or prevent lung injury and damage. Short- and longer term studies have shown that inhalation o …
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