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Most Pathways Can Be Related to the Pathogenesis of Alzheimer's Disease.
Morgan SL, Naderi P, Koler K, Pita-Juarez Y, Prokopenko D, Vlachos IS, Tanzi RE, Bertram L, Hide WA. Morgan SL, et al. Among authors: tanzi re. Front Aging Neurosci. 2022 Jun 24;14:846902. doi: 10.3389/fnagi.2022.846902. eCollection 2022. Front Aging Neurosci. 2022. PMID: 35813951 Free PMC article.
Despite major technological advances, the same set of top-ranked pathways have been consistently related to AD for 30 years, including AD, immune system, metabolic pathways, cholinergic synapse, long-term depression, proteasome, diabetes, cancer, and chemokine signaling. . …
Despite major technological advances, the same set of top-ranked pathways have been consistently related to AD for 30 years, including AD, i …
Long-term survival of participants in the CENTAUR trial of sodium phenylbutyrate-taurursodiol in amyotrophic lateral sclerosis.
Paganoni S, Hendrix S, Dickson SP, Knowlton N, Macklin EA, Berry JD, Elliott MA, Maiser S, Karam C, Caress JB, Owegi MA, Quick A, Wymer J, Goutman SA, Heitzman D, Heiman-Patterson TD, Jackson CE, Quinn C, Rothstein JD, Kasarskis EJ, Katz J, Jenkins L, Ladha S, Miller TM, Scelsa SN, Vu TH, Fournier CN, Glass JD, Johnson KM, Swenson A, Goyal NA, Pattee GL, Andres PL, Babu S, Chase M, Dagostino D, Hall M, Kittle G, Eydinov M, McGovern M, Ostrow J, Pothier L, Randall R, Shefner JM, Sherman AV, St Pierre ME, Tustison E, Vigneswaran P, Walker J, Yu H, Chan J, Wittes J, Yu ZF, Cohen J, Klee J, Leslie K, Tanzi RE, Gilbert W, Yeramian PD, Schoenfeld D, Cudkowicz ME. Paganoni S, et al. Among authors: tanzi re. Muscle Nerve. 2021 Jan;63(1):31-39. doi: 10.1002/mus.27091. Epub 2020 Oct 30. Muscle Nerve. 2021. PMID: 33063909 Free PMC article. Clinical Trial.
An orally administered, fixed-dose coformulation of sodium phenylbutyrate-taurursodiol (PB-TURSO) significantly slowed functional decline in a randomized, placebo-controlled, phase 2 trial in ALS (CENTAUR). Herein we report results of a long-term survival analysis of parti …
An orally administered, fixed-dose coformulation of sodium phenylbutyrate-taurursodiol (PB-TURSO) significantly slowed functional decline in …
In Vivo Quasi-Elastic Light Scattering Eye Scanner Detects Molecular Aging in Humans.
Minaeva O, Sarangi S, Ledoux DM, Moncaster JA, Parsons DS, Washicosky KJ, Black CA, Weng FJ, Ericsson M, Moir RD, Tripodis Y, Clark JI, Tanzi RE, Hunter DG, Goldstein LE. Minaeva O, et al. Among authors: tanzi re. J Gerontol A Biol Sci Med Sci. 2020 Sep 16;75(9):e53-e62. doi: 10.1093/gerona/glaa121. J Gerontol A Biol Sci Med Sci. 2020. PMID: 32515825 Free PMC article.
Age-dependent QLS signal changes detected in vivo recapitulated time-dependent changes in hydrodynamic radius, protein polydispersity, and supramolecular order of human lens proteins during long-term incubation (~1 year) and in response to sustained oxidation (~2.5 months) …
Age-dependent QLS signal changes detected in vivo recapitulated time-dependent changes in hydrodynamic radius, protein polydispersity, and s …
FlyNet 2.0: drosophila heart 3D (2D + time) segmentation in optical coherence microscopy images using a convolutional long short-term memory neural network.
Dong Z, Men J, Yang Z, Jerwick J, Li A, Tanzi RE, Zhou C. Dong Z, et al. Among authors: tanzi re. Biomed Opt Express. 2020 Feb 21;11(3):1568-1579. doi: 10.1364/BOE.385968. eCollection 2020 Mar 1. Biomed Opt Express. 2020. PMID: 32206429 Free PMC article.
A custom convolutional neural network (CNN) integrated with convolutional long short-term memory (LSTM) achieves accurate 3D (2D + time) segmentation in cross-sectional videos of the Drosophila heart acquired by an optical coherence microscopy (OCM) system. ...
A custom convolutional neural network (CNN) integrated with convolutional long short-term memory (LSTM) achieves accurate 3D (2D + ti …
Developing Effective Alzheimer's Disease Therapies: Clinical Experience and Future Directions.
Elmaleh DR, Farlow MR, Conti PS, Tompkins RG, Kundakovic L, Tanzi RE. Elmaleh DR, et al. Among authors: tanzi re. J Alzheimers Dis. 2019;71(3):715-732. doi: 10.3233/JAD-190507. J Alzheimers Dis. 2019. PMID: 31476157 Free PMC article. Review.
Here we highlight the potential reasons that have hindered clinical success, including clinical trial design and choice of outcome measures, heterogeneity of patient populations, difficulties in diagnosing and staging the disease, drug design, mechanism of action, and toxicity re …
Here we highlight the potential reasons that have hindered clinical success, including clinical trial design and choice of outcome measures, …
The Amazon rain forest plant Uncaria tomentosa (cat's claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles.
Snow AD, Castillo GM, Nguyen BP, Choi PY, Cummings JA, Cam J, Hu Q, Lake T, Pan W, Kastin AJ, Kirschner DA, Wood SG, Rockenstein E, Masliah E, Lorimer S, Tanzi RE, Larsen L. Snow AD, et al. Among authors: tanzi re. Sci Rep. 2019 Feb 6;9(1):561. doi: 10.1038/s41598-019-38645-0. Sci Rep. 2019. PMID: 30728442 Free PMC article.
One major identified specific polyphenol within PTI-00703 cat's claw was epicatechin-4beta-8-epicatechin (i.e. an epicatechin dimer known as proanthocyanidin B2) that markedly reduced brain plaque load and improved short-term memory in younger and older APP "plaque-produci …
One major identified specific polyphenol within PTI-00703 cat's claw was epicatechin-4beta-8-epicatechin (i.e. an epicatechin dimer known as …
CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 N141I neurons.
Ortiz-Virumbrales M, Moreno CL, Kruglikov I, Marazuela P, Sproul A, Jacob S, Zimmer M, Paull D, Zhang B, Schadt EE, Ehrlich ME, Tanzi RE, Arancio O, Noggle S, Gandy S. Ortiz-Virumbrales M, et al. Among authors: tanzi re. Acta Neuropathol Commun. 2017 Oct 27;5(1):77. doi: 10.1186/s40478-017-0475-z. Acta Neuropathol Commun. 2017. PMID: 29078805 Free PMC article.
Basal forebrain cholinergic neurons (BFCNs) are believed to be one of the first cell types to be affected in all forms of AD, and their dysfunction is clinically correlated with impaired short-term memory formation and retrieval. We present an optimized in vitro protocol t …
Basal forebrain cholinergic neurons (BFCNs) are believed to be one of the first cell types to be affected in all forms of AD, and their dysf …
Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer's disease.
Minter MR, Hinterleitner R, Meisel M, Zhang C, Leone V, Zhang X, Oyler-Castrillo P, Zhang X, Musch MW, Shen X, Jabri B, Chang EB, Tanzi RE, Sisodia SS. Minter MR, et al. Among authors: tanzi re. Sci Rep. 2017 Sep 5;7(1):10411. doi: 10.1038/s41598-017-11047-w. Sci Rep. 2017. PMID: 28874832 Free PMC article.
We show that early post-natal (P) ABX treatment (P14-P21) results in long-term alterations of gut microbial genera (predominantly Lachnospiraceae and S24-7) and reduction in brain Abeta deposition in aged APP(SWE)/PS1(deltaE9) mice. ...
We show that early post-natal (P) ABX treatment (P14-P21) results in long-term alterations of gut microbial genera (predominantly Lac …
Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease.
Minter MR, Zhang C, Leone V, Ringus DL, Zhang X, Oyler-Castrillo P, Musch MW, Liao F, Ward JF, Holtzman DM, Chang EB, Tanzi RE, Sisodia SS. Minter MR, et al. Among authors: tanzi re. Sci Rep. 2016 Jul 21;6:30028. doi: 10.1038/srep30028. Sci Rep. 2016. PMID: 27443609 Free PMC article.
We show that prolonged shifts in gut microbial composition and diversity induced by long-term broad-spectrum combinatorial antibiotic treatment regime decreases Abeta plaque deposition. ...
We show that prolonged shifts in gut microbial composition and diversity induced by long-term broad-spectrum combinatorial antibiotic …
The Self-Directed Biological Transformation Initiative and Well-Being.
Mills PJ, Wilson KL, Pung MA, Weiss L, Patel S, Doraiswamy PM, Peterson CT, Porter V, Schadt E, Chopra D, Tanzi RE. Mills PJ, et al. Among authors: tanzi re. J Altern Complement Med. 2016 Aug;22(8):627-34. doi: 10.1089/acm.2016.0002. Epub 2016 Jun 28. J Altern Complement Med. 2016. PMID: 27351443 Clinical Trial.

The Ayurvedic participants also showed increased ratings for self-compassion (p < 0.01) as well as less anxiety at the 1-month follow-up (p < 0.05). CONCLUSIONS: Findings suggest that a short-term intensive program providing holistic instruction and experience in min

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The Ayurvedic participants also showed increased ratings for self-compassion (p < 0.01) as well as less anxiety at the 1-month follow-up

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20 results