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The Role of Furin in the Pathogenesis of COVID-19-Associated Neurological Disorders.
Ayyubova G, Gychka SG, Nikolaienko SI, Alghenaim FA, Teramoto T, Shults NV, Suzuki YJ. Ayyubova G, et al. Among authors: suzuki yj. Life (Basel). 2024 Feb 19;14(2):279. doi: 10.3390/life14020279. Life (Basel). 2024. PMID: 38398788 Free PMC article.
Neurological disorders have been reported in a large number of coronavirus disease 2019 (COVID-19) patients, suggesting that this disease may have long-term adverse neurological consequences. COVID-19 occurs from infection by a positive-sense single-stranded RNA virus call …
Neurological disorders have been reported in a large number of coronavirus disease 2019 (COVID-19) patients, suggesting that this disease ma …
Placental vascular remodeling in pregnant women with COVID-19.
Gychka SG, Brelidze TI, Kuchyn IL, Savchuk TV, Nikolaienko SI, Zhezhera VM, Chermak II, Suzuki YJ. Gychka SG, et al. Among authors: suzuki yj. PLoS One. 2022 Jul 29;17(7):e0268591. doi: 10.1371/journal.pone.0268591. eCollection 2022. PLoS One. 2022. PMID: 35905056 Free PMC article.
The present study reports that the placental arteries of women who gave birth to live full-term newborns while developing COVID-19 during pregnancy exhibit severe vascular wall thickening and the occlusion of the vascular lumen. ...
The present study reports that the placental arteries of women who gave birth to live full-term newborns while developing COVI …
Protein Expression of Angiotensin-Converting Enzyme 2 (ACE2) is Upregulated in Brains with Alzheimer's Disease.
Ding Q, Shults NV, Gychka SG, Harris BT, Suzuki YJ. Ding Q, et al. Among authors: suzuki yj. Int J Mol Sci. 2021 Feb 8;22(4):1687. doi: 10.3390/ijms22041687. Int J Mol Sci. 2021. PMID: 33567524 Free PMC article.
These results suggest the importance of carefully monitoring patients with both Alzheimer's disease and COVID-19 in order to identify higher viral loads in the brain and long-term adverse neurological consequences....
These results suggest the importance of carefully monitoring patients with both Alzheimer's disease and COVID-19 in order to identify higher …
Viral Infection and Cardiovascular Disease: Implications for the Molecular Basis of COVID-19 Pathogenesis.
Seeherman S, Suzuki YJ. Seeherman S, et al. Among authors: suzuki yj. Int J Mol Sci. 2021 Feb 7;22(4):1659. doi: 10.3390/ijms22041659. Int J Mol Sci. 2021. PMID: 33562193 Free PMC article. Review.
The goal is to provide mechanistic information from the biology of other viral infections in relation to cardiovascular pathologies for the purpose of developing improved vaccines and therapeutic agents effective in preventing and/or treating the acute and long-term conseq …
The goal is to provide mechanistic information from the biology of other viral infections in relation to cardiovascular pathologies for the …
COVID-19 patients may become predisposed to pulmonary arterial hypertension.
Suzuki YJ, Nikolaienko SI, Shults NV, Gychka SG. Suzuki YJ, et al. Med Hypotheses. 2021 Feb;147:110483. doi: 10.1016/j.mehy.2021.110483. Epub 2021 Jan 6. Med Hypotheses. 2021. PMID: 33444904 Free PMC article.
Given the large number of people recovered from either the mild SARS-CoV-2 infection or more severe COVID-19 conditions, it is critical to understand the long-term consequences of the infection by this virus. Our histological evaluations revealed that patients died of COVI …
Given the large number of people recovered from either the mild SARS-CoV-2 infection or more severe COVID-19 conditions, it is critical to u …
SARS-CoV-2 Spike Protein Elicits Cell Signaling in Human Host Cells: Implications for Possible Consequences of COVID-19 Vaccines.
Suzuki YJ, Gychka SG. Suzuki YJ, et al. Vaccines (Basel). 2021 Jan 11;9(1):36. doi: 10.3390/vaccines9010036. Vaccines (Basel). 2021. PMID: 33440640 Free PMC article. Review.
Thus, it is important to be aware that the spike protein produced by the new COVID-19 vaccines may also affect the host cells. We should monitor the long-term consequences of these vaccines carefully, especially when they are administered to otherwise healthy individuals. …
Thus, it is important to be aware that the spike protein produced by the new COVID-19 vaccines may also affect the host cells. We should mon …
Angiotensin-converting enzyme 2 (ACE2) is upregulated in Alzheimer's disease brain.
Ding Q, Shults NV, Harris BT, Suzuki YJ. Ding Q, et al. Among authors: suzuki yj. bioRxiv [Preprint]. 2020 Oct 8:2020.10.08.331157. doi: 10.1101/2020.10.08.331157. bioRxiv. 2020. PMID: 33052346 Free PMC article. Updated. Preprint.
These results warrant monitoring Alzheimer's disease patients with COVID-19 carefully for the possible higher viral load in the brain and long-term adverse neurological consequences....
These results warrant monitoring Alzheimer's disease patients with COVID-19 carefully for the possible higher viral load in the brain and lo …
The role of antioxidants in the era of cardio‑oncology.
Vincent DT, Ibrahim YF, Espey MG, Suzuki YJ. Vincent DT, et al. Among authors: suzuki yj. Cancer Chemother Pharmacol. 2013 Dec;72(6):1157-68. doi: 10.1007/s00280-013-2260-4. Cancer Chemother Pharmacol. 2013. PMID: 23959462 Free PMC article. Review.
While anthracyclines are by far the most well-studied antitumor agents with cardiotoxic properties, evidence now shows that reactive oxygen species may play roles in cardiotoxicity induced by other chemotherapeutic agents such as cyclophosphamide, cisplatin, 5-fluorouracil, and t …
While anthracyclines are by far the most well-studied antitumor agents with cardiotoxic properties, evidence now shows that reactive oxygen …