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Protein translation in synaptic plasticity: mGluR-LTD, Fragile X.
Curr Opin Neurobiol. 2009 Jun;19(3):319-26. doi: 10.1016/j.conb.2009.03.011. Epub 2009 May 4.
Curr Opin Neurobiol. 2009.
PMID: 19411173
Free PMC article.
Review.
Studies of group 1 metabotropic glutamate receptor-dependent long-term depression (mGluR-LTD) have provided new insight into dendritic or local translation and plasticity. ...
Studies of group 1 metabotropic glutamate receptor-dependent long-term depression (mGluR-LTD) have provided new insight into dendriti …
Rapid translation of Arc/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate.
Waung MW, Pfeiffer BE, Nosyreva ED, Ronesi JA, Huber KM.
Waung MW, et al.
Neuron. 2008 Jul 10;59(1):84-97. doi: 10.1016/j.neuron.2008.05.014.
Neuron. 2008.
PMID: 18614031
Free PMC article.
Salient stimuli that modify behavior induce transcription of activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) and transport Arc mRNA into dendrites, suggesting that local Arc translation mediates synaptic plasticity that encodes such stimuli. Here, we demonstrate t …
Salient stimuli that modify behavior induce transcription of activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) and transport A …
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