Gravin orchestrates protein kinase A and β2-adrenergic receptor signaling critical for synaptic plasticity and memory.
Havekes R, Canton DA, Park AJ, Huang T, Nie T, Day JP, Guercio LA, Grimes Q, Luczak V, Gelman IH, Baillie GS, Scott JD, Abel T.
Havekes R, et al.
J Neurosci. 2012 Dec 12;32(50):18137-49. doi: 10.1523/JNEUROSCI.3612-12.2012.
J Neurosci. 2012.
PMID: 23238728
Free PMC article.
Here, we show that mice lacking the alpha-isoform of gravin have deficits in PKA-dependent long-lasting forms of hippocampal synaptic plasticity including beta2-adrenergic receptor-mediated plasticity, and selective impairments of long-term memory storage. Furthermore, bot …
Here, we show that mice lacking the alpha-isoform of gravin have deficits in PKA-dependent long-lasting forms of hippocampal synaptic plasti …