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Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis.
Wong JC, Weinfurtner KM, Alzamora Mdel P, Kogan SC, Burgess MR, Zhang Y, Nakitandwe J, Ma J, Cheng J, Chen SC, Ho TT, Flach J, Reynaud D, Passegué E, Downing JR, Shannon K. Wong JC, et al. Elife. 2015 Jul 20;4:e07839. doi: 10.7554/eLife.07839. Elife. 2015. PMID: 26193121 Free PMC article.
We generated mice with a heterozygous germ line deletion of a 2-Mb interval of chromosome band 5A3 syntenic to a commonly deleted segment of human 7q22 and show that mutant hematopoietic cells exhibit cardinal features of MDS. Specifically, the long-term hematopoietic stem …
We generated mice with a heterozygous germ line deletion of a 2-Mb interval of chromosome band 5A3 syntenic to a commonly deleted segment of …
Oncogene mimicry as a mechanism of primary resistance to BRAF inhibitors.
Sos ML, Levin RS, Gordan JD, Oses-Prieto JA, Webber JT, Salt M, Hann B, Burlingame AL, McCormick F, Bandyopadhyay S, Shokat KM. Sos ML, et al. Cell Rep. 2014 Aug 21;8(4):1037-48. doi: 10.1016/j.celrep.2014.07.010. Epub 2014 Aug 7. Cell Rep. 2014. PMID: 25127139 Free PMC article.
Overall, we show that the signaling plasticity exerted by primary resistant BRAF-mutant cells is achieved by their ability to mimic signaling features of oncogenic RAS, a strategy that we term "oncogene mimicry." This model may guide future strategies for overcoming primar …
Overall, we show that the signaling plasticity exerted by primary resistant BRAF-mutant cells is achieved by their ability to mimic signalin …
Graduate education. Interdisciplinary graduate training in teaching labs.
Vale RD, DeRisi J, Phillips R, Mullins RD, Waterman C, Mitchison TJ. Vale RD, et al. Science. 2012 Dec 21;338(6114):1542-3. doi: 10.1126/science.1216570. Science. 2012. PMID: 23258877 Free PMC article.
Intensive, short-term courses meld students and faculty and new techniques in pursuit of genuine research questions....
Intensive, short-term courses meld students and faculty and new techniques in pursuit of genuine research questions....