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Optimizing animal models of autoimmune encephalitis using active immunization.
Linnoila J, Jalali Motlagh N, Jachimiec G, Lin CJ, Küllenberg E, Wojtkiewicz G, Tanzi R, Chen JW. Linnoila J, et al. Front Immunol. 2023 Jul 12;14:1177672. doi: 10.3389/fimmu.2023.1177672. eCollection 2023. Front Immunol. 2023. PMID: 37520559 Free PMC article.
A novel ventrally-induced NMDARE model demonstrated characteristics of AE earlier compared to dorsally-induced animals and is likely suitable for most short-term studies. However, boosting and improving the durability of the immune response might be preferred in prolonged …
A novel ventrally-induced NMDARE model demonstrated characteristics of AE earlier compared to dorsally-induced animals and is likely suitabl …
Longitudinal Modeling of Depressive Trajectories Among HIV-Infected Men Using Cocaine.
Mukerji S, Haghighat R, Misra V, Lorenz DR, Holman A, Dutta A, Gabuzda D. Mukerji S, et al. AIDS Behav. 2017 Jul;21(7):1985-1995. doi: 10.1007/s10461-017-1801-y. AIDS Behav. 2017. PMID: 28550378 Free PMC article.
While cross-sectional studies suggest that cocaine users may be at increased risk for depression, long-term effects of cocaine on depressive symptoms remain unclear. This is a longitudinal study of 341 HIV-infected and uninfected men (135 cocaine users and 206 controls) ag …
While cross-sectional studies suggest that cocaine users may be at increased risk for depression, long-term effects of cocaine on dep …
Long-term nitrite inhalant exposure and cancer risk in MSM.
Dutta A, Uno H, Holman A, Lorenz DR, Wolinsky SM, Gabuzda D. Dutta A, et al. AIDS. 2017 May 15;31(8):1169-1180. doi: 10.1097/QAD.0000000000001451. AIDS. 2017. PMID: 28441176 Free PMC article.
OBJECTIVES: Nitrite inhalants (poppers) are commonly used recreational drugs among MSM and were previously associated with elevated rates of high-risk sexual behavior, HIV and human herpesvirus type 8 (HHV-8) seroconversion, and transient immunosuppressive effects in experimental …
OBJECTIVES: Nitrite inhalants (poppers) are commonly used recreational drugs among MSM and were previously associated with elevated rates of …
Complement and microglia mediate early synapse loss in Alzheimer mouse models.
Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li S, Ramakrishnan S, Merry KM, Shi Q, Rosenthal A, Barres BA, Lemere CA, Selkoe DJ, Stevens B. Hong S, et al. Science. 2016 May 6;352(6286):712-716. doi: 10.1126/science.aad8373. Epub 2016 Mar 31. Science. 2016. PMID: 27033548 Free PMC article.
C1q is necessary for the toxic effects of soluble beta-amyloid (Abeta) oligomers on synapses and hippocampal long-term potentiation. Finally, microglia in adult brains engulf synaptic material in a CR3-dependent process when exposed to soluble Abeta oligomers. ...
C1q is necessary for the toxic effects of soluble beta-amyloid (Abeta) oligomers on synapses and hippocampal long-term potentiation. …
Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats.
Hargus G, Cooper O, Deleidi M, Levy A, Lee K, Marlow E, Yow A, Soldner F, Hockemeyer D, Hallett PJ, Osborn T, Jaenisch R, Isacson O. Hargus G, et al. Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15921-6. doi: 10.1073/pnas.1010209107. Epub 2010 Aug 23. Proc Natl Acad Sci U S A. 2010. PMID: 20798034 Free PMC article.
Such findings establish the transplantation of human PDiPS cell-derived neurons as a long-term in vivo method to analyze potential disease-related changes in a physiological context. ...
Such findings establish the transplantation of human PDiPS cell-derived neurons as a long-term in vivo method to analyze potential di …