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Differential effects of protein kinase C on the levels of epithelial Na+ channel subunit proteins.
Stockand JD, Bao HF, Schenck J, Malik B, Middleton P, Schlanger LE, Eaton DC. Stockand JD, et al. J Biol Chem. 2000 Aug 18;275(33):25760-5. doi: 10.1074/jbc.M003615200. J Biol Chem. 2000. PMID: 10829029 Free article.
These results directly show for the first time that PKC differentially regulates ENaC subunit levels by decreasing the levels of beta and gamma but not alphaENaC protein. These results imply a PKC-dependent, long term decrease in Na(+) reabsorption....
These results directly show for the first time that PKC differentially regulates ENaC subunit levels by decreasing the levels of beta and ga …