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Skin-penetrating nematodes exhibit life-stage-specific interactions with host-associated and environmental bacteria.
Chavez IN, Brown TM, Assié A, Bryant AS, Samuel BS, Hallem EA. Chavez IN, et al. BMC Biol. 2021 Oct 7;19(1):221. doi: 10.1186/s12915-021-01153-7. BMC Biol. 2021. PMID: 34620172 Free PMC article.
The behavioral responses to bacteria were dynamic, consisting of distinct short- and long-term behaviors. Finally, a comparison of the growth and reproduction of S. stercoralis free-living adults on different bacteria revealed that the bacterium Proteus mirabilis inhibits …
The behavioral responses to bacteria were dynamic, consisting of distinct short- and long-term behaviors. Finally, a comparison of th …
Stable retention of chloramphenicol-resistant mtDNA to rescue metabolically impaired cells.
Dawson ER, Patananan AN, Sercel AJ, Teitell MA. Dawson ER, et al. Sci Rep. 2020 Aug 31;10(1):14328. doi: 10.1038/s41598-020-71199-0. Sci Rep. 2020. PMID: 32868785 Free PMC article.
Previous studies documented multiple biochemical changes in recipient cells shortly after mtDNA transfer, but the long-term retention and function of transferred mtDNA remains unknown. ...
Previous studies documented multiple biochemical changes in recipient cells shortly after mtDNA transfer, but the long-term retention …
Intragenic suppressor mutations of the COQ8 protein kinase homolog restore coenzyme Q biosynthesis and function in Saccharomyces cerevisiae.
Awad AM, Nag A, Pham NVB, Bradley MC, Jabassini N, Nathaniel J, Clarke CF. Awad AM, et al. PLoS One. 2020 Jun 1;15(6):e0234192. doi: 10.1371/journal.pone.0234192. eCollection 2020. PLoS One. 2020. PMID: 32479562 Free PMC article.
The A197V substitution occurs in the crucial Ala-rich protein kinase-like motif I of yeast Coq8. Here we show that long-term cultures of mutants expressing Coq8-A197V produce spontaneous revertants with the ability to grow on medium containing a non-fermentable carbon sour …
The A197V substitution occurs in the crucial Ala-rich protein kinase-like motif I of yeast Coq8. Here we show that long-term cultures …
Leukocyte Lysis and Cytokine Induction by the Human Sexually Transmitted Parasite Trichomonas vaginalis.
Mercer F, Diala FG, Chen YP, Molgora BM, Ng SH, Johnson PJ. Mercer F, et al. PLoS Negl Trop Dis. 2016 Aug 16;10(8):e0004913. doi: 10.1371/journal.pntd.0004913. eCollection 2016 Aug. PLoS Negl Trop Dis. 2016. PMID: 27529696 Free PMC article.
While acute symptoms in women may include vaginitis, infections are often asymptomatic, but can persist and are associated with medical complications including increased HIV susceptibility, infertility, pre-term labor, and higher incidence of cervical cancer. Heightened in …
While acute symptoms in women may include vaginitis, infections are often asymptomatic, but can persist and are associated with medical comp …
Structure of the toxic core of α-synuclein from invisible crystals.
Rodriguez JA, Ivanova MI, Sawaya MR, Cascio D, Reyes FE, Shi D, Sangwan S, Guenther EL, Johnson LM, Zhang M, Jiang L, Arbing MA, Nannenga BL, Hattne J, Whitelegge J, Brewster AS, Messerschmidt M, Boutet S, Sauter NK, Gonen T, Eisenberg DS. Rodriguez JA, et al. Nature. 2015 Sep 24;525(7570):486-90. doi: 10.1038/nature15368. Epub 2015 Sep 9. Nature. 2015. PMID: 26352473 Free PMC article.
The protein alpha-synuclein is the main component of Lewy bodies, the neuron-associated aggregates seen in Parkinson disease and other neurodegenerative pathologies. An 11-residue segment, which we term NACore, appears to be responsible for amyloid formation and cytotoxici …
The protein alpha-synuclein is the main component of Lewy bodies, the neuron-associated aggregates seen in Parkinson disease and other neuro …
Patterns of growth and tract formation during the early development of secondary lineages in the Drosophila larval brain.
Lovick JK, Kong A, Omoto JJ, Ngo KT, Younossi-Hartenstein A, Hartenstein V. Lovick JK, et al. Dev Neurobiol. 2016 Apr;76(4):434-51. doi: 10.1002/dneu.22325. Epub 2015 Jul 28. Dev Neurobiol. 2016. PMID: 26178322 Free PMC article.
The Drosophila brain consists of a relatively small number of invariant, genetically determined lineages which provide a model to study the relationship between gene function and neuronal architecture. In following this long-term goal, we reconstruct the morphology (projec …
The Drosophila brain consists of a relatively small number of invariant, genetically determined lineages which provide a model to study the …
The human ankyrin 1 promoter insulator sustains gene expression in a β-globin lentiviral vector in hematopoietic stem cells.
Romero Z, Campo-Fernandez B, Wherley J, Kaufman ML, Urbinati F, Cooper AR, Hoban MD, Baldwin KM, Lumaquin D, Wang X, Senadheera S, Hollis RP, Kohn DB. Romero Z, et al. Mol Ther Methods Clin Dev. 2015 Apr 22;2:15012. doi: 10.1038/mtm.2015.12. eCollection 2015. Mol Ther Methods Clin Dev. 2015. PMID: 26029723 Free PMC article.
The presence of the Ankyrin insulator element did not change transgene expression in human hematopoietic cells in short-term erythroid culture or in vivo in primary murine transplants. ...These studies demonstrate that the Ankyrin insulator may improve long-term bet …
The presence of the Ankyrin insulator element did not change transgene expression in human hematopoietic cells in short-term erythroi …
Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN1.
Ting PY, Damoiseaux R, Titz B, Bradley KA, Graeber TG, Fernández-Vega V, Bannister TD, Chase P, Nair R, Scampavia L, Hodder P, Spicer TP, Colicelli J. Ting PY, et al. PLoS One. 2015 Mar 26;10(3):e0121833. doi: 10.1371/journal.pone.0121833. eCollection 2015. PLoS One. 2015. PMID: 25811598 Free PMC article.
Although these fusions have been successfully targeted with kinase inhibitors, drug-resistance and relapse continue to limit long-term survival, highlighting the need for continued innovative drug discovery. ...
Although these fusions have been successfully targeted with kinase inhibitors, drug-resistance and relapse continue to limit long-term …
Enrichment of human hematopoietic stem/progenitor cells facilitates transduction for stem cell gene therapy.
Baldwin K, Urbinati F, Romero Z, Campo-Fernandez B, Kaufman ML, Cooper AR, Masiuk K, Hollis RP, Kohn DB. Baldwin K, et al. Stem Cells. 2015 May;33(5):1532-42. doi: 10.1002/stem.1957. Stem Cells. 2015. PMID: 25588820 Free PMC article.
Isolated CD34(+) /CD38(-) cells were able to generate progeny over an extended period of long-term culture (LTC) compared to the CD34(+) cells and required up to 40-fold less vector for transduction compared to bulk CD34(+) preparations containing an equivalent number of C …
Isolated CD34(+) /CD38(-) cells were able to generate progeny over an extended period of long-term culture (LTC) compared to the CD34 …
Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice.
Ramos E, Kautz L, Rodriguez R, Hansen M, Gabayan V, Ginzburg Y, Roth MP, Nemeth E, Ganz T. Ramos E, et al. Hepatology. 2011 Apr;53(4):1333-41. doi: 10.1002/hep.24178. Hepatology. 2011. PMID: 21480335 Free PMC article.
To understand the role each of these proteins plays in hepcidin regulation by iron, we analyzed hepcidin messenger RNA (mRNA) responsiveness to short and long-term iron challenge in iron-depleted Hfe, Tfr2, Hjv, and Bmp6 mutant mice. ...
To understand the role each of these proteins plays in hepcidin regulation by iron, we analyzed hepcidin messenger RNA (mRNA) responsiveness …
16 results