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Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4+ T cell identity and function.
Basu J, Reis BS, Peri S, Zha J, Hua X, Ge L, Ferchen K, Nicolas E, Czyzewicz P, Cai KQ, Tan Y, Fuxman Bass JI, Walhout AJM, Grimes HL, Grivennikov SI, Mucida D, Kappes DJ. Basu J, et al. Nat Immunol. 2021 Aug;22(8):969-982. doi: 10.1038/s41590-021-00980-8. Epub 2021 Jul 26. Nat Immunol. 2021. PMID: 34312548 Free PMC article.
In the present study, we describe a new autoregulatory loop whereby ThPOK binds to the Sil(ThPOK) to maintain its own long-term expression in CD4 T cells. Disruption of this loop in vivo prevents persistent ThPOK expression, leads to genome-wide changes in chromatin access …
In the present study, we describe a new autoregulatory loop whereby ThPOK binds to the Sil(ThPOK) to maintain its own long-term expre …
Tobacco smoking induces metabolic reprogramming of renal cell carcinoma.
Reigle J, Secic D, Biesiada J, Wetzel C, Shamsaei B, Chu J, Zang Y, Zhang X, Talbot NJ, Bischoff ME, Zhang Y, Thakar CV, Gaitonde K, Sidana A, Bui H, Cunningham JT, Zhang Q, Schmidt LS, Linehan WM, Medvedovic M, Plas DR, Figueroa JAL, Meller J, Czyzyk-Krzeska MF. Reigle J, et al. J Clin Invest. 2021 Jan 4;131(1):e140522. doi: 10.1172/JCI140522. J Clin Invest. 2021. PMID: 32970633 Free PMC article.
Tobacco smoking (TS) is an established risk factor for ccRCC, with unknown effects on tumor pathobiology.METHODSWe investigated the landscape of ccRCCs and paired normal kidney tissues using integrated transcriptomic, metabolomic, and metallomic approaches in a cohort of white ma …
Tobacco smoking (TS) is an established risk factor for ccRCC, with unknown effects on tumor pathobiology.METHODSWe investigated the landscap …
MST1R (RON) expression is a novel prognostic biomarker for metastatic progression in breast cancer patients.
Hunt BG, Wicker CA, Bourn JR, Lower EE, Takiar V, Waltz SE. Hunt BG, et al. Breast Cancer Res Treat. 2020 Jun;181(3):529-540. doi: 10.1007/s10549-020-05653-y. Epub 2020 Apr 27. Breast Cancer Res Treat. 2020. PMID: 32342233 Free PMC article.
PURPOSE: This study evaluates the prognostic significance of MST1R (RON) expression in breast cancer with respect to disease progression, long-term survival, subtype, and association with conventional prognostic factors. ...
PURPOSE: This study evaluates the prognostic significance of MST1R (RON) expression in breast cancer with respect to disease progression, lo …
Towards increasing shelf life and haemostatic potency of stored platelet concentrates.
Hegde S, Akbar H, Zheng Y, Cancelas JA. Hegde S, et al. Curr Opin Hematol. 2018 Nov;25(6):500-508. doi: 10.1097/MOH.0000000000000456. Curr Opin Hematol. 2018. PMID: 30281037 Free PMC article. Review.
It is anticipated that future platelet preservation involving cold, frozen and/or pathogen reduction strategies in a proper platelet additive solution will enable longer term and safer platelet storage....
It is anticipated that future platelet preservation involving cold, frozen and/or pathogen reduction strategies in a proper platelet additiv …
Supraphysiologic levels of the AML1-ETO isoform AE9a are essential for transformation.
Link KA, Lin S, Shrestha M, Bowman M, Wunderlich M, Bloomfield CD, Huang G, Mulloy JC. Link KA, et al. Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):9075-80. doi: 10.1073/pnas.1524225113. Epub 2016 Jul 25. Proc Natl Acad Sci U S A. 2016. PMID: 27457952 Free PMC article.
The resultant in-frame fusion protein AML1-ETO (AE) acts as an initiating oncogene for leukemia development. AE immortalizes human CD34(+) cord blood cells in long-term culture. We assessed the transforming properties of the alternatively spliced AE isoform AE9a (or altern …
The resultant in-frame fusion protein AML1-ETO (AE) acts as an initiating oncogene for leukemia development. AE immortalizes human CD34(+) c …
p62 is required for stem cell/progenitor retention through inhibition of IKK/NF-κB/Ccl4 signaling at the bone marrow macrophage-osteoblast niche.
Chang KH, Sengupta A, Nayak RC, Duran A, Lee SJ, Pratt RG, Wellendorf AM, Hill SE, Watkins M, Gonzalez-Nieto D, Aronow BJ, Starczynowski DT, Civitelli R, Diaz-Meco MT, Moscat J, Cancelas JA. Chang KH, et al. Cell Rep. 2014 Dec 24;9(6):2084-97. doi: 10.1016/j.celrep.2014.11.031. Epub 2014 Dec 18. Cell Rep. 2014. PMID: 25533346 Free PMC article.
Consequently, Ob p62-deficient mice lose bone, Ob Ccl4 expression, and HP chemotaxis toward Cxcl12, resulting in egress of short-term hematopoietic stem cells and myeloid progenitors. Finally, Ccl4 expression and myeloid progenitor egress are reversed by deficiency of the …
Consequently, Ob p62-deficient mice lose bone, Ob Ccl4 expression, and HP chemotaxis toward Cxcl12, resulting in egress of short-term …
Sphere culture of murine lung cancer cell lines are enriched with cancer initiating cells.
Morrison BJ, Steel JC, Morris JC. Morrison BJ, et al. PLoS One. 2012;7(11):e49752. doi: 10.1371/journal.pone.0049752. Epub 2012 Nov 13. PLoS One. 2012. PMID: 23152931 Free PMC article.
However, in tumorsphere culture, these cells exhibited self-renewal and long-term symmetric division capacity and expressed more Oct-4 compared to adherent cells. ...
However, in tumorsphere culture, these cells exhibited self-renewal and long-term symmetric division capacity and expressed more Oct- …
Ron receptor tyrosine kinase signaling as a therapeutic target.
Benight NM, Waltz SE. Benight NM, et al. Expert Opin Ther Targets. 2012 Sep;16(9):921-31. doi: 10.1517/14728222.2012.710200. Epub 2012 Jul 26. Expert Opin Ther Targets. 2012. PMID: 22834780 Free PMC article. Review.
Additional studies of targeted therapies, either alone or in conjunction with current therapies are needed to determine if inhibition of Ron signaling will provide long-term benefits to cancer patients....
Additional studies of targeted therapies, either alone or in conjunction with current therapies are needed to determine if inhibition of Ron …
The retinoblastoma tumor suppressor modifies the therapeutic response of breast cancer.
Bosco EE, Wang Y, Xu H, Zilfou JT, Knudsen KE, Aronow BJ, Lowe SW, Knudsen ES. Bosco EE, et al. J Clin Invest. 2007 Jan;117(1):218-28. doi: 10.1172/JCI28803. Epub 2006 Dec 7. J Clin Invest. 2007. PMID: 17160137 Free PMC article.
RB knockdown resulted in RB/E2F target gene deregulation and accelerated tumorigenic proliferation, thereby demonstrating that even in the context of a complex tumor cell genome, RB status exerts significant control over proliferation. Furthermore, the RB deficiency compromised t …
RB knockdown resulted in RB/E2F target gene deregulation and accelerated tumorigenic proliferation, thereby demonstrating that even in the c …