Deletion of mFICD AMPylase alters cytokine secretion and affects visual short-term learning in vivo.
McCaul N, Porter CM, Becker A, Tang CA, Wijne C, Chatterjee B, Bousbaine D, Bilate A, Hu CA, Ploegh H, Truttmann MC.
McCaul N, et al.
J Biol Chem. 2021 Sep;297(3):100991. doi: 10.1016/j.jbc.2021.100991. Epub 2021 Aug 19.
J Biol Chem. 2021.
PMID: 34419450
Free PMC article.
We also show that mFICD-deficient mouse embryonic fibroblasts are depleted of AMPylated proteins. mFICD deletion alters protein synthesis and secretion in splenocytes, including that of IgM, an antibody secreted early during infections, and the proinflammatory cytokine IL-1beta, …
We also show that mFICD-deficient mouse embryonic fibroblasts are depleted of AMPylated proteins. mFICD deletion alters protein synthesis an …