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Evaluating the real-world implementation of the Family Nurse Partnership in England: protocol for a data linkage study.
Cavallaro FL, Gilbert R, Wijlaars L, Kennedy E, Swarbrick A, van der Meulen J, Harron K. Cavallaro FL, et al. Among authors: swarbrick a. BMJ Open. 2020 May 18;10(5):e038530. doi: 10.1136/bmjopen-2020-038530. BMJ Open. 2020. PMID: 32430455 Free PMC article.
However, a randomised controlled trial in England found no effect on short-term primary outcomes, although cognitive development up to age 2 showed improvement. ...METHODS AND ANALYSIS: We will construct a retrospective cohort of all women aged 13-24 years giving birth …
However, a randomised controlled trial in England found no effect on short-term primary outcomes, although cognitive development up t …
Prostate cancer cell-intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone.
Owen KL, Gearing LJ, Zanker DJ, Brockwell NK, Khoo WH, Roden DL, Cmero M, Mangiola S, Hong MK, Spurling AJ, McDonald M, Chan CL, Pasam A, Lyons RJ, Duivenvoorden HM, Ryan A, Butler LM, Mariadason JM, Giang Phan T, Hayes VM, Sandhu S, Swarbrick A, Corcoran NM, Hertzog PJ, Croucher PI, Hovens C, Parker BS. Owen KL, et al. Among authors: swarbrick a. EMBO Rep. 2020 Jun 4;21(6):e50162. doi: 10.15252/embr.202050162. Epub 2020 Apr 21. EMBO Rep. 2020. PMID: 32314873 Free PMC article.
Restoration of tumor-intrinsic IFN signaling by HDAC inhibition increased tumor cell visibility, promoted long-term antitumor immunity, and blocked cancer growth in bone. Key findings were validated in patients, including loss of tumor-intrinsic IFN signaling and immunogen …
Restoration of tumor-intrinsic IFN signaling by HDAC inhibition increased tumor cell visibility, promoted long-term antitumor immunit …
Tumor inherent interferon regulators as biomarkers of long-term chemotherapeutic response in TNBC.
Brockwell NK, Rautela J, Owen KL, Gearing LJ, Deb S, Harvey K, Spurling A, Zanker D, Chan CL, Cumming HE, Deng N, Zakhour JM, Duivenvoorden HM, Robinson T, Harris M, White M, Fox J, Ooi C, Kumar B, Thomson J, Potasz N, Swarbrick A, Hertzog PJ, Molloy TJ, Toole SO, Ganju V, Parker BS. Brockwell NK, et al. Among authors: swarbrick a. NPJ Precis Oncol. 2019 Aug 29;3:21. doi: 10.1038/s41698-019-0093-2. eCollection 2019. NPJ Precis Oncol. 2019. PMID: 31482136 Free PMC article.
Patients diagnosed with triple negative breast cancer (TNBC) have an increased risk of rapid metastasis compared to other subtypes. Predicting long-term survival post-chemotherapy in patients with TNBC is difficult, yet enhanced infiltration of tumor infiltrating lymphocyt …
Patients diagnosed with triple negative breast cancer (TNBC) have an increased risk of rapid metastasis compared to other subtypes. Predicti …
Non-canonical AR activity facilitates endocrine resistance in breast cancer.
Chia K, Milioli H, Portman N, Laven-Law G, Coulson R, Yong A, Segara D, Parker A, Caldon CE, Deng N, Swarbrick A, Tilley WD, Hickey TE, Lim E. Chia K, et al. Among authors: swarbrick a. Endocr Relat Cancer. 2019 Feb 1;26(2):251-264. doi: 10.1530/ERC-18-0333. Endocr Relat Cancer. 2019. PMID: 30557851
AR antagonism in MCF7-derived tamoxifen-resistant (TamR) and long-term estrogen-deprived breast cancer cell lines were achieved using siRNA-mediated knockdown or pharmacological inhibition with enzalutamide. ...
AR antagonism in MCF7-derived tamoxifen-resistant (TamR) and long-term estrogen-deprived breast cancer cell lines were achieved using …
Cyclin D1 overexpression induces progestin resistance in T-47D breast cancer cells despite p27(Kip1) association with cyclin E-Cdk2.
Musgrove EA, Hunter LJ, Lee CS, Swarbrick A, Hui R, Sutherland RL. Musgrove EA, et al. Among authors: swarbrick a. J Biol Chem. 2001 Dec 14;276(50):47675-83. doi: 10.1074/jbc.M106371200. Epub 2001 Oct 4. J Biol Chem. 2001. PMID: 11590147 Free article.
Long-term growth inhibition, arrest in G(1) phase and reduced activity of both cyclin D1-Cdk4 and cyclin E-Cdk2 are elicited by progestin treatment of breast cancer cells in culture. ...
Long-term growth inhibition, arrest in G(1) phase and reduced activity of both cyclin D1-Cdk4 and cyclin E-Cdk2 are elicited by proge …
Cooperation of p27(Kip1) and p18(INK4c) in progestin-mediated cell cycle arrest in T-47D breast cancer cells.
Swarbrick A, Lee CS, Sutherland RL, Musgrove EA. Swarbrick A, et al. Mol Cell Biol. 2000 Apr;20(7):2581-91. doi: 10.1128/MCB.20.7.2581-2591.2000. Mol Cell Biol. 2000. PMID: 10713180 Free PMC article.
The steroid hormone progesterone regulates proliferation and differentiation in the mammary gland and uterus by cell cycle phase-specific actions. The long-term effect of progestins on T-47D breast cancer cells is inhibition of cellular proliferation. ...
The steroid hormone progesterone regulates proliferation and differentiation in the mammary gland and uterus by cell cycle phase-specific ac …
Mechanisms of cyclin-dependent kinase inactivation by progestins.
Musgrove EA, Swarbrick A, Lee CS, Cornish AL, Sutherland RL. Musgrove EA, et al. Among authors: swarbrick a. Mol Cell Biol. 1998 Apr;18(4):1812-25. doi: 10.1128/MCB.18.4.1812. Mol Cell Biol. 1998. PMID: 9528753 Free PMC article.
In breast cancer cells the predominant effect of synthetic progestins is long-term growth inhibition and arrest in G1 phase. Progestin-mediated growth arrest of T-47D breast cancer cells was preceded by inhibition of cyclin D1-Cdk4, cyclin D3-Cdk4, and cyclin E-Cdk2 kinase …
In breast cancer cells the predominant effect of synthetic progestins is long-term growth inhibition and arrest in G1 phase. Progesti …
Respiratory status and allergy after bronchiolitis.
Murray M, Webb MS, O'Callaghan C, Swarbrick AS, Milner AD. Murray M, et al. Among authors: swarbrick as. Arch Dis Child. 1992 Apr;67(4):482-7. doi: 10.1136/adc.67.4.482. Arch Dis Child. 1992. PMID: 1580676 Free PMC article.
As part of a long term prospective study, 73 children who had been admitted to hospital with viral bronchiolitis as infants, were reviewed 5.5 years later and compared with a carefully matched control group. ...
As part of a long term prospective study, 73 children who had been admitted to hospital with viral bronchiolitis as infants, were rev …