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Human skeletal muscle mitochondrial responses to single-leg intermittent or continuous cycle exercise training matched for absolute intensity and total work.
Skelly LE, MacInnis MJ, Bostad W, McCarthy DG, Jenkins EM, Archila LR, Tarnopolsky MA, Gibala MJ. Skelly LE, et al. Among authors: tarnopolsky ma. Scand J Med Sci Sports. 2023 Jun;33(6):872-881. doi: 10.1111/sms.14332. Epub 2023 Feb 22. Scand J Med Sci Sports. 2023. PMID: 36779702
We employed single-leg cycling to facilitate a within-participant design and test the hypothesis that short-term INT training would elicit a greater increase in mitochondrial content than work- and intensity-matched CONT training. ...Both training modes increased single-le …
We employed single-leg cycling to facilitate a within-participant design and test the hypothesis that short-term INT training would e …
Extracellular Vesicles and Exosomes: Insights From Exercise Science.
Nederveen JP, Warnier G, Di Carlo A, Nilsson MI, Tarnopolsky MA. Nederveen JP, et al. Among authors: tarnopolsky ma. Front Physiol. 2021 Feb 1;11:604274. doi: 10.3389/fphys.2020.604274. eCollection 2020. Front Physiol. 2021. PMID: 33597890 Free PMC article. Review.
This review aims to summarize our current understanding of the effects of exercise on MVs and ELVs, examine their role in the exercise response and long-term adaptations, and highlight the main methodological hurdles related to blood collection, purification, and character …
This review aims to summarize our current understanding of the effects of exercise on MVs and ELVs, examine their role in the exercise respo …
Acute, Exercise-Induced Alterations in Cytokines and Chemokines in the Blood Distinguish Physically Active and Sedentary Aging.
MacNeil LG, Tarnopolsky MA, Crane JD. MacNeil LG, et al. Among authors: tarnopolsky ma. J Gerontol A Biol Sci Med Sci. 2021 Apr 30;76(5):811-818. doi: 10.1093/gerona/glaa310. J Gerontol A Biol Sci Med Sci. 2021. PMID: 33289019 Free PMC article.
However, sedentary individuals, particularly the elderly, had few detectable changes in response to exercise. Overall, we show that long-term physical activity has a limited effect on age-associated changes in basal cytokines and chemokines in the healthy elderly, yet phys …
However, sedentary individuals, particularly the elderly, had few detectable changes in response to exercise. Overall, we show that long- …
Missense variants in the N-terminal domain of the A isoform of FHF2/FGF13 cause an X-linked developmental and epileptic encephalopathy.
Fry AE, Marra C, Derrick AV, Pickrell WO, Higgins AT, Te Water Naude J, McClatchey MA, Davies SJ, Metcalfe KA, Tan HJ, Mohanraj R, Avula S, Williams D, Brady LI, Mesterman R, Tarnopolsky MA, Zhang Y, Yang Y, Wang X; Genomics England Research Consortium; Rees MI, Goldfarb M, Chung SK. Fry AE, et al. Among authors: tarnopolsky ma. Am J Hum Genet. 2021 Jan 7;108(1):176-185. doi: 10.1016/j.ajhg.2020.10.017. Epub 2020 Nov 26. Am J Hum Genet. 2021. PMID: 33245860 Free PMC article.
Functional characterization of mutant FHF2A co-expressed with wild-type Na(v)1.6 (SCN8A) revealed that mutant FHF2A proteins lost the ability to induce rapid-onset, long-term blockade of the channel while retaining pro-excitatory properties. ...
Functional characterization of mutant FHF2A co-expressed with wild-type Na(v)1.6 (SCN8A) revealed that mutant FHF2A proteins lost the abilit …
Effect of short-term, high-intensity exercise training on human skeletal muscle citrate synthase maximal activity: single versus multiple bouts per session.
MacInnis MJ, Skelly LE, Godkin FE, Martin BJ, Tripp TR, Tarnopolsky MA, Gibala MJ. MacInnis MJ, et al. Among authors: tarnopolsky ma. Appl Physiol Nutr Metab. 2019 Dec;44(12):1391-1394. doi: 10.1139/apnm-2019-0403. Epub 2019 Oct 16. Appl Physiol Nutr Metab. 2019. PMID: 31618598 Clinical Trial.
Needle biopsies from vastus lateralis revealed that citrate synthase maximal activity increased after training in the 4-bout group (p = 0.035) but not the 1-bout group (p = 0.10), with a significant difference between groups post-training (13%, p = 0.021). Novelty Short-term …
Needle biopsies from vastus lateralis revealed that citrate synthase maximal activity increased after training in the 4-bout group (p = 0.03 …
Skeletal muscle fiber-type-specific changes in markers of capillary and mitochondrial content after low-volume interval training in overweight women.
Tan R, Nederveen JP, Gillen JB, Joanisse S, Parise G, Tarnopolsky MA, Gibala MJ. Tan R, et al. Among authors: tarnopolsky ma. Physiol Rep. 2018 Mar;6(5):e13597. doi: 10.14814/phy2.13597. Physiol Rep. 2018. PMID: 29484852 Free PMC article.
POST: 3863 1307 arbitrary units; main effect, P < 0.01). We conclude that short-term HIIT in previously inactive women similarly increases markers of capillary density and mitochondrial content in type I and type II fibers....

POST: 3863 1307 arbitrary units; main effect, P < 0.01). We conclude that short-term HIIT in previously inactive women similarly i

…
Manipulating Carbohydrate Availability Between Twice-Daily Sessions of High-Intensity Interval Training Over 2 Weeks Improves Time-Trial Performance.
Cochran AJ, Myslik F, MacInnis MJ, Percival ME, Bishop D, Tarnopolsky MA, Gibala MJ. Cochran AJ, et al. Among authors: tarnopolsky ma. Int J Sport Nutr Exerc Metab. 2015 Oct;25(5):463-70. doi: 10.1123/ijsnem.2014-0263. Epub 2015 Mar 26. Int J Sport Nutr Exerc Metab. 2015. PMID: 25811132
The training-induced improvement in 250-kJ time trial performance was greater (p = .02) in the HI-LO group (211 66 W to 244 75 W) compared with the HI-HI group (203 53 W to 219 60 W); however, the increases in mitochondrial content was similar between groups, as reflected by simi …
The training-induced improvement in 250-kJ time trial performance was greater (p = .02) in the HI-LO group (211 66 W to 244 75 W) compared w …
Three minutes of all-out intermittent exercise per week increases skeletal muscle oxidative capacity and improves cardiometabolic health.
Gillen JB, Percival ME, Skelly LE, Martin BJ, Tan RB, Tarnopolsky MA, Gibala MJ. Gillen JB, et al. Among authors: tarnopolsky ma. PLoS One. 2014 Nov 3;9(11):e111489. doi: 10.1371/journal.pone.0111489. eCollection 2014. PLoS One. 2014. PMID: 25365337 Free PMC article.
This was associated with a greater increase in GLUT4 protein content in men compared to women (138% vs. 23%, p<0.05). Short-term interval training using a 10 min protocol that involved only 1 min of hard exercise, 3x/wk, stimulated physiological changes linked to improv …
This was associated with a greater increase in GLUT4 protein content in men compared to women (138% vs. 23%, p<0.05). Short-term i …
Fluvastatin causes NLRP3 inflammasome-mediated adipose insulin resistance.
Henriksbo BD, Lau TC, Cavallari JF, Denou E, Chi W, Lally JS, Crane JD, Duggan BM, Foley KP, Fullerton MD, Tarnopolsky MA, Steinberg GR, Schertzer JD. Henriksbo BD, et al. Among authors: tarnopolsky ma. Diabetes. 2014 Nov;63(11):3742-7. doi: 10.2337/db13-1398. Epub 2014 Jun 10. Diabetes. 2014. PMID: 24917577
This effect was dose dependent, absent in NLRP3(-/-) mice, and prevented by caspase-1 inhibition or the diabetes drug glyburide. Long-term fluvastatin treatment of obese mice impaired insulin-stimulated glucose uptake in adipose tissue. ...
This effect was dose dependent, absent in NLRP3(-/-) mice, and prevented by caspase-1 inhibition or the diabetes drug glyburide. Long-ter …
Functional impairment in patients with sporadic Inclusion Body Myositis.
Dunlap HV, Macneil LG, Tarnopolsky MA. Dunlap HV, et al. Among authors: tarnopolsky ma. Can J Neurol Sci. 2014 Mar;41(2):253-9. doi: 10.1017/s0317167100016668. Can J Neurol Sci. 2014. PMID: 24534039
Further investigations concerning gait assistive device use and patient history of falling would be beneficial in preventing future falls and improving long-term patient outcomes....
Further investigations concerning gait assistive device use and patient history of falling would be beneficial in preventing future falls an …
44 results