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Page 1
Circulating Tumor DNA Analysis to Assess Risk of Progression after Long-term Response to PD-(L)1 Blockade in NSCLC.
Hellmann MD, Nabet BY, Rizvi H, Chaudhuri AA, Wells DK, Dunphy MPS, Chabon JJ, Liu CL, Hui AB, Arbour KC, Luo J, Preeshagul IR, Moding EJ, Almanza D, Bonilla RF, Sauter JL, Choi H, Tenet M, Abu-Akeel M, Plodkowski AJ, Perez Johnston R, Yoo CH, Ko RB, Stehr H, Gojenola L, Wakelee HA, Padda SK, Neal JW, Chaft JE, Kris MG, Rudin CM, Merghoub T, Li BT, Alizadeh AA, Diehn M. Hellmann MD, et al. Clin Cancer Res. 2020 Jun 15;26(12):2849-2858. doi: 10.1158/1078-0432.CCR-19-3418. Epub 2020 Feb 11. Clin Cancer Res. 2020. PMID: 32046999 Free PMC article.
We hypothesized that circulating tumor DNA (ctDNA) analysis of long-term responders to PD-(L)1 blockade may differentiate those who will achieve ongoing benefit from those at risk of eventual progression. ...CONCLUSIONS: ctDNA analysis can noninvasively identify minimal re …
We hypothesized that circulating tumor DNA (ctDNA) analysis of long-term responders to PD-(L)1 blockade may differentiate those who w …
Genomic stability at the coding regions of the multidrug transporter gene ABCB1: insights into the development of alternative drug resistance mechanisms in human leukemia cells.
Chen KG, Duran GE, Mogul MJ, Wang YC, Ross KL, Jaffrézou JP, Huff LM, Johnson KR, Fojo T, Lacayo NJ, Sikic BI. Chen KG, et al. Cancer Drug Resist. 2020;3(4):959-979. doi: 10.20517/cdr.2020.51. Epub 2020 Nov 3. Cancer Drug Resist. 2020. PMID: 34541464 Free PMC article.
Strikingly, no mutations were found in the ABCB1 coding regions in these variant cells even under long-term stringent drug selection. Genomically, ABCB1 displayed relatively low variant allele frequencies in human populations when compared with several ABC superfamily memb …
Strikingly, no mutations were found in the ABCB1 coding regions in these variant cells even under long-term stringent drug selection. …
Neogenin-1 distinguishes between myeloid-biased and balanced Hoxb5(+) mouse long-term hematopoietic stem cells.
Gulati GS, Zukowska M, Noh JJ, Zhang A, Wesche DJ, Sinha R, George BM, Weissman IL, Szade K. Gulati GS, et al. Proc Natl Acad Sci U S A. 2019 Dec 10;116(50):25115-25125. doi: 10.1073/pnas.1911024116. Epub 2019 Nov 21. Proc Natl Acad Sci U S A. 2019. PMID: 31754028 Free PMC article.
Here, we identify Neogenin-1 (NEO1) as a unique surface marker on a fraction of mouse HSCs labeled with Hoxb5, a specific reporter of long-term HSCs (LT-HSCs). We show that NEO1(+)Hoxb5(+) LT-HSCs expand with age and respond to myeloablative stress in young mice while NEO1 …
Here, we identify Neogenin-1 (NEO1) as a unique surface marker on a fraction of mouse HSCs labeled with Hoxb5, a specific reporter of long- …
The African turquoise killifish: A research organism to study vertebrate aging and diapause.
Hu CK, Brunet A. Hu CK, et al. Aging Cell. 2018 Jun;17(3):e12757. doi: 10.1111/acel.12757. Epub 2018 Mar 24. Aging Cell. 2018. PMID: 29573324 Free PMC article. Review.
Interestingly, the turquoise killifish can also enter a long-term dormant state during development called diapause. Killifish embryos in diapause already have some organs and tissues, and they can last in this state for years, exhibiting exceptional resistance to stress an …
Interestingly, the turquoise killifish can also enter a long-term dormant state during development called diapause. Killifish embryos …
Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells.
Mou H, Vinarsky V, Tata PR, Brazauskas K, Choi SH, Crooke AK, Zhang B, Solomon GM, Turner B, Bihler H, Harrington J, Lapey A, Channick C, Keyes C, Freund A, Artandi S, Mense M, Rowe S, Engelhardt JF, Hsu YC, Rajagopal J. Mou H, et al. Cell Stem Cell. 2016 Aug 4;19(2):217-231. doi: 10.1016/j.stem.2016.05.012. Epub 2016 Jun 16. Cell Stem Cell. 2016. PMID: 27320041 Free PMC article.
Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia.
Chao MP, Alizadeh AA, Tang C, Jan M, Weissman-Tsukamoto R, Zhao F, Park CY, Weissman IL, Majeti R. Chao MP, et al. Cancer Res. 2011 Feb 15;71(4):1374-84. doi: 10.1158/0008-5472.CAN-10-2238. Epub 2010 Dec 21. Cancer Res. 2011. PMID: 21177380 Free PMC article.
Multiagent chemotherapy is standard of care for both pediatric and adult ALL, but is associated with systemic toxicity and long-term side effects and is relatively ineffective against certain ALL subtypes. ...
Multiagent chemotherapy is standard of care for both pediatric and adult ALL, but is associated with systemic toxicity and long-term …
Impact of hydrodynamic injection and phiC31 integrase on tumor latency in a mouse model of MYC-induced hepatocellular carcinoma.
Woodard LE, Keravala A, Jung WE, Wapinski OL, Yang Q, Felsher DW, Calos MP. Woodard LE, et al. PLoS One. 2010 Jun 29;5(6):e11367. doi: 10.1371/journal.pone.0011367. PLoS One. 2010. PMID: 20614008 Free PMC article.
Similarly, phiC31 integrase has proven effective in mediating long-term gene therapy in mice when delivered by hydrodynamic injection and is being considered for clinical gene therapy applications. ...METHODOLOGY/PRINCIPAL FINDINGS: To study whether hydrodynamic delivery a …
Similarly, phiC31 integrase has proven effective in mediating long-term gene therapy in mice when delivered by hydrodynamic injection …
Kinetics and longevity of ΦC31 integrase in mouse liver and cultured cells.
Chavez CL, Keravala A, Woodard LE, Hillman RT, Stowe TR, Chu JN, Calos MP. Chavez CL, et al. Hum Gene Ther. 2010 Oct;21(10):1287-97. doi: 10.1089/hum.2010.049. Hum Gene Ther. 2010. PMID: 20497035 Free PMC article.
For example, the phiC31 system has been used in combination with hydrodynamic injection to achieve long-term expression of factor IX in mouse liver. However, a concern is that prolonged expression of phiC31 integrase within cells could potentially stimulate chromosome rear …
For example, the phiC31 system has been used in combination with hydrodynamic injection to achieve long-term expression of factor IX …
Mutational derivatives of PhiC31 integrase with increased efficiency and specificity.
Keravala A, Lee S, Thyagarajan B, Olivares EC, Gabrovsky VE, Woodard LE, Calos MP. Keravala A, et al. Mol Ther. 2009 Jan;17(1):112-20. doi: 10.1038/mt.2008.241. Epub 2008 Nov 11. Mol Ther. 2009. PMID: 19002165 Free PMC article.
In mouse liver, P2-mediated integration provided therapeutic long-term levels of human factor IX that were double those generated by wild-type phiC31 integrase. ...
In mouse liver, P2-mediated integration provided therapeutic long-term levels of human factor IX that were double those generated by …