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Effects of chronic tamoxifen treatment in female rat sexual behaviour.
Pinto CA, Fonseca BM, Sá SI. Pinto CA, et al. Heliyon. 2022 Dec 17;8(12):e12362. doi: 10.1016/j.heliyon.2022.e12362. eCollection 2022 Dec. Heliyon. 2022. PMID: 36593822 Free PMC article.
With the objective to assess TAM action in the brain areas involved in the modulation sexual cues, an animal model on long-term TAM therapy to intact female rats, was used to mimic the 5-year prophylactic TAM therapy offered to women at higher risk of breast cancer. …
With the objective to assess TAM action in the brain areas involved in the modulation sexual cues, an animal model on long-term TA …
Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo.
Lin HY, Han HW, Wang YS, He DL, Sun WX, Feng L, Wen ZL, Yang MK, Lu GH, Wang XM, Qi JL, Yang YH. Lin HY, et al. Chin Med. 2020 Mar 10;15:23. doi: 10.1186/s13020-020-00305-1. eCollection 2020. Chin Med. 2020. PMID: 32175001 Free PMC article.
BACKGROUND: Tamoxifen (TAM) is a cell type-specific anti-estrogen and is applied to improve the survival of patients with estrogen receptor positive (ER +) breast cancer. However, long-term TAM use can induce serious drug resistance, leading to breast cancer recurre …
BACKGROUND: Tamoxifen (TAM) is a cell type-specific anti-estrogen and is applied to improve the survival of patients with estrogen receptor …
Involvement of the P2X7 receptor in the migration and metastasis of tamoxifen-resistant breast cancer: effects on small extracellular vesicles production.
Park M, Kim J, Phuong NTT, Park JG, Park JH, Kim YC, Baek MC, Lim SC, Kang KW. Park M, et al. Sci Rep. 2019 Aug 12;9(1):11587. doi: 10.1038/s41598-019-47734-z. Sci Rep. 2019. PMID: 31406126 Free PMC article.
Tamoxifen (TAM) is the standard anti-hormonal therapy for estrogen receptor-positive breast cancer. However, long-term TAM therapy can make acquisition of TAM resistance and there are still no solutions to treat TAM-resistant breast cancer. ...
Tamoxifen (TAM) is the standard anti-hormonal therapy for estrogen receptor-positive breast cancer. However, long-term TAM the …
Hepatic effects of long-term tamoxifen administration to cycling female rats.
Resende AD, Leal S, Batista-Pinto C, Garcez F, Sá SI. Resende AD, et al. J Biochem Mol Toxicol. 2019 May;33(5):e22293. doi: 10.1002/jbt.22293. Epub 2019 Jan 23. J Biochem Mol Toxicol. 2019. PMID: 30672060
The metabolic implications of tamoxifen (TAM) used as preventive therapy of young premenopausal women with high risk of breast cancer is unknown. To unravel this problem, an animal model of long-term TAM administration to cycling young adult female rats was used to …
The metabolic implications of tamoxifen (TAM) used as preventive therapy of young premenopausal women with high risk of breast cancer is unk …
Induction of GPR40 positively regulates cell motile and growth activities in breast cancer MCF-7 cells.
Fukushima K, Takahashi K, Kusaka M, Ishimoto K, Minami K, Otagaki S, Fukushima N, Honoki K, Tsujiuchi T. Fukushima K, et al. J Recept Signal Transduct Res. 2018 Aug;38(4):311-315. doi: 10.1080/10799893.2018.1494742. Epub 2018 Aug 15. J Recept Signal Transduct Res. 2018. PMID: 30111226
The expression level of GPR40 gene was markedly higher in the long-term TAM treated (MCF-TAM) cells than in MCF-7 cells. In cell motility assay, MCF-TAM cells indicated the high cell motile activity, compared with MCF-7 cells. ...These results suggest that the cell …
The expression level of GPR40 gene was markedly higher in the long-term TAM treated (MCF-TAM) cells than in MCF-7 cells. In ce …
ER-α36, a novel variant of ERα, is involved in the regulation of Tamoxifen-sensitivity of glioblastoma cells.
Liu Y, Huang L, Guan X, Li H, Zhang QQ, Han C, Wang YJ, Wang C, Zhang Y, Qu C, Liu J, Zou W. Liu Y, et al. Steroids. 2016 Jul;111:127-133. doi: 10.1016/j.steroids.2016.02.009. Epub 2016 Feb 18. Steroids. 2016. PMID: 26898538
Although accumulating evidence has confirmed that adjuvant Tamoxifen (TAM) treatment is able to sensitize glioblastoma cells to radiotherapy and inhibit their proliferation, TAM is not a suitable treatment for all types of glioblastoma cells; furthermore, long-term TAM …
Although accumulating evidence has confirmed that adjuvant Tamoxifen (TAM) treatment is able to sensitize glioblastoma cells to radiotherapy …
[Involvement of epidermal growth factor receptor signaling pathway in tamoxifen resistance of MCF-7 cells].
Zhen LL, Zhu X, Zheng W, Wang XY, Wu ZY. Zhen LL, et al. Ai Zheng. 2006 Jul;25(7):839-43. Ai Zheng. 2006. PMID: 16831274 Chinese.
CONCLUSION: In endocrine therapy, TAM resistant breast cancer cells are likely to be generated by the activation of EGFR signaling pathway after long-term TAM treatment, and EGFR inhibitors might increase the therapeutic effects in breast cancer treatment....
CONCLUSION: In endocrine therapy, TAM resistant breast cancer cells are likely to be generated by the activation of EGFR signaling pathway a …
Development of uterine sarcoma after tamoxifen treatment for breast cancer: report of four cases.
Yildirim Y, Inal MM, Sanci M, Yildirim YK, Mit T, Polat M, Tinar S. Yildirim Y, et al. Int J Gynecol Cancer. 2005 Nov-Dec;15(6):1239-42. doi: 10.1111/j.1525-1438.2005.00170.x. Int J Gynecol Cancer. 2005. PMID: 16343223
During the past 10 years, many descriptions of nonepithelial uterine malignancies related to long-term TAM usage have been reported in the literature. Four uterine sarcoma patients who had history of TAM usage for previous breast cancer are presented in this study. …
During the past 10 years, many descriptions of nonepithelial uterine malignancies related to long-term TAM usage have been rep …
Long-term exposure to tamoxifen induces hypersensitivity to estradiol.
Berstein LM, Wang JP, Zheng H, Yue W, Conaway M, Santen RJ. Berstein LM, et al. Clin Cancer Res. 2004 Feb 15;10(4):1530-4. doi: 10.1158/1078-0432.ccr-0433-03. Clin Cancer Res. 2004. PMID: 14977857
Oophorectomized nude mice with MCF-7 cell xenografts received 25-mg implants of TAM [long-term TAM treated (LTTT) mice] or cholesterol (C-MCF-7) over a 5-month period (phase 1). ...The LTTT tumors but not C-MCF-7 tumors exhibited a growth response on exposure to 20 …
Oophorectomized nude mice with MCF-7 cell xenografts received 25-mg implants of TAM [long-term TAM treated (LTTT) mice] or cho …
New approaches to the understanding of tamoxifen action and resistance.
Berstein LM, Zheng H, Yue W, Wang JP, Lykkesfeldt AE, Naftolin F, Harada H, Shanabrough M, Santen RJ. Berstein LM, et al. Endocr Relat Cancer. 2003 Jun;10(2):267-77. doi: 10.1677/erc.0.0100267. Endocr Relat Cancer. 2003. PMID: 12790788
Farnesylthiosalicylic acid (FTS), an inhibitor of GTP-Ras binding to its membrane acceptor site, reduces the increase in the number of MCF-7 cells induced by long-term TAM treatment. It also decreases MAPK activity in TAM-treated MCF-7 cells and in established TR ce …
Farnesylthiosalicylic acid (FTS), an inhibitor of GTP-Ras binding to its membrane acceptor site, reduces the increase in the number of MCF-7 …
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