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Targeting PSEN1 by lnc-CYP3A43-2/miR-29b-2-5p to Reduce β Amyloid Plaque Formation and Improve Cognition Function.
Wuli W, Lin SZ, Chen SP, Tannous BA, Huang WS, Woon PY, Wu YC, Yang HH, Chen YC, Fleming RL, Rogers JT, Cahill CM, Ho TJ, Chiou TW, Harn HJ. Wuli W, et al. Among authors: tannous ba. Int J Mol Sci. 2022 Sep 11;23(18):10554. doi: 10.3390/ijms231810554. Int J Mol Sci. 2022. PMID: 36142465 Free PMC article.
Bioinformatics tool prediction analysis, biotin-labeled miR-29b-2-5p pull-down assay, and dual-luciferase reporter assay confirmed a direct negative regulatory effect for miRNA29b-2-5p on lnc-RNA-CYP3A43-2 and PSEN1. Moreover, BP administration improved short-term memory a …
Bioinformatics tool prediction analysis, biotin-labeled miR-29b-2-5p pull-down assay, and dual-luciferase reporter assay confirmed a direct …
Small but Fierce: Tracking the Role of Extracellular Vesicles in Glioblastoma Progression and Therapeutic Resistance.
Schweiger MW, Tannous BA. Schweiger MW, et al. Among authors: tannous ba. Adv Biosyst. 2020 Dec;4(12):e2000035. doi: 10.1002/adbi.202000035. Epub 2020 Sep 3. Adv Biosyst. 2020. PMID: 32881418 Free PMC article. Review.
Glioblastoma is the most common and aggressive brain tumor in adults. Most patients die within a year and long-term survival remains rare, owing to a combination of rapid progression/degeneration, lack of successful treatments, and high recurrence rates. ...
Glioblastoma is the most common and aggressive brain tumor in adults. Most patients die within a year and long-term survival remains …
Extracellular Vesicles Induce Mesenchymal Transition and Therapeutic Resistance in Glioblastomas through NF-κB/STAT3 Signaling.
Schweiger MW, Li M, Giovanazzi A, Fleming RL, Tabet EI, Nakano I, Würdinger T, Chiocca EA, Tian T, Tannous BA. Schweiger MW, et al. Among authors: tannous ba. Adv Biosyst. 2020 Dec;4(12):e1900312. doi: 10.1002/adbi.201900312. Epub 2020 Jun 9. Adv Biosyst. 2020. PMID: 32519463 Free PMC article.
Glioblastoma (GBM) is the most common primary malignant brain tumor and despite optimal treatment, long-term survival remains uncommon. GBM can be roughly divided into three different molecular subtypes, each varying in aggressiveness and treatment resistance. ...
Glioblastoma (GBM) is the most common primary malignant brain tumor and despite optimal treatment, long-term survival remains uncommo …
Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1.
Prabhakar S, Cheah PS, Zhang X, Zinter M, Gianatasio M, Hudry E, Bronson RT, Kwiatkowski DJ, Stemmer-Rachamimov A, Maguire CA, Sena-Esteves M, Tannous BA, Breakefield XO. Prabhakar S, et al. Among authors: tannous ba. Mol Ther Methods Clin Dev. 2019 Aug 16;15:18-26. doi: 10.1016/j.omtm.2019.08.003. eCollection 2019 Dec 13. Mol Ther Methods Clin Dev. 2019. PMID: 31534984 Free PMC article.
In a stochastic mouse model of TSC1 brain lesions, complete loss of Tsc1 is achieved in homozygous Tsc1-floxed mice in a subpopulation of neural cells in the brain by intracerebroventricular (i.c.v.) injection at birth of an adeno-associated virus (AAV) vector encoding Cre …
In a stochastic mouse model of TSC1 brain lesions, complete loss of Tsc1 is achieved in homozygous Tsc1-floxed mice in a subpopulation of ne …
A chemical screen for medulloblastoma identifies quercetin as a putative radiosensitizer.
Lagerweij T, Hiddingh L, Biesmans D, Crommentuijn MH, Cloos J, Li XN, Kogiso M, Tannous BA, Vandertop WP, Noske DP, Kaspers GJ, Würdinger T, Hulleman E. Lagerweij T, et al. Among authors: tannous ba. Oncotarget. 2016 Jun 14;7(24):35776-35788. doi: 10.18632/oncotarget.7980. Oncotarget. 2016. PMID: 26967057 Free PMC article.
Therefore, more effective drugs are needed that spare normal tissue and diminish long-term side effects. Since radiotherapy plays a pivotal role in the treatment of medulloblastoma, we set out to identify novel drugs that could potentiate the effect of ionizing radiation.T …
Therefore, more effective drugs are needed that spare normal tissue and diminish long-term side effects. Since radiotherapy plays a p …
Advances in stem cell therapy against gliomas.
Bovenberg MS, Degeling MH, Tannous BA. Bovenberg MS, et al. Among authors: tannous ba. Trends Mol Med. 2013 May;19(5):281-91. doi: 10.1016/j.molmed.2013.03.001. Epub 2013 Mar 25. Trends Mol Med. 2013. PMID: 23537753 Review.
Stem cell-based therapy using neural, mesenchymal, or hematopoietic stem cells may be an alternative approach because it is tumor selective and allows targeted therapy that spares healthy brain tissue. Stem cells can be used to establish a long-term antitumor response by s …
Stem cell-based therapy using neural, mesenchymal, or hematopoietic stem cells may be an alternative approach because it is tumor selective …