Tumor factors stimulate lysosomal degradation of tumor antigens and undermine their cross-presentation in lung cancer.
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PMID: 36333297
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Accordingly, mice lacking CH25H in DCs exhibit an accelerated tumor growth, decreased infiltration and impaired activation of intratumoral CD8(+) T cells. These mice do not establish measurable long-term immunity against malignant cells that undergo chemotherapy-induced im …
Accordingly, mice lacking CH25H in DCs exhibit an accelerated tumor growth, decreased infiltration and impaired activation of intratumoral C …