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Heat-Induced Secretion of Heat Shock Proteins 70 and 90 Does not Affect the Expression of the Glucocorticoid Receptor in Primary Airway Cells in COPD.
Zhou L, Fang L, Roth M, Papakonstantinou E, Tamm M, Stolz D. Zhou L, et al. Among authors: stolz d. Lung. 2024 Apr 19. doi: 10.1007/s00408-024-00680-8. Online ahead of print. Lung. 2024. PMID: 38641747
PURPOSE: The response to glucocorticoids is hampered in many COPD patients by a yet unknown mechanism. Earlier we reported that short-term heat exposure of primary human bronchial epithelial cells (BEC) and airway smooth muscle cells (ASMC) of asthma patients increased the …
PURPOSE: The response to glucocorticoids is hampered in many COPD patients by a yet unknown mechanism. Earlier we reported that short-ter …
Mitochondria-containing extracellular vesicles from mouse vs . human brain endothelial cells for ischemic stroke therapy.
Dave KM, Venna VR, Rao KS, Stolz DB, Quaicoe VA, Maniskas ME, Hildebrand EE, Green D, Chen M, Milosevic J, Zheng SY, Shiva SS, McCullough LD, Manickam DS. Dave KM, et al. Among authors: stolz db. bioRxiv [Preprint]. 2024 Jan 16:2024.01.16.575903. doi: 10.1101/2024.01.16.575903. bioRxiv. 2024. PMID: 38293207 Free PMC article. Preprint.
Ischemic stroke-induced mitochondrial dysfunction in the blood-brain barrier-forming brain endothelial cells ( BECs ) results in long-term neurological dysfunction post-stroke. We previously reported that intravenous administration of human BEC ( hBEC )-derived mitochondri …
Ischemic stroke-induced mitochondrial dysfunction in the blood-brain barrier-forming brain endothelial cells ( BECs ) results in long-ter …
Delivery of mitochondria-containing extracellular vesicles to the BBB for ischemic stroke therapy.
Dave KM, Stolz DB, Manickam DS. Dave KM, et al. Among authors: stolz db. Expert Opin Drug Deliv. 2023 Jul-Dec;20(12):1769-1788. doi: 10.1080/17425247.2023.2279115. Epub 2023 Dec 29. Expert Opin Drug Deliv. 2023. PMID: 37921194 Review.
INTRODUCTION: Ischemic stroke-induced mitochondrial dysfunction in brain endothelial cells (BECs) leads to breakdown of the blood-brain barrier (BBB) causing long-term neurological dysfunction. Restoration of mitochondrial function in injured BECs is a promising therapeuti …
INTRODUCTION: Ischemic stroke-induced mitochondrial dysfunction in brain endothelial cells (BECs) leads to breakdown of the blood-brain barr …
COPD and multimorbidity: recognising and addressing a syndemic occurrence.
Fabbri LM, Celli BR, Agustí A, Criner GJ, Dransfield MT, Divo M, Krishnan JK, Lahousse L, Montes de Oca M, Salvi SS, Stolz D, Vanfleteren LEGW, Vogelmeier CF. Fabbri LM, et al. Among authors: stolz d. Lancet Respir Med. 2023 Nov;11(11):1020-1034. doi: 10.1016/S2213-2600(23)00261-8. Epub 2023 Sep 8. Lancet Respir Med. 2023. PMID: 37696283 Review.
As many chronic diseases have shared risk factors (eg, ageing, smoking, pollution, inactivity, and poverty), we argue that a shift from the current paradigm in which COPD is considered as a single disease with comorbidities, to one in which COPD is considered as part of a multimo …
As many chronic diseases have shared risk factors (eg, ageing, smoking, pollution, inactivity, and poverty), we argue that a shift from the …
Mitochondria-containing extracellular vesicles (EV) reduce mouse brain infarct sizes and EV/HSP27 protect ischemic brain endothelial cultures.
Dave KM, Stolz DB, Venna VR, Quaicoe VA, Maniskas ME, Reynolds MJ, Babidhan R, Dobbins DX, Farinelli MN, Sullivan A, Bhatia TN, Yankello H, Reddy R, Bae Y, Leak RK, Shiva SS, McCullough LD, Manickam DS. Dave KM, et al. Among authors: stolz db. J Control Release. 2023 Feb;354:368-393. doi: 10.1016/j.jconrel.2023.01.025. Epub 2023 Jan 18. J Control Release. 2023. PMID: 36642252 Free PMC article.
This one-two punch approach to increase BEC metabolic function and tight junction integrity may be a promising strategy for BBB protection and prevention of long-term neurological dysfunction post-ischemic stroke....
This one-two punch approach to increase BEC metabolic function and tight junction integrity may be a promising strategy for BBB protection a …
Unmet needs in pneumonia research: a comprehensive approach by the CAPNETZ study group.
Pletz MW, Jensen AV, Bahrs C, Davenport C, Rupp J, Witzenrath M, Barten-Neiner G, Kolditz M, Dettmer S, Chalmers JD, Stolz D, Suttorp N, Aliberti S, Kuebler WM, Rohde G. Pletz MW, et al. Among authors: stolz d. Respir Res. 2022 Sep 10;23(1):239. doi: 10.1186/s12931-022-02117-3. Respir Res. 2022. PMID: 36088316 Free PMC article. Review.
RESULTS: Eleven topics for future CAP research were identified: detection of causative pathogens, next generation sequencing for antimicrobial treatment guidance, imaging diagnostics, biomarkers, risk stratification, antiviral and antibiotic treatment, adjunctive therapy, vaccine …
RESULTS: Eleven topics for future CAP research were identified: detection of causative pathogens, next generation sequencing for antimicrobi …
Causal Effects of Body Mass Index on Airflow Obstruction and Forced Mid-Expiratory Flow: A Mendelian Randomization Study Taking Interactions and Age-Specific Instruments Into Consideration Toward a Life Course Perspective.
Probst-Hensch N, Jeong A, Stolz D, Pons M, Soccal PM, Bettschart R, Jarvis D, Holloway JW, Kronenberg F, Imboden M, Schindler C, Lovison GF. Probst-Hensch N, et al. Among authors: stolz d. Front Public Health. 2021 May 11;9:584955. doi: 10.3389/fpubh.2021.584955. eCollection 2021. Front Public Health. 2021. PMID: 34046380 Free PMC article.
The causal effects of BMI in childhood and adulthood on FEV1/FVC and FEF25-75% were assessed in predictive (BMI averaged over 1st and 2nd, lung function (LF) averaged over 2nd and 3rd follow-up; N = 2,850) and long-term cross-sectional models (BMI and LF averaged over all …
The causal effects of BMI in childhood and adulthood on FEV1/FVC and FEF25-75% were assessed in predictive (BMI averaged over 1st and 2nd, l …
Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke.
Shi L, Sun Z, Su W, Xu F, Xie D, Zhang Q, Dai X, Iyer K, Hitchens TK, Foley LM, Li S, Stolz DB, Chen K, Ding Y, Thomson AW, Leak RK, Chen J, Hu X. Shi L, et al. Among authors: stolz db. Immunity. 2021 Jul 13;54(7):1527-1542.e8. doi: 10.1016/j.immuni.2021.04.022. Epub 2021 May 19. Immunity. 2021. PMID: 34015256 Free PMC article.
The precise mechanisms underlying the beneficial effects of regulatory T (Treg) cells on long-term tissue repair remain elusive. Here, using single-cell RNA sequencing and flow cytometry, we found that Treg cells infiltrated the brain 1 to 5 weeks after experimental stroke …
The precise mechanisms underlying the beneficial effects of regulatory T (Treg) cells on long-term tissue repair remain elusive. Here …
Copeptin, pro-atrial natriuretic peptide and pro-adrenomedullin as markers of hypoxic stress in patients with obstructive sleep apnea-a prospective intervention study.
Karakioulaki M, Grendelmeier P, Strobel W, Schmid T, Jahn K, Grize L, Tamm M, Stolz D. Karakioulaki M, et al. Among authors: stolz d. Respir Res. 2021 Apr 20;22(1):114. doi: 10.1186/s12931-021-01704-0. Respir Res. 2021. PMID: 33879148 Free PMC article.
ProANP levels might serve as a potential proxy for the acute response to non-invasive ventilation (12 h), while proADM reflects the long-term response (1 and 6 months)....
ProANP levels might serve as a potential proxy for the acute response to non-invasive ventilation (12 h), while proADM reflects the long- …
Immunomodulatory drugs downregulate IKZF1 leading to expansion of hematopoietic progenitors with concomitant block of megakaryocytic maturation.
Liu A, Li S, Donnenberg V, Fu J, Gollin SM, Ma H, Lu C, Stolz DB, Mapara MY, Monaghan SA, Lentzsch S. Liu A, et al. Among authors: stolz db. Haematologica. 2018 Oct;103(10):1688-1697. doi: 10.3324/haematol.2018.188227. Epub 2018 Jun 28. Haematologica. 2018. PMID: 29954930 Free PMC article.
Our data not only provide the mechanism for the immunomodulatory drugs induced thrombocytopenia but also help to explain the higher risk of secondary malignancies and long-term cytopenia induced by enhanced cell cycling and subsequent exhaustion of the stem cell pool....
Our data not only provide the mechanism for the immunomodulatory drugs induced thrombocytopenia but also help to explain the higher risk of …
56 results