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Sustained Coinfections with Staphylococcus aureus and Pseudomonas aeruginosa in Cystic Fibrosis.
Am J Respir Crit Care Med. 2021 Feb 1;203(3):328-338. doi: 10.1164/rccm.202004-1322OC.
Am J Respir Crit Care Med. 2021.
PMID: 32750253
Free PMC article.
Contrary to common assumption, we found no pattern of replacement of S. aureus by P. aeruginosa. Many patients with CF have durable long-term coinfection with these organisms. New strategies are needed to prevent and treat these infections....
Contrary to common assumption, we found no pattern of replacement of S. aureus by P. aeruginosa. Many patients with CF have durable long- …
A Novel AAV-mediated Gene Delivery System Corrects CFTR Function in Pigs.
Cooney AL, Thornell IM, Singh BK, Shah VS, Stoltz DA, McCray PB Jr, Zabner J, Sinn PL.
Cooney AL, et al. Among authors: stoltz da.
Am J Respir Cell Mol Biol. 2019 Dec;61(6):747-754. doi: 10.1165/rcmb.2019-0006OC.
Am J Respir Cell Mol Biol. 2019.
PMID: 31184507
Free PMC article.
Because of the packaging constraints of AAV, careful consideration was required to ensure that the vector would package and express its CFTR cDNA cargo. In this short-term study, PB/AAV-CFTR was aerosolized to the airways of CF pigs in the absence of the transposase. ...
Because of the packaging constraints of AAV, careful consideration was required to ensure that the vector would package and express its CFTR …
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Widespread airway distribution and short-term phenotypic correction of cystic fibrosis pigs following aerosol delivery of piggyBac/adenovirus.
Cooney AL, Singh BK, Loza LM, Thornell IM, Hippee CE, Powers LS, Ostedgaard LS, Meyerholz DK, Wohlford-Lenane C, Stoltz DA, B McCray P Jr, Sinn PL.
Cooney AL, et al. Among authors: stoltz da.
Nucleic Acids Res. 2018 Oct 12;46(18):9591-9600. doi: 10.1093/nar/gky773.
Nucleic Acids Res. 2018.
PMID: 30165523
Free PMC article.
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Inhaled hypertonic saline in adults hospitalised for exacerbation of cystic fibrosis lung disease: a retrospective study.
Pezzulo AA, Stoltz DA, Hornick DB, Durairaj L.
Pezzulo AA, et al. Among authors: stoltz da.
BMJ Open. 2012 Apr 19;2(2):e000407. doi: 10.1136/bmjopen-2011-000407. Print 2012.
BMJ Open. 2012.
PMID: 22517980
Free PMC article.
BACKGROUND: Inhaled hypertonic saline (HTS) improves quality of life and reduces pulmonary exacerbations when given long term in patients with cystic fibrosis (CF). While increasingly being offered for acute pulmonary exacerbations, little is known about the efficacy in th …
BACKGROUND: Inhaled hypertonic saline (HTS) improves quality of life and reduces pulmonary exacerbations when given long term in pati …
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Cystic fibrosis transmembrane conductance regulator intracellular processing, trafficking, and opportunities for mutation-specific treatment.
Rogan MP, Stoltz DA, Hornick DB.
Rogan MP, et al. Among authors: stoltz da.
Chest. 2011 Jun;139(6):1480-1490. doi: 10.1378/chest.10-2077.
Chest. 2011.
PMID: 21652558
Review.
We review the results of encouraging clinical trials examining orally administered therapeutics, including agents that promote read-through of class I mutations (premature termination codons); correctors, which overcome the CFTR misfolding that characterizes the common class II m …
We review the results of encouraging clinical trials examining orally administered therapeutics, including agents that promote read-through …
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