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Evidence for in vitro extensive proliferation of adult hepatocytes and biliary epithelial cells.
Katsuda T, Sussman J, Li J, Merrell AJ, Vostrejs W, Secreto A, Matsuzaki J, Ochiya T, Stanger BZ. Katsuda T, et al. Stem Cell Reports. 2023 Jul 11;18(7):1436-1450. doi: 10.1016/j.stemcr.2023.05.016. Epub 2023 Jun 22. Stem Cell Reports. 2023. PMID: 37352852 Free PMC article.
Unexpectedly, we also found that the CLiP method allows biliary epithelial cells to acquire extensive proliferative capacity. Interestingly, after long-term culture, hepatocyte-derived cells (hepCLiPs) and biliary epithelial cell-derived cells (bilCLiPs) become similar in …
Unexpectedly, we also found that the CLiP method allows biliary epithelial cells to acquire extensive proliferative capacity. Interestingly, …
BetaScan2: Standardized Statistics to Detect Balancing Selection Utilizing Substitution Data.
Siewert KM, Voight BF. Siewert KM, et al. Genome Biol Evol. 2020 Feb 1;12(2):3873-3877. doi: 10.1093/gbe/evaa013. Genome Biol Evol. 2020. PMID: 32011695 Free PMC article.
Long-term balancing selection results in a build-up of alleles at similar frequencies and a deficit of substitutions when compared with an outgroup at a locus. ...
Long-term balancing selection results in a build-up of alleles at similar frequencies and a deficit of substitutions when compared wi …
Antiseptic Agents Elicit Short-Term, Personalized, and Body Site-Specific Shifts in Resident Skin Bacterial Communities.
SanMiguel AJ, Meisel JS, Horwinski J, Zheng Q, Bradley CW, Grice EA. SanMiguel AJ, et al. J Invest Dermatol. 2018 Oct;138(10):2234-2243. doi: 10.1016/j.jid.2018.04.022. Epub 2018 May 9. J Invest Dermatol. 2018. PMID: 29753031 Free PMC article.
Here we show that acute exposure to antiseptic treatments elicits rapid but short-term depletion of microbial community diversity and membership. Thirteen subjects were enrolled in a longitudinal treatment study to analyze the effects of topical treatments (i.e., ethanol, …
Here we show that acute exposure to antiseptic treatments elicits rapid but short-term depletion of microbial community diversity and …
Detecting Long-Term Balancing Selection Using Allele Frequency Correlation.
Siewert KM, Voight BF. Siewert KM, et al. Mol Biol Evol. 2017 Nov 1;34(11):2996-3005. doi: 10.1093/molbev/msx209. Mol Biol Evol. 2017. PMID: 28981714 Free PMC article.
Balancing selection occurs when multiple alleles are maintained in a population, which can result in their preservation over long evolutionary time periods. A characteristic signature of this long-term balancing selection is an excess number of intermediate frequency polym …
Balancing selection occurs when multiple alleles are maintained in a population, which can result in their preservation over long evolutiona …
Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance.
Shaffer SM, Dunagin MC, Torborg SR, Torre EA, Emert B, Krepler C, Beqiri M, Sproesser K, Brafford PA, Xiao M, Eggan E, Anastopoulos IN, Vargas-Garcia CA, Singh A, Nathanson KL, Herlyn M, Raj A. Shaffer SM, et al. Nature. 2017 Jun 15;546(7658):431-435. doi: 10.1038/nature22794. Epub 2017 Jun 7. Nature. 2017. PMID: 28607484 Free PMC article.
Therapies that target signalling molecules that are mutated in cancers can often have substantial short-term effects, but the emergence of resistant cancer cells is a major barrier to full cures. ...
Therapies that target signalling molecules that are mutated in cancers can often have substantial short-term effects, but the emergen …
Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability.
Nelson DM, Jaber-Hijazi F, Cole JJ, Robertson NA, Pawlikowski JS, Norris KT, Criscione SW, Pchelintsev NA, Piscitello D, Stong N, Rai TS, McBryan T, Otte GL, Nixon C, Clark W, Riethman H, Wu H, Schotta G, Garcia BA, Neretti N, Baird DM, Berger SL, Adams PD. Nelson DM, et al. Genome Biol. 2016 Jul 25;17(1):158. doi: 10.1186/s13059-016-1017-x. Genome Biol. 2016. PMID: 27457071 Free PMC article.
Rather, we speculate that H4K20me3 plays a role in heterochromatinization and stabilization of the epigenome and genome of pre-malignant, oncogene-expressing senescent cells, thereby suppressing epigenetic and genetic instability and contributing to long-term senescence-me …
Rather, we speculate that H4K20me3 plays a role in heterochromatinization and stabilization of the epigenome and genome of pre-malignant, on …
Overlapping cell population expression profiling and regulatory inference in C. elegans.
Burdick J, Walton T, Preston E, Zacharias A, Raj A, Murray JI. Burdick J, et al. BMC Genomics. 2016 Feb 29;17:159. doi: 10.1186/s12864-016-2482-z. BMC Genomics. 2016. PMID: 26926147 Free PMC article.
However, most cell types have not been assayed for expression genome-wide. RESULTS: We applied a novel approach we term "Profiling of Overlapping Populations of cells (POP-Seq)" to assay differential expression across all embryonic cells in the nematode Caenorhabditis eleg …
However, most cell types have not been assayed for expression genome-wide. RESULTS: We applied a novel approach we term "Profiling of …
Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism.
Oldridge DA, Wood AC, Weichert-Leahey N, Crimmins I, Sussman R, Winter C, McDaniel LD, Diamond M, Hart LS, Zhu S, Durbin AD, Abraham BJ, Anders L, Tian L, Zhang S, Wei JS, Khan J, Bramlett K, Rahman N, Capasso M, Iolascon A, Gerhard DS, Guidry Auvil JM, Young RA, Hakonarson H, Diskin SJ, Look AT, Maris JM. Oldridge DA, et al. Nature. 2015 Dec 17;528(7582):418-21. doi: 10.1038/nature15540. Epub 2015 Nov 11. Nature. 2015. PMID: 26560027 Free PMC article.
Clinical phenotypes range from localized tumours with excellent outcomes to widely metastatic disease in which long-term survival is approximately 40% despite intensive therapy. A previous genome-wide association study identified common polymorphisms at the LMO1 gene locus …
Clinical phenotypes range from localized tumours with excellent outcomes to widely metastatic disease in which long-term survival is …
Placental expression of miR-517a/b and miR-517c contributes to trophoblast dysfunction and preeclampsia.
Anton L, Olarerin-George AO, Hogenesch JB, Elovitz MA. Anton L, et al. PLoS One. 2015 Mar 23;10(3):e0122707. doi: 10.1371/journal.pone.0122707. eCollection 2015. PLoS One. 2015. PMID: 25799546 Free PMC article.
Using placental biopsies from a preeclampsia case-control study, we found increased expression of miR-517a/b in term and preterm preeclampsia vs controls, while, miR-517c was increased only in preterm preeclampsia vs controls. ...
Using placental biopsies from a preeclampsia case-control study, we found increased expression of miR-517a/b in term and preterm pree …
Host sequence motifs shared by HIV predict response to antiretroviral therapy.
Dampier W, Evans P, Ungar L, Tozeren A. Dampier W, et al. BMC Med Genomics. 2009 Jul 23;2:47. doi: 10.1186/1755-8794-2-47. BMC Med Genomics. 2009. PMID: 19627600 Free PMC article.
BACKGROUND: The HIV viral genome mutates at a high rate and poses a significant long term health risk even in the presence of combination antiretroviral therapy. ...
BACKGROUND: The HIV viral genome mutates at a high rate and poses a significant long term health risk even in the presence of combina …