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2012 | 1 |
2014 | 1 |
2015 | 1 |
2024 | 0 |
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Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis.
Elife. 2015 Jul 20;4:e07839. doi: 10.7554/eLife.07839.
Elife. 2015.
PMID: 26193121
Free PMC article.
We generated mice with a heterozygous germ line deletion of a 2-Mb interval of chromosome band 5A3 syntenic to a commonly deleted segment of human 7q22 and show that mutant hematopoietic cells exhibit cardinal features of MDS. Specifically, the long-term hematopoietic stem …
We generated mice with a heterozygous germ line deletion of a 2-Mb interval of chromosome band 5A3 syntenic to a commonly deleted segment of …
Oncogene mimicry as a mechanism of primary resistance to BRAF inhibitors.
Sos ML, Levin RS, Gordan JD, Oses-Prieto JA, Webber JT, Salt M, Hann B, Burlingame AL, McCormick F, Bandyopadhyay S, Shokat KM.
Sos ML, et al.
Cell Rep. 2014 Aug 21;8(4):1037-48. doi: 10.1016/j.celrep.2014.07.010. Epub 2014 Aug 7.
Cell Rep. 2014.
PMID: 25127139
Free PMC article.
Overall, we show that the signaling plasticity exerted by primary resistant BRAF-mutant cells is achieved by their ability to mimic signaling features of oncogenic RAS, a strategy that we term "oncogene mimicry." This model may guide future strategies for overcoming primar …
Overall, we show that the signaling plasticity exerted by primary resistant BRAF-mutant cells is achieved by their ability to mimic signalin …
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Graduate education. Interdisciplinary graduate training in teaching labs.
Vale RD, DeRisi J, Phillips R, Mullins RD, Waterman C, Mitchison TJ.
Vale RD, et al.
Science. 2012 Dec 21;338(6114):1542-3. doi: 10.1126/science.1216570.
Science. 2012.
PMID: 23258877
Free PMC article.
Intensive, short-term courses meld students and faculty and new techniques in pursuit of genuine research questions....
Intensive, short-term courses meld students and faculty and new techniques in pursuit of genuine research questions....
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