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Page 1
Ferret Lung Transplantation Models Differential Lymphoid Aggregate Morphology Between Restrictive and Obstructive Forms of Chronic Lung Allograft Dysfunction.
Lynch TJ, Ahlers BA, Swatek AM, Ievlev V, Pai AC, Brooks L, Tang Y, Evans IA, Meyerholz DK, Engelhardt JF, Parekh KR. Lynch TJ, et al. Transplantation. 2022 Oct 1;106(10):1974-1989. doi: 10.1097/TP.0000000000004148. Epub 2022 Apr 15. Transplantation. 2022. PMID: 35442232 Free PMC article.
BACKGROUND: Long-term survival after lung transplantation remains limited by chronic lung allograft dysfunction (CLAD). ...
BACKGROUND: Long-term survival after lung transplantation remains limited by chronic lung allograft dysfunction (CLAD). ...
Quantitative Chest CT Assessment of Small Airways Disease in Post-Acute SARS-CoV-2 Infection.
Cho JL, Villacreses R, Nagpal P, Guo J, Pezzulo AA, Thurman AL, Hamzeh NY, Blount RJ, Fortis S, Hoffman EA, Zabner J, Comellas AP. Cho JL, et al. Radiology. 2022 Jul;304(1):185-192. doi: 10.1148/radiol.212170. Epub 2022 Mar 15. Radiology. 2022. PMID: 35289657 Free PMC article.
Background The long-term effects of SARS-CoV-2 infection on pulmonary structure and function remain incompletely characterized. ...Conclusion In survivors of COVID-19, small airways disease occurred independently of initial infection severity. The long-term conseque …
Background The long-term effects of SARS-CoV-2 infection on pulmonary structure and function remain incompletely characterized. ...Co …
Mitochondrial pyruvate carriers are required for myocardial stress adaptation.
Zhang Y, Taufalele PV, Cochran JD, Robillard-Frayne I, Marx JM, Soto J, Rauckhorst AJ, Tayyari F, Pewa AD, Gray LR, Teesch LM, Puchalska P, Funari TR, McGlauflin R, Zimmerman K, Kutschke WJ, Cassier T, Hitchcock S, Lin K, Kato KM, Stueve JL, Haff L, Weiss RM, Cox JE, Rutter J, Taylor EB, Crawford PA, Lewandowski ED, Des Rosiers C, Abel ED. Zhang Y, et al. Nat Metab. 2020 Nov;2(11):1248-1264. doi: 10.1038/s42255-020-00288-1. Epub 2020 Oct 26. Nat Metab. 2020. PMID: 33106689 Free PMC article.
Hypertrophied hearts accumulated lactate, pyruvate and glycogen, and displayed increased protein O-linked N-acetylglucosamine, which was prevented by increasing availability of non-glucose substrates in vivo by a ketogenic diet (KD) or a high-fat diet, which reversed the structur …
Hypertrophied hearts accumulated lactate, pyruvate and glycogen, and displayed increased protein O-linked N-acetylglucosamine, which was pre …
The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity.
Rauckhorst AJ, Gray LR, Sheldon RD, Fu X, Pewa AD, Feddersen CR, Dupuy AJ, Gibson-Corley KN, Cox JE, Burgess SC, Taylor EB. Rauckhorst AJ, et al. Mol Metab. 2017 Nov;6(11):1468-1479. doi: 10.1016/j.molmet.2017.09.002. Epub 2017 Sep 18. Mol Metab. 2017. PMID: 29107293 Free PMC article.
The goal of this investigation was to test whether hepatocyte MPC disruption provides sustained protection from hyperglycemia during long-term HFD and the differential effects of hepatocyte MPC disruption on TCA cycle metabolism in NCD versus HFD conditions. ...RESULTS: He …
The goal of this investigation was to test whether hepatocyte MPC disruption provides sustained protection from hyperglycemia during long- …
Hemoglobin A1c and C-reactive protein are independently associated with blunted nocturnal blood pressure dipping in obesity-related prediabetes.
Lane-Cordova AD, Kalil GZ, Wagner CJ, Sindler AL, Fiedorowicz JG, Ajibewa T, Haynes WG, Pierce GL. Lane-Cordova AD, et al. Hypertens Res. 2018 Jan;41(1):33-38. doi: 10.1038/hr.2017.82. Epub 2017 Oct 26. Hypertens Res. 2018. PMID: 29070829 Free PMC article.
However, nocturnal systolic BP dipping percent (P=0.65), CF-PWV (P=0.68) and CRP (P=0.59) were similar between participants with and without prediabetes. These data suggest that impaired long-term glycemic control and higher inflammation may contribute partly to blunted BP …
However, nocturnal systolic BP dipping percent (P=0.65), CF-PWV (P=0.68) and CRP (P=0.59) were similar between participants with and without …
Clinical and environmental influences on metabolic biomarkers collected for newborn screening.
Ryckman KK, Berberich SL, Shchelochkov OA, Cook DE, Murray JC. Ryckman KK, et al. Clin Biochem. 2013 Jan;46(1-2):133-8. doi: 10.1016/j.clinbiochem.2012.09.013. Epub 2012 Sep 23. Clin Biochem. 2013. PMID: 23010448 Free PMC article.
RESULTS: We replicated well known observations that low birth weight and preterm infants have higher essential amino acids and lower medium and long chain acylcarnitine levels than their term counterparts. ...CONCLUSIONS: We identified differences in metabolites by …
RESULTS: We replicated well known observations that low birth weight and preterm infants have higher essential amino acids and lower …
Replication of a genome-wide association study of birth weight in preterm neonates.
Ryckman KK, Feenstra B, Shaffer JR, Bream EN, Geller F, Feingold E, Weeks DE, Gadow E, Cosentino V, Saleme C, Simhan HN, Merrill D, Fong CT, Busch T, Berends SK, Comas B, Camelo JL, Boyd H, Laurie CC, Crosslin D, Zhang Q, Doheny KF, Pugh E, Melbye M, Marazita ML, Dagle JM, Murray JC. Ryckman KK, et al. J Pediatr. 2012 Jan;160(1):19-24.e4. doi: 10.1016/j.jpeds.2011.07.038. Epub 2011 Aug 31. J Pediatr. 2012. PMID: 21885063 Free PMC article.
OBJECTIVE: To examine associations between rs9883204 in ADCY5 and rs900400 near LEKR1 and CCNL1 with birth weight in a preterm population. Both markers were associated with birth weight in a term population in a recent genome-wide association study of Freathy …
OBJECTIVE: To examine associations between rs9883204 in ADCY5 and rs900400 near LEKR1 and CCNL1 with birth weight in a preterm popula …
Single-nucleotide polymorphisms in the KCNN3 gene associate with preterm birth.
Day LJ, Schaa KL, Ryckman KK, Cooper M, Dagle JM, Fong CT, Simhan HN, Merrill DC, Marazita ML, Murray JC, England SK. Day LJ, et al. Reprod Sci. 2011 Mar;18(3):286-95. doi: 10.1177/1933719110391277. Epub 2011 Jan 25. Reprod Sci. 2011. PMID: 21266667 Free PMC article.
The objectives were to determine whether single-nucleotide polymorphisms (SNPs) in KCNN3 (encodes the small conductance calcium-activated potassium channel subfamily N, member 3), associate with preterm birth (PTB). In all, 602 preterm families with at least 1 preterm (&lt …
The objectives were to determine whether single-nucleotide polymorphisms (SNPs) in KCNN3 (encodes the small conductance calcium-activated po …